V2R26_MOUSE
ID V2R26_MOUSE Reviewed; 855 AA.
AC Q6TAC4; O70409;
DT 11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT 11-JUL-2006, sequence version 2.
DT 03-AUG-2022, entry version 124.
DE RecName: Full=Vomeronasal type-2 receptor 26;
DE AltName: Full=Putative pheromone receptor V2R1b;
DE AltName: Full=Vomeronasal type-2 receptor 1b;
DE Flags: Precursor;
GN Name=Vmn2r26; Synonyms=V2r1b;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Vomeronasal sensory neuron;
RX PubMed=9292726; DOI=10.1016/s0896-6273(00)80946-0;
RA Ryba N.J.P., Tirindelli R.;
RT "A new multigene family of putative pheromone receptors.";
RL Neuron 19:371-379(1997).
RN [2]
RP NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RX PubMed=12354396; DOI=10.1016/s0896-6273(02)00904-2;
RA Del Punta K., Puche A., Adams N.C., Rodriguez I., Mombaerts P.;
RT "A divergent pattern of sensory axonal projections is rendered convergent
RT by second-order neurons in the accessory olfactory bulb.";
RL Neuron 35:1057-1066(2002).
CC -!- FUNCTION: Putative pheromone receptor.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000305}; Multi-pass membrane
CC protein {ECO:0000305}.
CC -!- TISSUE SPECIFICITY: Expressed in the basal epithelium of the
CC vomeronasal organ. Located to vomeronasal sensory neurons that project
CC their axons to six to ten glomeruli that reside in globally conserved
CC areas within the caudal accessory olfactory bulb (AOB).
CC {ECO:0000269|PubMed:12354396}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000305}.
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DR EMBL; AF053985; AAC08412.1; -; mRNA.
DR EMBL; AY426342; AAR04436.1; -; mRNA.
DR CCDS; CCDS20515.1; -.
DR RefSeq; NP_064301.2; NM_019917.2.
DR AlphaFoldDB; Q6TAC4; -.
DR SMR; Q6TAC4; -.
DR STRING; 10090.ENSMUSP00000032238; -.
DR GlyGen; Q6TAC4; 2 sites.
DR PaxDb; Q6TAC4; -.
DR PRIDE; Q6TAC4; -.
DR ProteomicsDB; 297904; -.
DR DNASU; 56552; -.
DR Ensembl; ENSMUST00000032238; ENSMUSP00000032238; ENSMUSG00000096630.
DR GeneID; 56552; -.
DR KEGG; mmu:56552; -.
DR UCSC; uc009dqm.1; mouse.
DR CTD; 56552; -.
DR MGI; MGI:2678394; Vmn2r26.
DR VEuPathDB; HostDB:ENSMUSG00000096630; -.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT00940000163606; -.
DR HOGENOM; CLU_005389_5_1_1; -.
DR InParanoid; Q6TAC4; -.
DR OMA; RENKICT; -.
DR OrthoDB; 546292at2759; -.
DR PhylomeDB; Q6TAC4; -.
DR TreeFam; TF331269; -.
DR BioGRID-ORCS; 56552; 2 hits in 36 CRISPR screens.
DR PRO; PR:Q6TAC4; -.
DR Proteomes; UP000000589; Chromosome 6.
DR RNAct; Q6TAC4; protein.
DR Bgee; ENSMUSG00000096630; Expressed in white adipose tissue.
DR ExpressionAtlas; Q6TAC4; baseline and differential.
DR Genevisible; Q6TAC4; MM.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0038022; F:G protein-coupled olfactory receptor activity; IGI:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0030182; P:neuron differentiation; IGI:MGI.
DR GO; GO:0019236; P:response to pheromone; IEA:UniProtKB-KW.
DR Gene3D; 2.10.50.30; -; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR000068; GPCR_3_Ca_sens_rcpt-rel.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR004073; GPCR_3_vmron_rcpt_2.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24061; PTHR24061; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01535; VOMERONASL2R.
DR SUPFAM; SSF53822; SSF53822; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Membrane;
KW Pheromone response; Receptor; Reference proteome; Signal; Transducer;
KW Transmembrane; Transmembrane helix.
