V1R44_MOUSE
ID V1R44_MOUSE Reviewed; 310 AA.
AC Q9EQ47; B9EKS6; Q3B815; Q3B816; Q8R2E5; Q8VIC5;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 27-JUL-2011, sequence version 3.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Vomeronasal type-1 receptor 44;
DE AltName: Full=Vomeronasal type-1 receptor A10;
DE AltName: Full=Vomeronasal type-1 receptor B11;
DE AltName: Full=Vomeronasal type-1 receptor B4;
GN Name=Vmn1r44;
GN Synonyms=V1ra10 {ECO:0000312|EMBL:BAB79216.1},
GN V1rb11 {ECO:0000312|EMBL:AAL47870.1}, V1rb4;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAG42086.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42086.1};
RX PubMed=11116090; DOI=10.1101/gr.10.12.1958;
RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.;
RT "Sequence diversity and genomic organization of vomeronasal receptor genes
RT in the mouse.";
RL Genome Res. 10:1958-1967(2000).
RN [2] {ECO:0000312|EMBL:BAB79216.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Sam M., Matsunami H., Buck L.;
RT "Vomeronasal receptor gene diversity in the mammalian genome.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|EMBL:BAB79216.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAI07186.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5] {ECO:0000312|EMBL:AAL47870.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 1-296.
RX PubMed=11802169; DOI=10.1038/nn795;
RA Rodriguez I., Del Punta K., Rothman A., Ishii T., Mombaerts P.;
RT "Multiple new and isolated families within the mouse superfamily of V1r
RT vomeronasal receptors.";
RL Nat. Neurosci. 5:134-140(2002).
RN [6] {ECO:0000305}
RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12214233; DOI=10.1038/nature00955;
RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA Ogawa S., Zufall F., Mombaerts P.;
RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT receptor genes.";
RL Nature 419:70-74(2002).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social and reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12%
CC of the V1r repertoire) show a lack of chemosensory response to a subset
CC of known pheromonal ligands and changes in maternal aggression as well
CC as male reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAL47870.1; Type=Frameshift; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; AF291492; AAG42086.1; -; Genomic_DNA.
DR EMBL; AB062899; BAB79216.1; -; Genomic_DNA.
DR EMBL; CH466523; EDK99272.1; -; Genomic_DNA.
DR EMBL; BC107184; AAI07185.1; -; mRNA.
DR EMBL; BC107185; AAI07186.1; -; mRNA.
DR EMBL; BC151088; AAI51089.1; -; mRNA.
DR EMBL; AY065465; AAL47870.1; ALT_FRAME; Genomic_DNA.
DR CCDS; CCDS39558.1; -.
DR RefSeq; NP_444457.2; NM_053227.2.
DR AlphaFoldDB; Q9EQ47; -.
DR SMR; Q9EQ47; -.
DR STRING; 10090.ENSMUSP00000100706; -.
DR GlyGen; Q9EQ47; 1 site.
DR iPTMnet; Q9EQ47; -.
DR PhosphoSitePlus; Q9EQ47; -.
DR PaxDb; Q9EQ47; -.
DR PRIDE; Q9EQ47; -.
DR DNASU; 113854; -.
DR Ensembl; ENSMUST00000089420; ENSMUSP00000100706; ENSMUSG00000068234.
DR Ensembl; ENSMUST00000204656; ENSMUSP00000145135; ENSMUSG00000068234.
DR Ensembl; ENSMUST00000226345; ENSMUSP00000154318; ENSMUSG00000068234.
DR Ensembl; ENSMUST00000226760; ENSMUSP00000154174; ENSMUSG00000068234.
DR Ensembl; ENSMUST00000227047; ENSMUSP00000153999; ENSMUSG00000068234.
DR Ensembl; ENSMUST00000227456; ENSMUSP00000153772; ENSMUSG00000068234.
DR Ensembl; ENSMUST00000228700; ENSMUSP00000154809; ENSMUSG00000068234.
DR GeneID; 113854; -.
DR KEGG; mmu:113854; -.
DR UCSC; uc009cwo.1; mouse.
DR CTD; 113854; -.
DR MGI; MGI:2148517; Vmn1r44.
DR VEuPathDB; HostDB:ENSMUSG00000068234; -.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR GeneTree; ENSGT01030000234553; -.
DR HOGENOM; CLU_058641_0_0_1; -.
DR InParanoid; Q9EQ47; -.
DR OMA; ICTEKHM; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q9EQ47; -.
DR BioGRID-ORCS; 113854; 2 hits in 48 CRISPR screens.
DR PRO; PR:Q9EQ47; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9EQ47; protein.
DR Bgee; ENSMUSG00000068234; Expressed in spermatid.
DR ExpressionAtlas; Q9EQ47; baseline.
DR Genevisible; Q9EQ47; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Vomeronasal type-1 receptor 44"
FT /id="PRO_0000239976"
FT TOPO_DOM 1..20
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..190
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 85..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 3
FT /note="K -> L (in Ref. 1; AAG42086 and 4; AAI07185/
FT AAI07186)"
FT /evidence="ECO:0000305"
FT CONFLICT 11
FT /note="T -> S (in Ref. 1; AAG42086)"
FT /evidence="ECO:0000305"
FT CONFLICT 308
FT /note="A -> V (in Ref. 4; AAI07185)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 310 AA; 35388 MW; E3E98ACEECC766F0 CRC64;
MNKANLLHID TNIKITLLAE VSVGISANSI LFIAYLCMLL GENRHKPIDL YIAFLSLTQL
MLLITMGLIA VDMFMPWGRW DSTTCQSLIY LHRFLRGLTL CATCLLNVLW TITLSSRNSC
LAKFKHKYPH HISGAFLFLC VLYMSFSSHF LVSMTVTPNL TSENFMYVTQ SCSLLPMSYS
RTSMFSTPVA IRETFLISLM ALSSGYMVAL LWRHKKQAQH LRSTSLSSKA SPEQRATRTI
LLLMSFFVVF YILDTVIFHS RMKFKDGSIL YCFQIIVSHS YVTVSPFVFI CTEKHIIKFL
RSMCGRIANI
