ID   V26AB_XENLA             Reviewed;         326 AA.
AC   Q6DFU4;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   03-AUG-2022, entry version 66.
DE   RecName: Full=Vacuolar protein sorting-associated protein 26A-B;
DE   AltName: Full=Vesicle protein sorting 26A-B;
GN   Name=vps26a-b;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Liver;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as component of the retromer cargo-selective complex
CC       (CSC). The CSC is believed to be the core functional component of
CC       retromer or respective retromer complex variants acting to prevent
CC       missorting of selected transmembrane cargo proteins into the lysosomal
CC       degradation pathway. Retromer mediates retrograde transport of cargo
CC       proteins from endosomes to the trans-Golgi network (TGN) (By
CC       similarity). {ECO:0000250|UniProtKB:O75436}.
CC   -!- SUBUNIT: Component of the heterotrimeric retromer cargo-selective
CC       complex (CSC) which is believed to associate with variable sorting
CC       nexins to form functionally distinct retromer complex variants (By
CC       similarity). {ECO:0000250|UniProtKB:O75436}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Endosome membrane; Peripheral membrane
CC       protein. Early endosome {ECO:0000250|UniProtKB:O75436}. Note=Localizes
CC       to tubular profiles adjacent to endosomes (By similarity).
CC       {ECO:0000250|UniProtKB:O75436}.
CC   -!- SIMILARITY: Belongs to the VPS26 family. {ECO:0000305}.
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DR   EMBL; BC076639; AAH76639.1; -; mRNA.
DR   RefSeq; NP_001087092.1; NM_001093623.1.
DR   AlphaFoldDB; Q6DFU4; -.
DR   SMR; Q6DFU4; -.
DR   DNASU; 446981; -.
DR   GeneID; 446981; -.
DR   KEGG; xla:446981; -.
DR   CTD; 446981; -.
DR   Xenbase; XB-GENE-6254832; vps26a.S.
DR   OrthoDB; 987411at2759; -.
DR   Proteomes; UP000186698; Chromosome 7S.
DR   Bgee; 446981; Expressed in zone of skin and 19 other tissues.
DR   GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0005768; C:endosome; ISS:UniProtKB.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0031982; C:vesicle; ISS:UniProtKB.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR028934; Vps26-related.
DR   PANTHER; PTHR12233; PTHR12233; 1.
DR   Pfam; PF03643; Vps26; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..326
FT                   /note="Vacuolar protein sorting-associated protein 26A-B"
FT                   /id="PRO_0000247087"
SQ   SEQUENCE   326 AA;  38018 MW;  959E3F54CB72313C CRC64;
     MSFLSGLFGP ICEIEVALND SDTRKVSEIK TEEGKVEKHF LFYDGESVAG KVNIVFKQPG
     KRLEHHGIRI EFVGQIELFN DKSNTHEFVN LVKELALPGE LTQSRSYDFE FMQVEKPYES
     YNGANVRLRY FLKVTIVRRL TDLVKEYDLI VHQLASYPDV NNSIKMEVGI EDCLHIEFEY
     NKSKYHLKDV IVGKIYFLLV RIKIQHMELQ LIKKEITGIG PSTTTETETV AKYEIMDGAP
     VKGESIPIRL FIAGYDPTPT MRDVNKKFSV RYFLNLVLVD EEDRRYFKQQ EIILWRKAPE
     KIRKRTNFHQ RFEPQEPQAS AEEPEI