ID   V26AA_XENLA             Reviewed;         326 AA.
AC   Q6IRD0;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   03-AUG-2022, entry version 64.
DE   RecName: Full=Vacuolar protein sorting-associated protein 26A-A;
DE   AltName: Full=Vesicle protein sorting 26A-A;
GN   Name=vps26a-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Embryo;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as component of the retromer cargo-selective complex
CC       (CSC). The CSC is believed to be the core functional component of
CC       retromer or respective retromer complex variants acting to prevent
CC       missorting of selected transmembrane cargo proteins into the lysosomal
CC       degradation pathway. Retromer mediates retrograde transport of cargo
CC       proteins from endosomes to the trans-Golgi network (TGN) (By
CC       similarity). {ECO:0000250|UniProtKB:O75436}.
CC   -!- SUBUNIT: Component of the heterotrimeric retromer cargo-selective
CC       complex (CSC) which is believed to associate with variable sorting
CC       nexins to form functionally distinct retromer complex variants (By
CC       similarity). {ECO:0000250|UniProtKB:O75436}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Endosome membrane; Peripheral membrane
CC       protein. Early endosome {ECO:0000250|UniProtKB:O75436}. Note=Localizes
CC       to tubular profiles adjacent to endosomes (By similarity).
CC       {ECO:0000250|UniProtKB:O75436}.
CC   -!- SIMILARITY: Belongs to the VPS26 family. {ECO:0000305}.
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DR   EMBL; BC070968; AAH70968.1; -; mRNA.
DR   RefSeq; NP_001085024.1; NM_001091555.1.
DR   AlphaFoldDB; Q6IRD0; -.
DR   SMR; Q6IRD0; -.
DR   DNASU; 432091; -.
DR   GeneID; 432091; -.
DR   KEGG; xla:432091; -.
DR   CTD; 432091; -.
DR   Xenbase; XB-GENE-944866; vps26a.L.
DR   OMA; FKQHGKR; -.
DR   OrthoDB; 987411at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 432091; Expressed in zone of skin and 19 other tissues.
DR   GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031982; C:vesicle; ISS:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR028934; Vps26-related.
DR   PANTHER; PTHR12233; PTHR12233; 1.
DR   Pfam; PF03643; Vps26; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..326
FT                   /note="Vacuolar protein sorting-associated protein 26A-A"
FT                   /id="PRO_0000247086"
FT   REGION          306..326
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   326 AA;  38092 MW;  6E1CB83692115829 CRC64;
     MSFLSGFFGP ICEIEVVLND AETRKVSEIK TEEGKVEKHF LFYDGESVAG KVNIVFKQPG
     KRLEHHGIRI EFVGQIELFN DKSNTHEFVN LVKELALPGE LTQSRNYDFE FMQVEKPYES
     YIGSNVRLRY FLKVTIVRRL TDLVKEYDLI VHQLATYPDV NNSIKMEVGI EDCLHIEFEY
     NKSKYHLKDV IVGKIYFLLV RIKIQHMELQ LIKKEITGIG PSTTTETETV AKYEIMDGAP
     VKGESIPIRL FIAGYDPTPT MRDVNKKFSV RYFLNLVLVD EEDRRYFKQQ EIVLWRKAPE
     KIKKRTNFHQ RFEPQEPQAS AEEPEI