V1R50_MOUSE
ID V1R50_MOUSE Reviewed; 310 AA.
AC Q9EP51; Q8VIC3;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 121.
DE RecName: Full=Vomeronasal type-1 receptor 50;
DE AltName: Full=Pheromone receptor VN2;
DE AltName: Full=Vomeronasal receptor 2;
DE AltName: Full=Vomeronasal type-1 receptor A5;
DE AltName: Full=Vomeronasal type-1 receptor B1;
GN Name=Vmn1r50; Synonyms=V1ra5 {ECO:0000312|EMBL:BAB79219.1}, V1rb1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAG42083.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42083.1};
RX PubMed=11116090; DOI=10.1101/gr.10.12.1958;
RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.;
RT "Sequence diversity and genomic organization of vomeronasal receptor genes
RT in the mouse.";
RL Genome Res. 10:1958-1967(2000).
RN [2] {ECO:0000312|EMBL:AAG43248.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11752409; DOI=10.1073/pnas.012608399;
RA Lane R.P., Cutforth T., Axel R., Hood L., Trask B.J.;
RT "Sequence analysis of mouse vomeronasal receptor gene clusters reveals
RT common promoter motifs and a history of recent expansion.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:291-296(2002).
RN [3] {ECO:0000312|EMBL:BAB79219.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Sam M., Matsunami H., Buck L.;
RT "Vomeronasal receptor gene diversity in the mammalian genome.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAI07184.1}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [5] {ECO:0000305}
RP PUTATIVE FUNCTION, TISSUE SPECIFICITY, AND DISRUPTION PHENOTYPE.
RX PubMed=12214233; DOI=10.1038/nature00955;
RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA Ogawa S., Zufall F., Mombaerts P.;
RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT receptor genes.";
RL Nature 419:70-74(2002).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social and reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in a subset of sensory neurons located in
CC the apical layer of the vomeronasal organ.
CC {ECO:0000269|PubMed:12214233}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12%
CC of the V1r repertoire) show a lack of chemosensory response to a subset
CC of known pheromonal ligands and changes in maternal aggression as well
CC as male reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF291489; AAG42083.1; -; Genomic_DNA.
DR EMBL; AF129005; AAG43248.1; -; Genomic_DNA.
DR EMBL; AB062902; BAB79219.1; -; Genomic_DNA.
DR EMBL; BC107183; AAI07184.1; -; mRNA.
DR CCDS; CCDS20352.1; -.
DR RefSeq; NP_444455.1; NM_053225.1.
DR AlphaFoldDB; Q9EP51; -.
DR SMR; Q9EP51; -.
DR STRING; 10090.ENSMUSP00000080407; -.
DR GlyGen; Q9EP51; 1 site.
DR iPTMnet; Q9EP51; -.
DR PhosphoSitePlus; Q9EP51; -.
DR PaxDb; Q9EP51; -.
DR PRIDE; Q9EP51; -.
DR DNASU; 113852; -.
DR Ensembl; ENSMUST00000081706; ENSMUSP00000080407; ENSMUSG00000094553.
DR Ensembl; ENSMUST00000089417; ENSMUSP00000100705; ENSMUSG00000094553.
DR Ensembl; ENSMUST00000226577; ENSMUSP00000154560; ENSMUSG00000094553.
DR GeneID; 113852; -.
DR KEGG; mmu:113852; -.
DR UCSC; uc009cwu.1; mouse.
DR CTD; 113852; -.
DR MGI; MGI:2148515; Vmn1r50.
DR VEuPathDB; HostDB:ENSMUSG00000094553; -.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR GeneTree; ENSGT01030000234553; -.
DR HOGENOM; CLU_058641_0_0_1; -.
DR InParanoid; Q9EP51; -.
DR OMA; TENVFEI; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q9EP51; -.
DR BioGRID-ORCS; 113852; 2 hits in 36 CRISPR screens.
DR PRO; PR:Q9EP51; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9EP51; protein.
DR Bgee; ENSMUSG00000094553; Expressed in nucleus of brain and 9 other tissues.
DR Genevisible; Q9EP51; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Vomeronasal type-1 receptor 50"
FT /id="PRO_0000239973"
FT TOPO_DOM 1..16
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 17..37
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 38..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..237
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 238..258
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 259..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 85..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 115
FT /note="S -> N (in Ref. 3; BAB79219)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 310 AA; 35195 MW; FBC10A7152FD5957 CRC64;
MSKANLLHTD NNMKITLFSE VSVGISANSI LFVVHLCKLL HENKPKPIDL YIAFFSITQL
MLLITMGLIA VDMFMPWGRW DSTTCQSLIY LHRLLRGLTF CATCLLNVLW TITLSPRSSC
LTKFKHKSPH HISGAFLFFC VLYMSFSSHL LVSIIATFNS TSDNFLYVTQ SCSILPVSYS
RTSILSTMMT MREAFLIGLM ALSSGYVVVL LWRHKKQARH LHSTSLSSKA SPEQRATSTI
MLLMGFFVVL YILDTVIFQA RLKFKDVSTF FCVKIIISHS YATFSPFVFI CNDKYMIKFV
TSMCGRIVNV
