V1R90_RAT
ID V1R90_RAT Reviewed; 310 AA.
AC Q5J3F6; Q62855;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 106.
DE RecName: Full=Vomeronasal type-1 receptor 90;
DE AltName: Full=Pheromone receptor VN6;
DE AltName: Full=Vomeronasal receptor 6;
DE AltName: Full=Vomeronasal type-1 receptor A16;
GN Name=Vom1r90; Synonyms=V1ra16;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAC52287.1}
RP NUCLEOTIDE SEQUENCE [MRNA], PUTATIVE FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAC52287.1};
RC TISSUE=Vomeronasal organ {ECO:0000312|EMBL:AAC52287.1};
RX PubMed=7585937; DOI=10.1016/0092-8674(95)90161-2;
RA Dulac C., Axel R.;
RT "A novel family of genes encoding putative pheromone receptors in
RT mammals.";
RL Cell 83:195-206(1995).
RN [2] {ECO:0000312|EMBL:AAR88021.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Capello L., Rodriguez I.;
RT "Rat vomeronasal receptors.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social as well as reproductive behavior. {ECO:0000250|UniProtKB:Q8VIC6,
CC ECO:0000269|PubMed:7585937}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in 1-4% of neurons of the vomeronasal
CC organ. Only one pheromone receptor gene may be expressed in a
CC particular neuron. Not expressed in the main olfactory epithelium.
CC {ECO:0000269|PubMed:7585937}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
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DR EMBL; U36898; AAC52287.1; -; mRNA.
DR EMBL; AY510354; AAR88021.1; -; mRNA.
DR PIR; I61748; I61748.
DR RefSeq; NP_714951.1; NM_153729.2.
DR AlphaFoldDB; Q5J3F6; -.
DR SMR; Q5J3F6; -.
DR STRING; 10116.ENSRNOP00000023832; -.
DR GlyGen; Q5J3F6; 1 site.
DR PaxDb; Q5J3F6; -.
DR Ensembl; ENSRNOT00000083168; ENSRNOP00000071886; ENSRNOG00000058136.
DR Ensembl; ENSRNOT00000108893; ENSRNOP00000087854; ENSRNOG00000058136.
DR GeneID; 266771; -.
DR KEGG; rno:266771; -.
DR UCSC; RGD:708509; rat.
DR CTD; 266771; -.
DR RGD; 708509; Vom1r90.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR GeneTree; ENSGT01030000234553; -.
DR HOGENOM; CLU_058641_0_0_1; -.
DR InParanoid; Q5J3F6; -.
DR OMA; SVITIRY; -.
DR OrthoDB; 1390012at2759; -.
DR PhylomeDB; Q5J3F6; -.
DR PRO; PR:Q5J3F6; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Genevisible; Q5J3F6; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Vomeronasal type-1 receptor 90"
FT /id="PRO_0000239972"
FT TOPO_DOM 1..20
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..46
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 47..67
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 68..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..135
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 136..156
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 157..183
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 184..204
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 205..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..271
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..292
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 85..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 183
FT /note="H -> D (in Ref. 1; AAC52287)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 310 AA; 35324 MW; 3CC07BA274AB7CFA CRC64;
MRRISTLYGV VDKQAIFFSE VVIGISFNSI LFLFHIFQFL LERRLRITDL IISLLALIHL
GMLTVMGFRA VDIFASQNVW NDIKCKSLAH LHRLLRGLSL CATCLLSIFQ AITLSPRSSC
LAKFKYKSTQ HSLCSLLVLW AFYMSCGTHY SFTIVADYNF SSRSLIFVTE SCIILPMDYI
TRHLFFILGI FRDVSFIGLM ALSSGYMVAL LCRHRKQAQH LHRTSLSPKA SPEQRATRTI
LLLMSFFVLM YCLDCTISAS RLMHNGEPIH HSIQMMVSNS YATLSPLLLI VTENRISRFL
KSLLGRTVDA
