V1R43_MOUSE
ID V1R43_MOUSE Reviewed; 329 AA.
AC Q8VIC9; Q05A91; Q9EQ50;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Vomeronasal type-1 receptor 43;
DE AltName: Full=Vomeronasal type-1 receptor A2;
DE AltName: Full=Vomeronasal type-1 receptor A5;
GN Name=Vmn1r43; Synonyms=V1ra2 {ECO:0000312|EMBL:BAB79211.1}, V1ra5;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:BAB79211.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Sam M., Matsunami H., Buck L.;
RT "Vomeronasal receptor gene diversity in the mammalian genome.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [3] {ECO:0000312|EMBL:AAG42078.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-329.
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42078.1};
RX PubMed=11116090; DOI=10.1101/gr.10.12.1958;
RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.;
RT "Sequence diversity and genomic organization of vomeronasal receptor genes
RT in the mouse.";
RL Genome Res. 10:1958-1967(2000).
RN [4] {ECO:0000305}
RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12214233; DOI=10.1038/nature00955;
RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA Ogawa S., Zufall F., Mombaerts P.;
RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT receptor genes.";
RL Nature 419:70-74(2002).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social and reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12%
CC of the V1r repertoire) show a lack of chemosensory response to a subset
CC of known pheromonal ligands and changes in maternal aggression as well
CC as male reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AB062893; BAB79211.1; -; Genomic_DNA.
DR EMBL; BC125364; AAI25365.1; -; mRNA.
DR EMBL; AF291484; AAG42078.1; -; Genomic_DNA.
DR CCDS; CCDS57440.1; -.
DR RefSeq; NP_444450.2; NM_053220.2.
DR AlphaFoldDB; Q8VIC9; -.
DR SMR; Q8VIC9; -.
DR STRING; 10090.ENSMUSP00000086839; -.
DR GlyGen; Q8VIC9; 2 sites.
DR PaxDb; Q8VIC9; -.
DR PRIDE; Q8VIC9; -.
DR ProteomicsDB; 300102; -.
DR DNASU; 113847; -.
DR Ensembl; ENSMUST00000089418; ENSMUSP00000086839; ENSMUSG00000068231.
DR Ensembl; ENSMUST00000226741; ENSMUSP00000154439; ENSMUSG00000068231.
DR Ensembl; ENSMUST00000226983; ENSMUSP00000153713; ENSMUSG00000068231.
DR Ensembl; ENSMUST00000228709; ENSMUSP00000154510; ENSMUSG00000068231.
DR GeneID; 113847; -.
DR KEGG; mmu:113847; -.
DR UCSC; uc009cwn.2; mouse.
DR CTD; 113847; -.
DR MGI; MGI:2148510; Vmn1r43.
DR VEuPathDB; HostDB:ENSMUSG00000068231; -.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR GeneTree; ENSGT01030000234553; -.
DR HOGENOM; CLU_058641_4_0_1; -.
DR InParanoid; Q8VIC9; -.
DR OMA; MSFIATE; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q8VIC9; -.
DR BioGRID-ORCS; 113847; 2 hits in 47 CRISPR screens.
DR PRO; PR:Q8VIC9; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8VIC9; protein.
DR Bgee; ENSMUSG00000068231; Expressed in ectoplacental cone and 12 other tissues.
DR Genevisible; Q8VIC9; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..329
FT /note="Vomeronasal type-1 receptor 43"
FT /id="PRO_0000239960"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..65
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..147
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 148..168
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 169..209
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 210..230
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 231..255
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 256..276
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 277..285
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 307..329
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 201
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 101..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 329 AA; 37649 MW; 2A3AE9F4160994C4 CRC64;
MSKILFFSPC SLFSHTMNKN SRLHTNSNIG NTFFSEIGIG ITGNSFLLLY HILKFIRGHR
PRLTDLPIGL LSLIHLLMLL VAAFIATDIF ISRRGWDDII CKFLVYLYRV LRGLSLCTTS
MLSVLQAIIL SPRSSCLSKF KHISLHHILC AILFLSVLYM LISSQLLVSI IATPNLTTND
LTYVTQSCSI LPLSYLVESI NSTLLAIREY FLISLMFLST WYIVALLCMH RKQTQHLQET
RLSLKKSPEQ SATQTILMLM TFFVLMTIYD NIVSCLRTML LNDPTSYSIE LFMIHIYATV
SPFVFMSNEK HIVNFLRSMG KRMINLNLH
