V1R48_MOUSE
ID V1R48_MOUSE Reviewed; 302 AA.
AC Q9EQ52;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Vomeronasal type-1 receptor 48;
DE AltName: Full=Vomeronasal type-1 receptor A3;
DE AltName: Full=Vomeronasal type-1 receptor A6;
GN Name=Vmn1r48; Synonyms=V1ra3, V1ra6 {ECO:0000312|EMBL:BAB79212.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAG42076.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42076.1};
RX PubMed=11116090; DOI=10.1101/gr.10.12.1958;
RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.;
RT "Sequence diversity and genomic organization of vomeronasal receptor genes
RT in the mouse.";
RL Genome Res. 10:1958-1967(2000).
RN [2] {ECO:0000312|EMBL:BAB79212.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Sam M., Matsunami H., Buck L.;
RT "Vomeronasal receptor gene diversity in the mammalian genome.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000305}
RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12214233; DOI=10.1038/nature00955;
RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA Ogawa S., Zufall F., Mombaerts P.;
RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT receptor genes.";
RL Nature 419:70-74(2002).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social and reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12%
CC of the V1r repertoire) show a lack of chemosensory response to a subset
CC of known pheromonal ligands and changes in maternal aggression as well
CC as male reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF291482; AAG42076.1; -; Genomic_DNA.
DR EMBL; AB062894; BAB79212.1; -; Genomic_DNA.
DR CCDS; CCDS20350.1; -.
DR RefSeq; NP_444448.1; NM_053218.1.
DR AlphaFoldDB; Q9EQ52; -.
DR SMR; Q9EQ52; -.
DR STRING; 10090.ENSMUSP00000073121; -.
DR GlyGen; Q9EQ52; 1 site.
DR PaxDb; Q9EQ52; -.
DR PRIDE; Q9EQ52; -.
DR DNASU; 113845; -.
DR Ensembl; ENSMUST00000073415; ENSMUSP00000073121; ENSMUSG00000057592.
DR GeneID; 113845; -.
DR KEGG; mmu:113845; -.
DR UCSC; uc009cws.1; mouse.
DR CTD; 113845; -.
DR MGI; MGI:2148508; Vmn1r48.
DR VEuPathDB; HostDB:ENSMUSG00000057592; -.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR GeneTree; ENSGT01030000234553; -.
DR HOGENOM; CLU_058641_0_0_1; -.
DR InParanoid; Q9EQ52; -.
DR OMA; LMFICTE; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q9EQ52; -.
DR BioGRID-ORCS; 113845; 2 hits in 33 CRISPR screens.
DR PRO; PR:Q9EQ52; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9EQ52; protein.
DR Genevisible; Q9EQ52; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..302
FT /note="Vomeronasal type-1 receptor 48"
FT /id="PRO_0000239958"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..91
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 92..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..302
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 85..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 302 AA; 34263 MW; EC0CB056AD9F9F0D CRC64;
MNENSRLHTH SNIRNTFFSE IGIGISGNSF LLLFHIIKFF RGHRPRLTDL PIGLLSLIHL
LMLLVAAVIA TDIFISWRGW NDIICKFLVY LYRSLRGLSL CTTSMLSVLQ AIILSPRSYC
LAKFKRKSSH NISCAIIFLS VLYMSISSHL LISITATPNL TMNDFLYVSQ SCSLLPLSYL
MQSIYSTLLV LREVFLIGLM VLSTSYMVAL LYMHRKQAQN LQGTSLSLKA SAEQRATQTI
LMLMTFFVLM SIFDSIVSCS RTMFLDDPTS YSIHIFVMHI YATVSPFVFI STEKHIVNIL
RG
