V1R54_MOUSE
ID V1R54_MOUSE Reviewed; 315 AA.
AC Q9EPB8;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2001, sequence version 1.
DT 03-AUG-2022, entry version 117.
DE RecName: Full=Vomeronasal type-1 receptor 54;
DE AltName: Full=Pheromone receptor VN7;
DE AltName: Full=Vomeronasal receptor 7;
DE AltName: Full=Vomeronasal type-1 receptor A9;
GN Name=Vmn1r54; Synonyms=V1ra9;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1] {ECO:0000312|EMBL:AAG42082.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RC STRAIN=129/SvJ {ECO:0000312|EMBL:AAG42082.1};
RX PubMed=11116090; DOI=10.1101/gr.10.12.1958;
RA Del Punta K., Rothman A., Rodriguez I., Mombaerts P.;
RT "Sequence diversity and genomic organization of vomeronasal receptor genes
RT in the mouse.";
RL Genome Res. 10:1958-1967(2000).
RN [2] {ECO:0000312|EMBL:AAG43252.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RX PubMed=11752409; DOI=10.1073/pnas.012608399;
RA Lane R.P., Cutforth T., Axel R., Hood L., Trask B.J.;
RT "Sequence analysis of mouse vomeronasal receptor gene clusters reveals
RT common promoter motifs and a history of recent expansion.";
RL Proc. Natl. Acad. Sci. U.S.A. 99:291-296(2002).
RN [3] {ECO:0000305}
RP PUTATIVE FUNCTION, AND DISRUPTION PHENOTYPE.
RX PubMed=12214233; DOI=10.1038/nature00955;
RA Del Punta K., Leinders-Zufall T., Rodriguez I., Jukam D., Wysocki C.J.,
RA Ogawa S., Zufall F., Mombaerts P.;
RT "Deficient pheromone responses in mice lacking a cluster of vomeronasal
RT receptor genes.";
RL Nature 419:70-74(2002).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social and reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- DISRUPTION PHENOTYPE: Mice lacking all but one V1ra and V1rb gene (12%
CC of the V1r repertoire) show a lack of chemosensory response to a subset
CC of known pheromonal ligands and changes in maternal aggression as well
CC as male reproductive behavior. {ECO:0000269|PubMed:12214233}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; AF291488; AAG42082.1; -; Genomic_DNA.
DR EMBL; AF129005; AAG43252.1; -; Genomic_DNA.
DR CCDS; CCDS20356.1; -.
DR RefSeq; NP_444454.1; NM_053224.1.
DR AlphaFoldDB; Q9EPB8; -.
DR SMR; Q9EPB8; -.
DR STRING; 10090.ENSMUSP00000063052; -.
DR PaxDb; Q9EPB8; -.
DR PRIDE; Q9EPB8; -.
DR ProteomicsDB; 298268; -.
DR DNASU; 113851; -.
DR Ensembl; ENSMUST00000058039; ENSMUSP00000063052; ENSMUSG00000047203.
DR Ensembl; ENSMUST00000226921; ENSMUSP00000154354; ENSMUSG00000047203.
DR GeneID; 113851; -.
DR KEGG; mmu:113851; -.
DR UCSC; uc009cwz.1; mouse.
DR CTD; 113851; -.
DR MGI; MGI:2148514; Vmn1r54.
DR VEuPathDB; HostDB:ENSMUSG00000047203; -.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR GeneTree; ENSGT01030000234553; -.
DR HOGENOM; CLU_058641_0_0_1; -.
DR InParanoid; Q9EPB8; -.
DR OMA; ATICPFL; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q9EPB8; -.
DR BioGRID-ORCS; 113851; 3 hits in 67 CRISPR screens.
DR PRO; PR:Q9EPB8; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q9EPB8; protein.
DR Bgee; ENSMUSG00000047203; Expressed in digastric muscle group and 1 other tissue.
DR Genevisible; Q9EPB8; MM.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; TAS:MGI.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 3: Inferred from homology;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Membrane;
KW Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..315
FT /note="Vomeronasal type-1 receptor 54"
FT /id="PRO_0000239966"
FT TOPO_DOM 1..15
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 16..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..51
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 52..71
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 72..90
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 91..112
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 113..132
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 133..154
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 155..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..212
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 213..239
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 240..260
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 261..267
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 268..288
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 289..315
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT DISULFID 85..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
SQ SEQUENCE 315 AA; 35854 MW; 1D6A41D0FEBB6C93 CRC64;
MNKMNRLSHN TEIRNAIYSG VGIGISGNSF LLLFHIFKYI RGQRSRHIDL PIGLLSLIHL
VMLIAMSLVA TDIFMPWGRW GDTTCKCVIS LYRFCRSLSL CATSLLSILQ AVTLNPRNSC
LEKFKRKSPH YMLGCLLFLS VFYTFISSPL ATYITAKSNL TSPSFTYITT SCSLAPMSYS
FHLTVFILLT SRDVIFVGLM LLSSGYMVTF LGRHKKQSQF LHITSFSLKP SAEKRAMRTI
LCLMSFFVLM YTLDSIVSYI RSIDDGQIFY CVHIFTAHGY ATVSPFLILS TEKYIINIFR
STFGRMVTII LLRNR
