V1R53_MOUSE
ID V1R53_MOUSE Reviewed; 310 AA.
AC Q9EP93; Q059M1;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 25-MAY-2022, entry version 101.
DE RecName: Full=Vomeronasal type-1 receptor 53;
DE AltName: Full=Pheromone receptor VN5;
DE AltName: Full=Vomeronasal receptor 5;
DE AltName: Full=Vomeronasal type-1 receptor B3;
GN Name=Vmn1r53; Synonyms=V1rb3;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAG42085.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42085.1};
RX PubMed=11116090; DOI=10.1101/gr.10.12.1958;
RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.;
RT "Sequence diversity and genomic organization of vomeronasal receptor genes
RT in the mouse.";
RL Genome Res. 10:1958-1967(2000).
RN [2] {ECO:0000312|EMBL:AAG43251.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11752409; DOI=10.1073/pnas.012608399;
RA Lane R.P., Cutforth T., Axel R., Hood L., Trask B.J.;
RT "Sequence analysis of mouse vomeronasal receptor gene clusters reveals
RT common promoter motifs and a history of recent expansion.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:291-296(2002).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Brain;
RX PubMed=15489334; DOI=10.1101/gr.2596504;
RG The MGC Project Team;
RT "The status, quality, and expansion of the NIH full-length cDNA project:
RT the Mammalian Gene Collection (MGC).";
RL Genome Res. 14:2121-2127(2004).
RN [4] {ECO:0000305}
RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12214233; DOI=10.1038/nature00955;
RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA Ogawa S., Zufall F., Mombaerts P.;
RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT receptor genes.";
RL Nature 419:70-74(2002).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social and reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12%
CC of the V1r repertoire) show a lack of chemosensory response to a subset
CC of known pheromonal ligands and changes in maternal aggression as well
CC as male reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- CAUTION: Was found to lack a conserved putative promoter and,
CC therefore, may not be transcribed. {ECO:0000305|PubMed:11752409}.
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DR EMBL; AF291491; AAG42085.1; -; Genomic_DNA.
DR EMBL; AF129005; AAG43251.1; -; Genomic_DNA.
DR EMBL; BC125605; AAI25606.1; -; mRNA.
DR CCDS; CCDS20355.1; -.
DR AlphaFoldDB; Q9EP93; -.
DR SMR; Q9EP93; -.
DR STRING; 10090.ENSMUSP00000075455; -.
DR GlyGen; Q9EP93; 1 site.
DR iPTMnet; Q9EP93; -.
DR PhosphoSitePlus; Q9EP93; -.
DR PaxDb; Q9EP93; -.
DR PRIDE; Q9EP93; -.
DR MGI; MGI:2148516; Vmn1r53.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR InParanoid; Q9EP93; -.
DR PhylomeDB; Q9EP93; -.
DR PRO; PR:Q9EP93; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; Q9EP93; protein.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Vomeronasal type-1 receptor 53"
FT /id="PRO_0000239975"
FT TOPO_DOM 1..20
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..50
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 51..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..268
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 269..289
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 290..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 85..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 310 AA; 35399 MW; 7092DE1E6D8175AF CRC64;
MNKANLLHTD INLKITLFSE VSVGISANSI LIFAHLCMLL GENRPKPIDL YIAFFSLTQL
MLLITMGLIA VDMFMPWGRW DSTTCQSLIY LHRLLRGLTL SATCLLNVLW TITLSPRSSC
LTKFKHKSLQ HISCAFLFLC VLYMSFNSHL FISIIAYPNL TLENFMYVTQ SCSLIPLSYF
RKSMFSIPMA IREALLIGLM ALSGGYMVAH LWRHKKQAQH LHRTSLSSKA SPEQRATRTI
MLLMSFFVVL YILDLVIFHS RMKFKDGSIL YGVQIIVSHS YATVSPFVFI CTEKRITNFL
RSMCGRIVNI