FT SIGNAL 1..22
FT /evidence="ECO:0000255"
FT CHAIN 23..855
FT /note="Vomeronasal type-2 receptor 26"
FT /id="PRO_0000246125"
FT TOPO_DOM 23..595
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 596..616
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 617..630
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 631..651
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 652..662
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 663..683
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 684..706
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 707..727
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 728..753
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 754..774
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 775..786
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 787..807
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 808..814
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 815..835
FT /note="Helical"
FT /evidence="ECO:0000255"
FT TOPO_DOM 836..855
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT CARBOHYD 101
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 295
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 46
FT /note="S -> P (in Ref. 1; AAC08412)"
FT /evidence="ECO:0000305"
FT CONFLICT 73..75
FT /note="ADL -> CGS (in Ref. 1; AAC08412)"
FT /evidence="ECO:0000305"
FT CONFLICT 447
FT /note="L -> Q (in Ref. 1; AAC08412)"
FT /evidence="ECO:0000305"
FT CONFLICT 450
FT /note="G -> A (in Ref. 1; AAC08412)"
FT /evidence="ECO:0000305"
FT CONFLICT 561
FT /note="D -> H (in Ref. 1; AAC08412)"
FT /evidence="ECO:0000305"
FT CONFLICT 584..585
FT /note="MV -> IL (in Ref. 1; AAC08412)"
FT /evidence="ECO:0000305"
FT CONFLICT 644
FT /note="S -> F (in Ref. 1; AAC08412)"
FT /evidence="ECO:0000305"
FT CONFLICT 648
FT /note="M -> I (in Ref. 1; AAC08412)"
FT /evidence="ECO:0000305"
FT CONFLICT 685
FT /note="M -> V (in Ref. 1; AAC08412)"
FT /evidence="ECO:0000305"
FT CONFLICT 844
FT /note="K -> R (in Ref. 2; AAR04436)"
FT /evidence="ECO:0000305"
SQ SEQUENCE 855 AA; 96200 MW; 3B8C566F6E3CD501 CRC64;
MKLLTAFSPL VVLILFQEQI SCYYLTKYAS SGYYQDADFV IGGLFSLRVT DGDTFISRSG
VEDTSHIAEY VFADLIKYYQ HILAMVFAIE KINKDPNILF NKSLGFFLFN VNFIEMKAAE
GSMALLSGES PPIPNYSCRP EKTDKLVAVI GGISTSISIQ ISRVLSLYNV PQISYAPFDQ
ILGTRVQLQS PYQFSMHTAA LYQGIVQLLL YFTWIWVGLV VPDDMRGELY LRDITKEMIS
HGICFAFAEK VTEYSSMDTV NWKHFMERLT LTPVIITVGD THSLLRIVYF VIFYNLSGNV
WITTSDWYIT TLPFEQNLIY THFGGGLSFS FHMDEILGFK DFLRSVQPRK YPHDIFIRHV
WSSLFGCPHY YQHRLWDLSQ CEPNGSLSTR PLHAWDMNTS PYSYKVYAAV YAIAQALHEE
LSLRVEGDSS NKCLLQAPLP WKLHPFLQKG QLGRSTNEEN TVNKEVSAIK LDIFNYQSLQ
SGTEAHVKVG EFVFDSHSVQ HLSLNDKIIT WGKHRSQTPL SVCSQSCPFG FSKTAVEGKP
FCCFDCVPCP DGEIANKTDM DQCIKCPEDQ YPNKQRNQCL PKIMVFLAHE DPLGTVLVSL
AISLSAFSAM ILGLFICYRE TPIVRANNRN LSYLLLISLK LCFSCSLMFI GQPRTVTCVL
RQIIFGIVFS IVISAILAKT FIVVMAFKAI KPGSILKMGM VTRLSNAIVC CGSIIQVCIC
AVWLGTYPPF PDVDMHSEFG QIILWCNEGS TLAFYCVLGY LGFLASLSLL IAFLARRLPD
SFNEAKTITF SMLVFCSVWI SFVPAYLSSK GKTMVAVEIL SILASSAGLL GCIFLPKCYV
ILLKSGGHSR KKFFK
