V2R1_MOUSE
ID V2R1_MOUSE Reviewed; 912 AA.
AC O70410; Q0WXF6;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 01-AUG-1998, sequence version 1.
DT 25-MAY-2022, entry version 116.
DE RecName: Full=Vomeronasal type-2 receptor 1;
DE AltName: Full=Putative pheromone receptor V2R1;
DE AltName: Full=V2Rx;
DE Flags: Precursor;
GN Name=Vmn2r1;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Vomeronasal sensory neuron;
RX PubMed=9292726; DOI=10.1016/s0896-6273(00)80946-0;
RA Ryba N.J.P., Tirindelli R.;
RT "A new multigene family of putative pheromone receptors.";
RL Neuron 19:371-379(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Kannan S., Krishnan M.;
RT "Molecular cloning and characterisation of mouse V2Rx pheromone receptor.";
RL Submitted (AUG-2006) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP PARTIAL PROTEIN SEQUENCE, AND BINDING TO SEX PHEROMONE.
RA Kannan S.;
RL Submitted (MAY-2006) to UniProtKB.
RN [4]
RP TISSUE SPECIFICITY.
RX PubMed=11157070; DOI=10.1523/jneurosci.21-03-00843.2001;
RA Martini S., Silvotti L., Shirazi A., Ryba N.J.P., Tirindelli R.;
RT "Co-expression of putative pheromone receptors in the sensory neurons of
RT the vomeronasal organ.";
RL J. Neurosci. 21:843-848(2001).
CC -!- FUNCTION: Putative pheromone receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed at the sensory surface of the vomeronasal
CC organ. {ECO:0000269|PubMed:11157070}.
CC -!- MISCELLANEOUS: The variant protein sequence (Ref.3) is capable of
CC binding the sex pheromone, 2-octanamine (2-1, methyl heptyl) via aa 11-
CC 17.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000305}.
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DR EMBL; AF053986; AAC08413.1; -; mRNA.
DR EMBL; AB267725; BAF02665.1; -; mRNA.
DR CCDS; CCDS17384.1; -.
DR RefSeq; NP_064302.2; NM_019918.2.
DR AlphaFoldDB; O70410; -.
DR SMR; O70410; -.
DR STRING; 10090.ENSMUSP00000029406; -.
DR TCDB; 9.A.14.7.6; the g-protein-coupled receptor (gpcr) family.
DR GlyGen; O70410; 4 sites.
DR PhosphoSitePlus; O70410; -.
DR PaxDb; O70410; -.
DR PRIDE; O70410; -.
DR ProteomicsDB; 300109; -.
DR DNASU; 56544; -.
DR GeneID; 56544; -.
DR KEGG; mmu:56544; -.
DR CTD; 56544; -.
DR MGI; MGI:3645892; Vmn2r1.
DR eggNOG; KOG1056; Eukaryota.
DR InParanoid; O70410; -.
DR OrthoDB; 327938at2759; -.
DR PhylomeDB; O70410; -.
DR BioGRID-ORCS; 56544; 2 hits in 68 CRISPR screens.
DR ChiTaRS; Vmn2r1; mouse.
DR PRO; PR:O70410; -.
DR Proteomes; UP000000589; Unplaced.
DR RNAct; O70410; protein.
DR GO; GO:0005938; C:cell cortex; IDA:MGI.
DR GO; GO:0030425; C:dendrite; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0038022; F:G protein-coupled olfactory receptor activity; IMP:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0004984; F:olfactory receptor activity; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IMP:MGI.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR Gene3D; 2.10.50.30; -; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; PTHR24061; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00592; CASENSINGR.
DR PRINTS; PR00248; GPCRMGR.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Direct protein sequencing; G-protein coupled receptor;
KW Glycoprotein; Membrane; Pheromone response; Receptor; Reference proteome;
KW Signal; Transducer; Transmembrane; Transmembrane helix.
FT SIGNAL 1..21
FT /evidence="ECO:0000255"
FT CHAIN 22..912
FT /note="Vomeronasal type-2 receptor 1"
FT /id="PRO_0000246126"
FT TOPO_DOM 22..623
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 624..644
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 645..657
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 658..678
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 679..691
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 692..712
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 713..732
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 733..753
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 754..778
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 779..799
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 800..812
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 813..833
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 834..840
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 841..861
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 862..912
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 24
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 38
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 299
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 386
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 12..17
FT /note="FLAFLW -> AEAAEH (in Ref. 2; BAF02665 and 3)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 912 AA; 102349 MW; 2C54FAB6DFBFA48D CRC64;
MASRQISLAL GFLAFLWAVL GAQNKTEEVQ CRLMAKFNLS GYVDAKNHSL VIAGLFPIHS
RIIPVDEAIL EPVSPMCEGF NFRGFRWMKT MIHTIKEINE RKDILPNHTL GYQIFDSCYT
ISKAMESSLV FLTGQEEFKP NFRNSTGSTL AALVGSGGSS LSVAASRILG LYYMPQVGYT
SSCSILSDKF QFPSYLRVLP SDNLQSEAIV NLIKHFGWVW VGAIAADDDY GKYGVKTFKE
KMESANLCVA FSETIPKVYS NEKMQKAVKA VKTSTAKVIV LYTSDIDLSL FVLEMIHHNI
TDRTWIATEA WITSALIAKP EYFPYFGGTI GFATPRSVIP GLKEFLYDVH PNKDPNDVLT
IEFWQTAFNC TWPNSSVPYN VDHRVNMTGK EDRLYDMSDQ LCTGEEKLED LKNTYLDTSQ
LRITKQCKQA VYAIAHGLDH LSRCQEGQGP FGSNQQCAYI PTFDFWQLMY YMKEIKFKSH
EDKWVILDDN GDLKNGHYDV LNWHLDDEGE ISFVTVGRFN FRSTNFELVI PTNSTIFWNT
ESSRRPDSFC TQVCPPGTRK GIRQGQPICC FDCIPCADGY VSEKSGQREC DPCGEDDWSN
AGKSKCVPKL VEFLAYGEAL GFTLVILSIF GALVVLAVTV VYVIHRHTPL VKANDRELSF
LIQMSLVITV LSSLLFIGKP CNWSCMARQI TLALGFCLCL SSILGKTISL FFAYRISVSK
TRLISMHPIF RKLIVLVCVV GEIGVCAAYL VLEPPRMFKN IEIQNVKIIF ECNEGSVEFL
CSIFGFDVLR ALLCFLTTFV ARQLPDNYYE GKCITFGMLV FFIVWISFVP AYLSTKGKFK
VAVEIFAILA SSYGLLGCLF LPKCFIILLR PKRNTDETVG GRVPTVDRSI QLTSASVSSE
LNSTTVSTVL DE
