V1R49_MOUSE
ID V1R49_MOUSE Reviewed; 310 AA.
AC Q9WUF1;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1999, sequence version 1.
DT 03-AUG-2022, entry version 127.
DE RecName: Full=Vomeronasal type-1 receptor 49;
DE AltName: Full=Vomeronasal receptor VRi2;
DE AltName: Full=Vomeronasal type-1 receptor B2;
GN Name=Vmn1r49; Synonyms=V1rb2;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAD28626.1}
RP NUCLEOTIDE SEQUENCE [MRNA], PUTATIVE FUNCTION, TISSUE SPECIFICITY, AND
RP DISRUPTION PHENOTYPE.
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAD28626.1};
RX PubMed=10219241; DOI=10.1016/s0092-8674(00)80730-8;
RA Rodriguez I., Feinstein P., Mombaerts P.;
RT "Variable patterns of axonal projections of sensory neurons in the mouse
RT vomeronasal system.";
RL Cell 97:199-208(1999).
RN [2] {ECO:0000312|EMBL:AAG42084.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42084.1};
RX PubMed=11116090; DOI=10.1101/gr.10.12.1958;
RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.;
RT "Sequence diversity and genomic organization of vomeronasal receptor genes
RT in the mouse.";
RL Genome Res. 10:1958-1967(2000).
RN [3] {ECO:0000305}
RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12214233; DOI=10.1038/nature00955;
RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA Ogawa S., Zufall F., Mombaerts P.;
RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT receptor genes.";
RL Nature 419:70-74(2002).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social and reproductive behavior. {ECO:0000269|PubMed:10219241,
CC ECO:0000269|PubMed:12214233}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in a subset of sensory neurons located in
CC the apical layer of the vomeronasal organ.
CC {ECO:0000269|PubMed:10219241}.
CC -!- DISRUPTION PHENOTYPE: Mice show a disrupted pattern of axonal
CC projections to the accessory olfactory bulb. Mice lacking all but one
CC V1ra and V1rb gene (12% of the V1r repertoire) show a lack of
CC chemosensory response to a subset of known pheromonal ligands and
CC changes in maternal aggression as well as male reproductive behavior.
CC {ECO:0000269|PubMed:10219241, ECO:0000269|PubMed:12214233}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF132114; AAD28626.1; -; mRNA.
DR EMBL; AF291490; AAG42084.1; -; Genomic_DNA.
DR CCDS; CCDS20351.1; -.
DR RefSeq; NP_036041.1; NM_011911.1.
DR RefSeq; XP_006506128.1; XM_006506065.1.
DR AlphaFoldDB; Q9WUF1; -.
DR SMR; Q9WUF1; -.
DR STRING; 10090.ENSMUSP00000071762; -.
DR GlyGen; Q9WUF1; 2 sites.
DR iPTMnet; Q9WUF1; -.
DR PhosphoSitePlus; Q9WUF1; -.
DR PaxDb; Q9WUF1; -.
DR PRIDE; Q9WUF1; -.
DR DNASU; 24112; -.
DR Ensembl; ENSMUST00000071865; ENSMUSP00000071762; ENSMUSG00000095932.
DR Ensembl; ENSMUST00000203791; ENSMUSP00000145107; ENSMUSG00000095932.
DR Ensembl; ENSMUST00000226368; ENSMUSP00000154456; ENSMUSG00000095932.
DR GeneID; 24112; -.
DR KEGG; mmu:24112; -.
DR UCSC; uc009cwt.1; mouse.
DR CTD; 24112; -.
DR MGI; MGI:1344384; Vmn1r49.
DR VEuPathDB; HostDB:ENSMUSG00000095932; -.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR GeneTree; ENSGT01030000234553; -.
DR HOGENOM; CLU_058641_0_0_1; -.
DR InParanoid; Q9WUF1; -.
DR OMA; ALTHIMM; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q9WUF1; -.
DR BioGRID-ORCS; 24112; 1 hit in 69 CRISPR screens.
DR PRO; PR:Q9WUF1; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9WUF1; protein.
DR Bgee; ENSMUSG00000095932; Expressed in bone marrow and 19 other tissues.
DR Genevisible; Q9WUF1; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Vomeronasal type-1 receptor 49"
FT /id="PRO_0000239974"
FT TOPO_DOM 1..12
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 13..33
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 34..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..190
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 81
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 85..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 310 AA; 35523 MW; 65F9A3F4B44A1011 CRC64;
MSKANLLHTD NNMKIILFSE VSVGISANTI LFFARLCKLL GENKPKPIDL YIAFLSLTQL
MLLITMGLIA VDMFMPWGRW NSTTCQSLIY LHRLLRGLAL SATCLLNVLW TITLSSRSSC
LTKFKHKSPH HISGAFLFFY VLYMSFSSHV LVSIIVTPNL TSEDFMYVTQ SCSLLPMSYS
RESRFSTLMA IRETFLISLM ALSSGYMVAL LWRHKKQAQH LRSTSLSSKA SPEQRATRTI
MLLTSLFVVL YILERVVFQS RLKFKDCSVF YFVHIIMSHS YATVSPFVFI CTEKHIIKFW
ESIFGRIVNI
