ID   V26BA_XENLA             Reviewed;         337 AA.
AC   Q68F29;
DT   25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-OCT-2004, sequence version 1.
DT   03-AUG-2022, entry version 65.
DE   RecName: Full=Vacuolar protein sorting-associated protein 26B-A;
DE   AltName: Full=Vesicle protein sorting 26B-A;
GN   Name=vps26b-a;
OS   Xenopus laevis (African clawed frog).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC   Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX   NCBI_TaxID=8355;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC   TISSUE=Kidney;
RG   NIH - Xenopus Gene Collection (XGC) project;
RL   Submitted (AUG-2004) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Acts as component of the retromer cargo-selective complex
CC       (CSC). The CSC is believed to be the core functional component of
CC       retromer or respective retromer complex variants acting to prevent
CC       missorting of selected transmembrane cargo proteins into the lysosomal
CC       degradation pathway. Retromer mediates retrograde transport of cargo
CC       proteins from endosomes to the trans-Golgi network (TGN) (By
CC       similarity). {ECO:0000250|UniProtKB:O75436}.
CC   -!- SUBUNIT: Component of the heterotrimeric retromer cargo-selective
CC       complex (CSC) which is believed to associate with variable sorting
CC       nexins to form functionally distinct retromer complex variants (By
CC       similarity). {ECO:0000250|UniProtKB:O75436}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm. Endosome membrane; Peripheral membrane
CC       protein. Early endosome {ECO:0000250|UniProtKB:O75436}. Note=Localizes
CC       to tubular profiles adjacent to endosomes (By similarity).
CC       {ECO:0000250|UniProtKB:O75436}.
CC   -!- SIMILARITY: Belongs to the VPS26 family. {ECO:0000305}.
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DR   EMBL; BC080016; AAH80016.1; -; mRNA.
DR   RefSeq; NP_001087500.1; NM_001094031.1.
DR   AlphaFoldDB; Q68F29; -.
DR   SMR; Q68F29; -.
DR   DNASU; 447324; -.
DR   GeneID; 447324; -.
DR   KEGG; xla:447324; -.
DR   CTD; 447324; -.
DR   Xenbase; XB-GENE-6254010; vps26b.L.
DR   OMA; LWVHSYR; -.
DR   OrthoDB; 987411at2759; -.
DR   Proteomes; UP000186698; Chromosome 7L.
DR   Bgee; 447324; Expressed in egg cell and 19 other tissues.
DR   GO; GO:0005769; C:early endosome; IEA:UniProtKB-SubCell.
DR   GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR   Gene3D; 2.60.40.640; -; 2.
DR   InterPro; IPR014752; Arrestin-like_C.
DR   InterPro; IPR028934; Vps26-related.
DR   PANTHER; PTHR12233; PTHR12233; 1.
DR   Pfam; PF03643; Vps26; 1.
PE   2: Evidence at transcript level;
KW   Cytoplasm; Endosome; Membrane; Protein transport; Reference proteome;
KW   Transport.
FT   CHAIN           1..337
FT                   /note="Vacuolar protein sorting-associated protein 26B-A"
FT                   /id="PRO_0000247094"
FT   REGION          313..337
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   337 AA;  39188 MW;  1837EFDBBD5C8650 CRC64;
     MSFFGFGPAA ELDIALTDGE SRRRAEHKTE DGKKEKYFLF YDGETVSGRV TVNLRNPGKR
     LEHQGLKIEF IGQIELYYDR GNHHEFVSLV KDLARPGEIS QSQSFDFEFT HVEKPYESYT
     GQNVKLRYFL RATLSRRLND VVKEMDIVVH TLSTYPELNS SIKMEVGIED CLHIEFEYNK
     SKYHLKDVIV GKIYFLLVRI KIKHMEIDII KRETTGTGPN VYHENDTIAK YEIMDGAPVR
     GESIPIRLFL AGYELTPTMR DINKKFSVRY YLNLVLIDEE ERRYFKQQEI VLWRKGDIVR
     KSMSHQAAIA SQRFEGTSHP ETRPQHSGAA AVEQEHE