V1R47_MOUSE
ID V1R47_MOUSE Reviewed; 310 AA.
AC Q9EQ51; Q2M2P9; Q8VIC8;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 106.
DE RecName: Full=Vomeronasal type-1 receptor 47;
DE AltName: Full=Vomeronasal type-1 receptor A4;
DE AltName: Full=Vomeronasal type-1 receptor A7;
GN Name=Vmn1r47; Synonyms=V1ra4, V1ra7 {ECO:0000312|EMBL:BAB79213.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAG42077.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42077.1};
RX PubMed=11116090; DOI=10.1101/gr.10.12.1958;
RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.;
RT "Sequence diversity and genomic organization of vomeronasal receptor genes
RT in the mouse.";
RL Genome Res. 10:1958-1967(2000).
RN [2] {ECO:0000312|EMBL:BAB79213.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Sam M., Matsunami H., Buck L.;
RT "Vomeronasal receptor gene diversity in the mammalian genome.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|EMBL:AAI11823.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 2-310.
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305}
RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12214233; DOI=10.1038/nature00955;
RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA Ogawa S., Zufall F., Mombaerts P.;
RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT receptor genes.";
RL Nature 419:70-74(2002).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social and reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12%
CC of the V1r repertoire) show a lack of chemosensory response to a subset
CC of known pheromonal ligands and changes in maternal aggression as well
CC as male reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF291483; AAG42077.1; -; Genomic_DNA.
DR EMBL; AB062895; BAB79213.1; -; Genomic_DNA.
DR EMBL; BC111822; AAI11823.1; -; mRNA.
DR CCDS; CCDS20349.1; -.
DR RefSeq; NP_444449.2; NM_053219.2.
DR AlphaFoldDB; Q9EQ51; -.
DR SMR; Q9EQ51; -.
DR IntAct; Q9EQ51; 1.
DR STRING; 10090.ENSMUSP00000074422; -.
DR GlyGen; Q9EQ51; 1 site.
DR PaxDb; Q9EQ51; -.
DR PRIDE; Q9EQ51; -.
DR DNASU; 113846; -.
DR GeneID; 113846; -.
DR KEGG; mmu:113846; -.
DR UCSC; uc009cwr.1; mouse.
DR CTD; 113846; -.
DR MGI; MGI:2148509; Vmn1r47.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR InParanoid; Q9EQ51; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q9EQ51; -.
DR BioGRID-ORCS; 113846; 2 hits in 62 CRISPR screens.
DR PRO; PR:Q9EQ51; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9EQ51; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Vomeronasal type-1 receptor 47"
FT /id="PRO_0000239959"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..91
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 85..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 230..232
FT /note="TAP -> ASA (in Ref. 2; BAB79213)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 310 AA; 35433 MW; 6892908678F269CA CRC64;
MNENSRLHTH SNIRNTFFSE IGIGISGNSF LLLFHIIKFF RGHRPRLTDL PIGLLSLIHL
LMLLVAAVIA TDIFISWRGW NDIICKFLVY LYRSLRGLSL CTTSMLSVLQ AIILSPRSYC
LAKFKRKSSH NISCAIIFLS VLYMSISSHL FISITATLNL TMNNFLYVSQ SCSLLPLSYL
MQSMYSTLLV LREVFLIGLM VLSTSYMVAL LCMHRKQAQN LQGTSLSLKT APEQRATQTI
LMLMTFFVLM SIFDSIVSSS RAMFLDDSTC YSIYIFVMHI YATVSPFVFM STEKHLVNFF
RSMCEWIINM
