V26BB_XENLA
ID V26BB_XENLA Reviewed; 337 AA.
AC Q6DFB9;
DT 25-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 16-AUG-2004, sequence version 1.
DT 03-AUG-2022, entry version 66.
DE RecName: Full=Vacuolar protein sorting-associated protein 26B-B;
DE AltName: Full=Vesicle protein sorting 26B-B;
GN Name=vps26b-b;
OS Xenopus laevis (African clawed frog).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Amphibia;
OC Batrachia; Anura; Pipoidea; Pipidae; Xenopodinae; Xenopus; Xenopus.
OX NCBI_TaxID=8355;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC TISSUE=Oocyte;
RG NIH - Xenopus Gene Collection (XGC) project;
RL Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Acts as component of the retromer cargo-selective complex
CC (CSC). The CSC is believed to be the core functional component of
CC retromer or respective retromer complex variants acting to prevent
CC missorting of selected transmembrane cargo proteins into the lysosomal
CC degradation pathway. Retromer mediates retrograde transport of cargo
CC proteins from endosomes to the trans-Golgi network (TGN) (By
CC similarity). {ECO:0000250|UniProtKB:Q8C0E2}.
CC -!- SUBUNIT: Component of the heterotrimeric retromer cargo-selective
CC complex (CSC) which is believed to associate with variable sorting
CC nexins to form functionally distinct retromer complex variants (By
CC similarity). {ECO:0000250|UniProtKB:Q8C0E2}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000250|UniProtKB:Q8C0E2}.
CC Membrane; Peripheral membrane protein {ECO:0000250|UniProtKB:Q8C0E2}.
CC Endosome {ECO:0000250|UniProtKB:Q8C0E2}.
CC -!- SIMILARITY: Belongs to the VPS26 family. {ECO:0000305}.
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DR EMBL; BC076820; AAH76820.1; -; mRNA.
DR RefSeq; NP_001086570.1; NM_001093101.1.
DR AlphaFoldDB; Q6DFB9; -.
DR SMR; Q6DFB9; -.
DR DNASU; 446405; -.
DR GeneID; 446405; -.
DR KEGG; xla:446405; -.
DR CTD; 446405; -.
DR Xenbase; XB-GENE-945599; vps26b.S.
DR OMA; HSQENIA; -.
DR OrthoDB; 987411at2759; -.
DR Proteomes; UP000186698; Chromosome 7S.
DR Bgee; 446405; Expressed in egg cell and 19 other tissues.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0006886; P:intracellular protein transport; IEA:InterPro.
DR Gene3D; 2.60.40.640; -; 2.
DR InterPro; IPR014752; Arrestin-like_C.
DR InterPro; IPR028934; Vps26-related.
DR PANTHER; PTHR12233; PTHR12233; 1.
DR Pfam; PF03643; Vps26; 1.
PE 2: Evidence at transcript level;
KW Cytoplasm; Endosome; Membrane; Protein transport; Reference proteome;
KW Transport.
FT CHAIN 1..337
FT /note="Vacuolar protein sorting-associated protein 26B-B"
FT /id="PRO_0000247095"
FT REGION 313..337
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 337 AA; 39202 MW; 0C9B921CC2FA0717 CRC64;
MSFFGFGPAA ELDIALTDGE SRRRVEHKTE DGKKEKYFLF YDGETVSGRV TVSLRNPGKR
LEHQGLKIEF IGQIELYYDR GNHHEFVSLV KDLARPGELS QSQSFDFEFT HVEKPYESYT
GQNVKLRYFL RATLSRRLND VAKEMDIVVY TLSTYPELNS SIKMEVGIED CLHIEFEYNK
SKYHLKDVIV GKIYFLLVRI KIKHMEIDII KRETTGTGPN VYHENDTIAK YEIMDGAPVR
GESIPIRLFL AGYELTPTMR DINKKFSVRY YLNLVLIDEE ERRYFKQQEI VLWRKGDIVR
KSMSHQAAIA SQRFEGTSHP ETRPQHSGAA ALEQEHE