V1R46_MOUSE
ID V1R46_MOUSE Reviewed; 309 AA.
AC Q9EQ45;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 118.
DE RecName: Full=Vomeronasal type-1 receptor 46;
DE AltName: Full=Vomeronasal type-1 receptor A13;
DE AltName: Full=Vomeronasal type-1 receptor B8;
GN Name=Vmn1r46; Synonyms=V1ra13 {ECO:0000312|EMBL:BAB79220.1}, V1rb8;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAG42088.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42088.1};
RX PubMed=11116090; DOI=10.1101/gr.10.12.1958;
RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.;
RT "Sequence diversity and genomic organization of vomeronasal receptor genes
RT in the mouse.";
RL Genome Res. 10:1958-1967(2000).
RN [2] {ECO:0000312|EMBL:BAB79220.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Sam M., Matsunami H., Buck L.;
RT "Vomeronasal receptor gene diversity in the mammalian genome.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12214233; DOI=10.1038/nature00955;
RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA Ogawa S., Zufall F., Mombaerts P.;
RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT receptor genes.";
RL Nature 419:70-74(2002).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social and reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12%
CC of the V1r repertoire) show a lack of chemosensory response to a subset
CC of known pheromonal ligands and changes in maternal aggression as well
CC as male reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF291494; AAG42088.1; -; Genomic_DNA.
DR EMBL; AB062903; BAB79220.1; -; Genomic_DNA.
DR CCDS; CCDS20348.1; -.
DR RefSeq; NP_444459.1; NM_053229.1.
DR RefSeq; XP_006505446.1; XM_006505383.1.
DR AlphaFoldDB; Q9EQ45; -.
DR SMR; Q9EQ45; -.
DR STRING; 10090.ENSMUSP00000075197; -.
DR GlyGen; Q9EQ45; 1 site.
DR PaxDb; Q9EQ45; -.
DR PRIDE; Q9EQ45; -.
DR DNASU; 113856; -.
DR Ensembl; ENSMUST00000075797; ENSMUSP00000075197; ENSMUSG00000061653.
DR Ensembl; ENSMUST00000205088; ENSMUSP00000144888; ENSMUSG00000061653.
DR Ensembl; ENSMUST00000226715; ENSMUSP00000154054; ENSMUSG00000061653.
DR Ensembl; ENSMUST00000228401; ENSMUSP00000154175; ENSMUSG00000061653.
DR GeneID; 113856; -.
DR KEGG; mmu:113856; -.
DR UCSC; uc009cwq.1; mouse.
DR CTD; 113856; -.
DR MGI; MGI:2148519; Vmn1r46.
DR VEuPathDB; HostDB:ENSMUSG00000061653; -.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR GeneTree; ENSGT01030000234553; -.
DR HOGENOM; CLU_058641_0_0_1; -.
DR InParanoid; Q9EQ45; -.
DR OMA; NRITCKC; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q9EQ45; -.
DR BioGRID-ORCS; 113856; 1 hit in 68 CRISPR screens.
DR PRO; PR:Q9EQ45; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9EQ45; protein.
DR Genevisible; Q9EQ45; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Vomeronasal type-1 receptor 46"
FT /id="PRO_0000239980"
FT TOPO_DOM 1..20
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..85
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 86..106
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 107..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..192
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 158
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 85..171
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 309 AA; 35006 MW; 8CE767B89A8754DE CRC64;
MNKANIFCTD TNMKVILFSE VSVGISANSI LFISHLCMFL GESRPKPIDL YIAFFSLTHL
MLLVTMGLIA VDMFMPGGRW DSTTCTFLMY LHIVLRGPTL CATCLLNVLW TITLSPRNSC
LTKFKHKSPH HISGAFLFLC VLYMSLSSEL LSITASLNLT SENFLYVSQS CSILPMSYSI
KSMFSTKMAI REAFLIGLMV LSSGYMVALL WSHKKQAQHL HSNSLSLKAS PEQRATRTIM
LLMSFFVVFY ILDSVIFYSR MKFKDDSIFV CVQIIVSHSY VTVSPFVFIC TEKHIIKFFW
SLCGRIVNI
