V1R42_MOUSE
ID V1R42_MOUSE Reviewed; 329 AA.
AC Q8VBS7; Q9EQ49;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Vomeronasal type-1 receptor 42;
DE AltName: Full=Vomeronasal type-1 receptor A1;
DE AltName: Full=Vomeronasal type-1 receptor A10;
DE AltName: Full=Vomeronasal type-1 receptor A3;
DE AltName: Full=Vomeronasal type-1 receptor A6;
GN Name=Vmn1r42;
GN Synonyms=V1ra1 {ECO:0000312|EMBL:BAB79209.1}, V1ra10,
GN V1ra3 {ECO:0000312|EMBL:BAB79210.1}, V1ra6;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAB79210.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Sam M., Matsunami H., Buck L.;
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000312|EMBL:BAB79210.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=C57BL/6J;
RA Rodriguez I., Mombaerts P.;
RL Submitted (JUL-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|EMBL:AAG42079.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-329.
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42079.1};
RX PubMed=11116090; DOI=10.1101/gr.10.12.1958;
RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.;
RT "Sequence diversity and genomic organization of vomeronasal receptor genes
RT in the mouse.";
RL Genome Res. 10:1958-1967(2000).
RN [4] {ECO:0000305}
RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12214233; DOI=10.1038/nature00955;
RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA Ogawa S., Zufall F., Mombaerts P.;
RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT receptor genes.";
RL Nature 419:70-74(2002).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social and reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12%
CC of the V1r repertoire) show a lack of chemosensory response to a subset
CC of known pheromonal ligands and changes in maternal aggression as well
CC as male reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB062891; BAB79209.1; -; Genomic_DNA.
DR EMBL; AB062892; BAB79210.1; -; Genomic_DNA.
DR EMBL; AY044662; AAK98772.1; -; Genomic_DNA.
DR EMBL; AF291485; AAG42079.1; -; Genomic_DNA.
DR CCDS; CCDS57439.1; -.
DR RefSeq; NP_444451.2; NM_053221.2.
DR AlphaFoldDB; Q8VBS7; -.
DR SMR; Q8VBS7; -.
DR BioGRID; 227516; 1.
DR STRING; 10090.ENSMUSP00000086840; -.
DR GlyGen; Q8VBS7; 1 site.
DR PaxDb; Q8VBS7; -.
DR PRIDE; Q8VBS7; -.
DR DNASU; 113848; -.
DR Ensembl; ENSMUST00000089419; ENSMUSP00000086840; ENSMUSG00000068232.
DR Ensembl; ENSMUST00000226436; ENSMUSP00000154788; ENSMUSG00000068232.
DR Ensembl; ENSMUST00000227279; ENSMUSP00000154442; ENSMUSG00000068232.
DR GeneID; 113848; -.
DR KEGG; mmu:113848; -.
DR UCSC; uc009cwm.2; mouse.
DR CTD; 113848; -.
DR MGI; MGI:2148511; Vmn1r42.
DR VEuPathDB; HostDB:ENSMUSG00000068232; -.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR GeneTree; ENSGT01030000234553; -.
DR HOGENOM; CLU_058641_0_0_1; -.
DR InParanoid; Q8VBS7; -.
DR OMA; IMVIANG; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q8VBS7; -.
DR BioGRID-ORCS; 113848; 3 hits in 68 CRISPR screens.
DR PRO; PR:Q8VBS7; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8VBS7; protein.
DR Bgee; ENSMUSG00000068232; Expressed in lumbar subsegment of spinal cord and 3 other tissues.
DR ExpressionAtlas; Q8VBS7; baseline and differential.
DR Genevisible; Q8VBS7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..329
FT /note="Vomeronasal type-1 receptor 42"
FT /id="PRO_0000239961"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..65
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..209
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..254
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 276..285
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 307..329
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 101..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 329 AA; 37352 MW; FF172A215088CC79 CRC64;
MGDILFSSPQ SMFSHTMNKN SILHTHSIIG KTFFSEIGIG ISGNSFLLLV HILKFIRGHR
PRLTDLPIGL LSLIHLLMLL VAAFIATDIF ISRRGWDDII CKFLVYLYRV LRGFSLCTTS
MLSILQAIIL SPRSSCLAKF KHISPHHISG AILFLSVLYM LIGSQLLVSI IATPNLTMND
FIYVTQSCSI LPLSYLMQSI YSTLLAIREF FLISLMVLSN WYMVALLSMH RKQTQHLHGT
NLSPKKSPEQ SATQTILMLI SFFLLMTIYD TIVSCSRTMF LNDPTSYSIE LFIMHIYATV
SPFVFMSTEK HIVNFLRSLG KRVINFNLH
