V1R52_MOUSE
ID V1R52_MOUSE Reviewed; 309 AA.
AC Q9EP79;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 115.
DE RecName: Full=Vomeronasal type-1 receptor 52;
DE AltName: Full=Pheromone receptor VN3;
DE AltName: Full=Vomeronasal receptor 3;
DE AltName: Full=Vomeronasal type-1 receptor A7;
GN Name=Vmn1r52; Synonyms=V1ra7;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAG42080.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42080.1};
RX PubMed=11116090; DOI=10.1101/gr.10.12.1958;
RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.;
RT "Sequence diversity and genomic organization of vomeronasal receptor genes
RT in the mouse.";
RL Genome Res. 10:1958-1967(2000).
RN [2] {ECO:0000312|EMBL:AAG43250.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11752409; DOI=10.1073/pnas.012608399;
RA Lane R.P., Cutforth T., Axel R., Hood L., Trask B.J.;
RT "Sequence analysis of mouse vomeronasal receptor gene clusters reveals
RT common promoter motifs and a history of recent expansion.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:291-296(2002).
RN [3] {ECO:0000305}
RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12214233; DOI=10.1038/nature00955;
RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA Ogawa S., Zufall F., Mombaerts P.;
RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT receptor genes.";
RL Nature 419:70-74(2002).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social and reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12%
CC of the V1r repertoire) show a lack of chemosensory response to a subset
CC of known pheromonal ligands and changes in maternal aggression as well
CC as male reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF291486; AAG42080.1; -; Genomic_DNA.
DR EMBL; AF129005; AAG43250.1; -; Genomic_DNA.
DR CCDS; CCDS20353.1; -.
DR RefSeq; NP_444452.1; NM_053222.1.
DR AlphaFoldDB; Q9EP79; -.
DR SMR; Q9EP79; -.
DR GlyGen; Q9EP79; 1 site.
DR PaxDb; Q9EP79; -.
DR PRIDE; Q9EP79; -.
DR DNASU; 113849; -.
DR Ensembl; ENSMUST00000079832; ENSMUSP00000078760; ENSMUSG00000060816.
DR Ensembl; ENSMUST00000226520; ENSMUSP00000154082; ENSMUSG00000060816.
DR Ensembl; ENSMUST00000227893; ENSMUSP00000154024; ENSMUSG00000060816.
DR Ensembl; ENSMUST00000228394; ENSMUSP00000153951; ENSMUSG00000060816.
DR Ensembl; ENSMUST00000228665; ENSMUSP00000154275; ENSMUSG00000060816.
DR GeneID; 113849; -.
DR KEGG; mmu:113849; -.
DR UCSC; uc009cww.1; mouse.
DR CTD; 113849; -.
DR MGI; MGI:2148512; Vmn1r52.
DR VEuPathDB; HostDB:ENSMUSG00000060816; -.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR GeneTree; ENSGT01030000234553; -.
DR HOGENOM; CLU_058641_0_0_1; -.
DR InParanoid; Q9EP79; -.
DR OMA; CIQILMA; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q9EP79; -.
DR BioGRID-ORCS; 113849; 3 hits in 32 CRISPR screens.
DR PRO; PR:Q9EP79; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9EP79; protein.
DR Bgee; ENSMUSG00000060816; Expressed in lung.
DR ExpressionAtlas; Q9EP79; differential.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..309
FT /note="Vomeronasal type-1 receptor 52"
FT /id="PRO_0000239962"
FT TOPO_DOM 1..19
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..187
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 188..208
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 209..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..309
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 85..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 309 AA; 35050 MW; 918D81704C2EF267 CRC64;
MNKDHTLYCS VYIRNAFFSE IGIGISANSC LLLFHTFMFI RGHRPRLTDL PIGFVALIHL
VMLLLAAYIT EDFFMSSGGW DDITCKLVIF LHRFFRSLSV CATCLLSVFQ AIILCPQSSH
LAKLKQNSPH QLSYFFIFLS IFYTSISSHI LIAAIPTQNI TFVNLIYITN SCSFLPLSSS
MQHTFSTLLA FRNVFVIGLM GLSTCYMATL LCRHKTRSQR LQNSKLSPKA TPEQRALRTI
LMLMSFFLLM STFDSIISYS RTILQGNPLP FCFQILVAHS YAAVSPLLVL SNEKRITNLL
ISMYEKIVL
