V1R51_MOUSE
ID V1R51_MOUSE Reviewed; 319 AA.
AC Q8VIC6; Q9EPA4; Q9Z195;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 13-JUN-2006, sequence version 2.
DT 03-AUG-2022, entry version 112.
DE RecName: Full=Vomeronasal type-1 receptor 51;
DE AltName: Full=Pheromone receptor 1;
DE AltName: Full=Vomeronasal type-1 receptor A1;
DE Short=mV1R1;
DE AltName: Full=Vomeronasal type-1 receptor A8;
GN Name=Vmn1r51;
GN Synonyms=Pr1 {ECO:0000312|EMBL:CAA73257.1}, V1ra1,
GN V1ra8 {ECO:0000312|EMBL:BAB79215.1};
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000305, ECO:0000312|EMBL:CAA73257.1}
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC STRAIN=BALB/cJ {ECO:0000312|EMBL:CAA73257.1};
RX PubMed=9757043; DOI=10.1016/s0169-328x(98)00183-1;
RA Saito H., Mimmack M.L., Keverne E.B., Kishimoto J., Emson P.C.;
RT "Isolation of mouse vomeronasal receptor genes and their co-localization
RT with specific G-protein messenger RNAs.";
RL Brain Res. Mol. Brain Res. 60:215-227(1998).
RN [2] {ECO:0000312|EMBL:AAG43249.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11752409; DOI=10.1073/pnas.012608399;
RA Lane R.P., Cutforth T., Axel R., Hood L., Trask B.J.;
RT "Sequence analysis of mouse vomeronasal receptor gene clusters reveals
RT common promoter motifs and a history of recent expansion.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:291-296(2002).
RN [3] {ECO:0000312|EMBL:BAB79215.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Sam M., Matsunami H., Buck L.;
RT "Vomeronasal receptor gene diversity in the mammalian genome.";
RL Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000312|EMBL:AAG42075.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 17-319.
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42075.1};
RX PubMed=11116090; DOI=10.1101/gr.10.12.1958;
RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.;
RT "Sequence diversity and genomic organization of vomeronasal receptor genes
RT in the mouse.";
RL Genome Res. 10:1958-1967(2000).
RN [5] {ECO:0000305}
RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12214233; DOI=10.1038/nature00955;
RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA Ogawa S., Zufall F., Mombaerts P.;
RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT receptor genes.";
RL Nature 419:70-74(2002).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social as well as reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in a subset of sensory neurons located in
CC the apical layer of the vomeronasal organ.
CC {ECO:0000269|PubMed:9757043}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12%
CC of the V1r repertoire) show a lack of chemosensory response to a subset
CC of known pheromonal ligands and changes in maternal aggression as well
CC as male reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAG43249.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=BAB79215.1; Type=Erroneous initiation; Evidence={ECO:0000305};
CC Sequence=CAA73257.1; Type=Erroneous initiation; Evidence={ECO:0000305};
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DR EMBL; Y12725; CAA73257.1; ALT_INIT; mRNA.
DR EMBL; AF129005; AAG43249.1; ALT_INIT; Genomic_DNA.
DR EMBL; AB062897; BAB79215.1; ALT_INIT; Genomic_DNA.
DR EMBL; AF291481; AAG42075.1; -; Genomic_DNA.
DR RefSeq; NP_035813.2; NM_011683.2.
DR AlphaFoldDB; Q8VIC6; -.
DR SMR; Q8VIC6; -.
DR STRING; 10090.ENSMUSP00000133870; -.
DR GlyGen; Q8VIC6; 1 site.
DR PaxDb; Q8VIC6; -.
DR PRIDE; Q8VIC6; -.
DR DNASU; 22296; -.
DR GeneID; 22296; -.
DR KEGG; mmu:22296; -.
DR CTD; 22296; -.
DR MGI; MGI:1333759; Vmn1r51.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR InParanoid; Q8VIC6; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q8VIC6; -.
DR BioGRID-ORCS; 22296; 1 hit in 68 CRISPR screens.
DR PRO; PR:Q8VIC6; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q8VIC6; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..319
FT /note="Vomeronasal type-1 receptor 51"
FT /id="PRO_0000239955"
FT TOPO_DOM 1..31
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 32..52
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 53..65
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 66..86
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 87..109
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 110..130
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 131..150
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 151..171
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 172..203
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 204..224
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 225..254
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 255..275
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 276..285
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 286..306
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 307..319
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 175
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 101..188
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 17
FT /note="M -> MM (in Ref. 1; CAA73257)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 319 AA; 36533 MW; 6F42DE9DBCA02261 CRC64;
MNEILFFSPQ PLFSHMMNEN SRVHTHSNLR HIFFSEIGIG ISGNSFLLLF HILKFIHGHR
SRLSDLPIGL LSLIHLLMLL VMAFIATDIF ISWRGWDDII CKFLVYLYRV LRGLSLCTTS
MLSVLQAIIL SPRSSCLAKF KRKSLHHISC AILFLSVLYM LIGSQLLVSI IATPNLTTND
FIYVTQSCSI LPLSYVMQSM FSTLLVIRDV FLISLMVLST WYMVALLCRH RKKTQHLQGI
SLSPKTSPKQ RATQTLLMLM SFFVLMTIYD TIVSCSRTMF LNDPTSYNMQ IFVVHIYATV
SPFVFMSTEK HIVNCLRSV
