V1R45_MOUSE
ID V1R45_MOUSE Reviewed; 318 AA.
AC Q8VIC7; Q9Z196;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 114.
DE RecName: Full=Vomeronasal type-1 receptor 45;
DE AltName: Full=Pheromone receptor 2;
DE AltName: Full=Vomeronasal type-1 receptor A2;
DE Short=mV1R2;
DE AltName: Full=Vomeronasal type-1 receptor A9;
GN Name=Vmn1r45;
GN Synonyms=Pr2 {ECO:0000312|EMBL:CAA73256.1}, V1ra2,
GN V1ra9 {ECO:0000312|EMBL:BAB79214.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAA73256.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ {ECO:0000312|EMBL:CAA73256.1};
RC TISSUE=Vomeronasal organ {ECO:0000312|EMBL:CAA73256.1};
RX PubMed=9757043; DOI=10.1016/s0169-328x(98)00183-1;
RA Saito H., Mimmack M.L., Keverne E.B., Kishimoto J., Emson P.C.;
RT "Isolation of mouse vomeronasal receptor genes and their co-localization
RT with specific G-protein messenger RNAs.";
RL Brain Res. Mol. Brain Res. 60:215-227(1998).
RN [2] {ECO:0000312|EMBL:BAB79214.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Sam M., Matsunami H., Buck L.;
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12214233; DOI=10.1038/nature00955;
RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA Ogawa S., Zufall F., Mombaerts P.;
RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT receptor genes.";
RL Nature 419:70-74(2002).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social and reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in a subset of sensory neurons located in
CC the apical layer of the vomeronasal organ.
CC {ECO:0000269|PubMed:9757043}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12%
CC of the V1r repertoire) show a lack of chemosensory response to a subset
CC of known pheromonal ligands and changes in maternal aggression as well
CC as male reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=CAA73256.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; Y12724; CAA73256.1; ALT_INIT; mRNA.
DR EMBL; AB062896; BAB79214.1; -; Genomic_DNA.
DR CCDS; CCDS39559.1; -.
DR RefSeq; NP_035814.2; NM_011684.2.
DR AlphaFoldDB; Q8VIC7; -.
DR SMR; Q8VIC7; -.
DR GlyGen; Q8VIC7; 1 site.
DR PaxDb; Q8VIC7; -.
DR PRIDE; Q8VIC7; -.
DR DNASU; 22297; -.
DR Ensembl; ENSMUST00000054202; ENSMUSP00000052123; ENSMUSG00000044248.
DR Ensembl; ENSMUST00000227426; ENSMUSP00000153735; ENSMUSG00000044248.
DR Ensembl; ENSMUST00000227977; ENSMUSP00000154708; ENSMUSG00000044248.
DR Ensembl; ENSMUST00000228662; ENSMUSP00000154795; ENSMUSG00000044248.
DR GeneID; 22297; -.
DR KEGG; mmu:22297; -.
DR UCSC; uc009cwp.1; mouse.
DR CTD; 22297; -.
DR MGI; MGI:1333762; Vmn1r45.
DR VEuPathDB; HostDB:ENSMUSG00000044248; -.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR GeneTree; ENSGT01030000234553; -.
DR HOGENOM; CLU_058641_0_0_1; -.
DR InParanoid; Q8VIC7; -.
DR OMA; FMSTENH; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q8VIC7; -.
DR BioGRID-ORCS; 22297; 0 hits in 47 CRISPR screens.
DR PRO; PR:Q8VIC7; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q8VIC7; protein.
DR Bgee; ENSMUSG00000044248; Expressed in dentate gyrus of hippocampal formation and 11 other tissues.
DR ExpressionAtlas; Q8VIC7; baseline and differential.
DR Genevisible; Q8VIC7; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..318
FT /note="Vomeronasal type-1 receptor 45"
FT /id="PRO_0000239957"
FT TOPO_DOM 1..32
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 33..53
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 54..65
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..206
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 207..227
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 228..254
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 276..285
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 307..318
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 101..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 111
FT /note="L -> W (in Ref. 1; CAA73256)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 318 AA; 36348 MW; 69BCF93B9A00B2C0 CRC64;
MSEILFFSPQ PLFSHMMNKN SRLHTHSNIK NTFFSEIGIG ILGNSFLLLF HILKFIRGHR
LRLTDLPIGL LSLIHLLMLL LMAFIATDIF ISRRGWDDII CKFLVYLYRV LRGLSLCTTS
MLSVLQAIIL SPRSSCLAKL KHKYPHHISC AIIFLSVLYM LISSHILLSI IATPNLTRND
FLYVTQSCSI LPLSYVMQSM YSTLLALREV FLISLMVLST LYMVVLLCRH RKQAQHLQGT
SLSPKASAEQ RATQTILMLM TFFVLMSIFD SIVSCSRTMF LDDPTSYSIH IFVMHIYATV
SPFVFMSTEK HIVNILRG
