V1R93_RAT
ID V1R93_RAT Reviewed; 310 AA.
AC Q5J3L7; Q62853; Q9WUU2;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 100.
DE RecName: Full=Vomeronasal type-1 receptor 93;
DE AltName: Full=M21 pheromone receptor;
DE AltName: Full=Pheromone receptor VN4;
DE AltName: Full=Vomeronasal receptor 4;
DE AltName: Full=Vomeronasal type-1 receptor B5;
DE AltName: Full=mV1R3;
GN Name=Vom1r93; Synonyms=V1rb5;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000305, ECO:0000312|EMBL:AAC52285.1}
RP NUCLEOTIDE SEQUENCE [MRNA], PUTATIVE FUNCTION, AND TISSUE SPECIFICITY.
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAC52285.1};
RC TISSUE=Vomeronasal organ {ECO:0000312|EMBL:AAC52285.1};
RX PubMed=7585937; DOI=10.1016/0092-8674(95)90161-2;
RA Dulac C., Axel R.;
RT "A novel family of genes encoding putative pheromone receptors in
RT mammals.";
RL Cell 83:195-206(1995).
RN [2] {ECO:0000312|EMBL:CAB44235.1}
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Mimmack M.L.;
RL Submitted (JUN-1999) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000312|EMBL:CAB44235.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Capello L., Rodriguez I.;
RT "Rat vomeronasal receptors.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [4] {ECO:0000305}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 1-245.
RX PubMed=9757043; DOI=10.1016/s0169-328x(98)00183-1;
RA Saito H., Mimmack M.L., Keverne E.B., Kishimoto J., Emson P.C.;
RT "Isolation of mouse vomeronasal receptor genes and their co-localization
RT with specific G-protein messenger RNAs.";
RL Brain Res. Mol. Brain Res. 60:215-227(1998).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social as well as reproductive behavior. {ECO:0000250|UniProtKB:Q8VIC6,
CC ECO:0000269|PubMed:7585937}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in 1-4% of neurons of the vomeronasal
CC organ. Only one pheromone receptor gene may be expressed in a
CC particular neuron. Not expressed in the main olfactory epithelium.
CC {ECO:0000269|PubMed:7585937}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255}.
CC -!- CAUTION: Was originally (Ref.2 and PubMed:9757043) thought to originate
CC from mouse. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC52285.1; Type=Erroneous initiation; Note=Extended N-terminus.; Evidence={ECO:0000305};
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; U36896; AAC52285.1; ALT_INIT; mRNA.
DR EMBL; Y17566; CAB44235.1; -; Genomic_DNA.
DR EMBL; AY510293; AAR87960.1; -; mRNA.
DR PIR; I61746; I61746.
DR AlphaFoldDB; Q5J3L7; -.
DR SMR; Q5J3L7; -.
DR GlyGen; Q5J3L7; 1 site.
DR PaxDb; Q5J3L7; -.
DR UCSC; RGD:1549740; rat.
DR RGD; 1549740; Vom1r93.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR HOGENOM; CLU_058641_0_0_1; -.
DR InParanoid; Q5J3L7; -.
DR OMA; YYAEISI; -.
DR PhylomeDB; Q5J3L7; -.
DR PRO; PR:Q5J3L7; -.
DR Proteomes; UP000002494; Chromosome 4.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Vomeronasal type-1 receptor 93"
FT /id="PRO_0000239977"
FT TOPO_DOM 1..20
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 21..41
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 42..59
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 60..80
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 81..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..134
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 135..155
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 156..193
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 194..214
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 215..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 85..172
FT /evidence="ECO:0000250"
FT CONFLICT 34
FT /note="A -> G (in Ref. 1; AAC52285)"
FT /evidence="ECO:0000305"
FT CONFLICT 120
FT /note="R -> C (in Ref. 1; AAC52285)"
FT /evidence="ECO:0000305"
FT CONFLICT 230
FT /note="A -> S (in Ref. 1; AAC52285)"
FT /evidence="ECO:0000305"
FT CONFLICT 305
FT /note="T -> A (in Ref. 1; AAC52285)"
FT /evidence="ECO:0000305"
FT CONFLICT 310
FT /note="I -> N (in Ref. 1; AAC52285)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 310 AA; 35159 MW; 9FF76724C042678B CRC64;
MNKDNTLHVD TIMKITMFSE VSVGILANSI LFFAHLCMLL GENKPKPIHL YIASLSLTQL
MLLITMGLIA ADMFISQGIW DSTSCQSLIY LHRLSRGFTL SAACLLNVFW MITLSSKKSR
LTKFKHNSPH HISGAFLLLC VLYMCFSSHL ILSIIATPNL TSDNFMYVTK SCSFLPMCYS
RTSMFSTTIA VREAFFIGLM ALSSGYLVAF LWRHRKQAQH LHSTGLSSKA SPEQRATETI
LLLMSFFVVL YILENVVFYS RMKFKDGSTF YCVQIIVSHS YATVSSFVFI FTEKRMTKIL
RSVCTRIINI
