V1R97_RAT
ID V1R97_RAT Reviewed; 310 AA.
AC Q5J3M9; Q62854;
DT 13-JUN-2006, integrated into UniProtKB/Swiss-Prot.
DT 15-FEB-2005, sequence version 1.
DT 03-AUG-2022, entry version 91.
DE RecName: Full=Vomeronasal type-1 receptor 97;
DE AltName: Full=Pheromone receptor VN5;
DE AltName: Full=Vomeronasal receptor 5;
DE AltName: Full=Vomeronasal type-1 receptor 41;
DE AltName: Full=Vomeronasal type-1 receptor B12;
DE AltName: Full=Vomeronasal type-1 receptor B9;
GN Name=Vom1r97; Synonyms=V1ra12, V1rb9, Vmn1r41;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1] {ECO:0000312|EMBL:AAR87948.1}
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Capello L., Rodriguez I.;
RT "Rat vomeronasal receptors.";
RL Submitted (DEC-2003) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000305, ECO:0000312|EMBL:AAC52286.1}
RP NUCLEOTIDE SEQUENCE [MRNA] OF 33-310, PUTATIVE FUNCTION, AND TISSUE
RP SPECIFICITY.
RC STRAIN=Sprague-Dawley {ECO:0000312|EMBL:AAC52286.1};
RC TISSUE=Vomeronasal organ {ECO:0000312|EMBL:AAC52286.1};
RX PubMed=7585937; DOI=10.1016/0092-8674(95)90161-2;
RA Dulac C., Axel R.;
RT "A novel family of genes encoding putative pheromone receptors in
RT mammals.";
RL Cell 83:195-206(1995).
CC -!- FUNCTION: Putative pheromone receptor implicated in the regulation of
CC social as well as reproductive behavior. {ECO:0000250|UniProtKB:Q8VIC6,
CC ECO:0000269|PubMed:7585937}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000255}.
CC -!- TISSUE SPECIFICITY: Expressed in 1-4% of neurons of the vomeronasal
CC organ. Only one pheromone receptor gene may be expressed in a
CC particular neuron. Not expressed in the main olfactory epithelium.
CC {ECO:0000269|PubMed:7585937}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC {ECO:0000255|PROSITE-ProRule:PRU00521}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC52286.1; Type=Erroneous initiation; Note=Truncated N-terminus.; Evidence={ECO:0000305};
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DR EMBL; AY510281; AAR87948.1; -; mRNA.
DR EMBL; U36897; AAC52286.1; ALT_INIT; mRNA.
DR PIR; I61747; I61747.
DR AlphaFoldDB; Q5J3M9; -.
DR SMR; Q5J3M9; -.
DR STRING; 10116.ENSRNOP00000060982; -.
DR GlyGen; Q5J3M9; 1 site.
DR PaxDb; Q5J3M9; -.
DR PRIDE; Q5J3M9; -.
DR Ensembl; ENSRNOT00000042796; ENSRNOP00000047657; ENSRNOG00000068663.
DR Ensembl; ENSRNOT00000116872; ENSRNOP00000097028; ENSRNOG00000068663.
DR UCSC; RGD:708391; rat.
DR RGD; 708391; Vom1r97.
DR eggNOG; ENOG502SNRJ; Eukaryota.
DR GeneTree; ENSGT01030000234553; -.
DR HOGENOM; CLU_058641_0_0_1; -.
DR InParanoid; Q5J3M9; -.
DR OMA; TRTIMIL; -.
DR PhylomeDB; Q5J3M9; -.
DR PRO; PR:Q5J3M9; -.
DR Proteomes; UP000002494; Chromosome 4.
DR Genevisible; Q5J3M9; RN.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016503; F:pheromone receptor activity; IEA:InterPro.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR GO; GO:0007606; P:sensory perception of chemical stimulus; IEA:UniProt.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR004072; Vmron_rcpt_1.
DR PANTHER; PTHR24062; PTHR24062; 1.
DR Pfam; PF03402; V1R; 1.
DR PRINTS; PR01534; VOMERONASL1R.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Disulfide bond; G-protein coupled receptor; Glycoprotein;
KW Membrane; Pheromone response; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..310
FT /note="Vomeronasal type-1 receptor 97"
FT /id="PRO_0000239982"
FT TOPO_DOM 1..19
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 20..40
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 41..49
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 50..70
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 71..93
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 94..114
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 115..131
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 132..152
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 153..190
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 191..211
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 212..238
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 239..259
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 260..269
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 270..290
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 291..310
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 159
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT DISULFID 85..172
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00521"
FT CONFLICT 92
FT /note="H -> D (in Ref. 2; AAC52286)"
FT /evidence="ECO:0000305"
FT CONFLICT 170
FT /note="Q -> K (in Ref. 2; AAC52286)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 310 AA; 35286 MW; E8FFE94FD7FEC4EE CRC64;
MNKDNILHTD TNIKITLFSE VSIGISANSA LFFSHLFMLF EKNRSKPIDL YIAFLSLTQL
MLLITIGLIA ADMFMSRGRW DSTTCQSLIY LHRLLRGFTL CATCLLNVLW TITLSPRSSC
LTTFKHKSPH HISGAFLFFC VLYISFGSHL FLSTIATPNL TSDNFMYVTQ SCSFLPMSYS
RTSMFSTPMA IREALLIGLI GLSSGYMVAF LWRHKNQARH LHSTSLSSKV SPEQRATRTI
MILMSFFVVL YILENVVFYS RMTFKDGSMF YCVQIIVSHS YATISPFVFI CTEKRIIKLW
GSMSSRIVSI
