V2R_BOVIN
ID V2R_BOVIN Reviewed; 370 AA.
AC P48044;
DT 01-FEB-1996, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1996, sequence version 1.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Vasopressin V2 receptor;
DE Short=V2R;
DE AltName: Full=AVPR V2;
DE AltName: Full=Antidiuretic hormone receptor;
DE AltName: Full=Renal-type arginine vasopressin receptor;
GN Name=AVPR2;
OS Bos taurus (Bovine).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Ruminantia; Pecora; Bovidae;
OC Bovinae; Bos.
OX NCBI_TaxID=9913;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC TISSUE=Kidney;
RX PubMed=7698346; DOI=10.1016/0014-5793(95)00150-8;
RA Ufer E., Postina R., Gorbulev V., Fahrenholz F.;
RT "An extracellular residue determines the agonist specificity of V2
RT vasopressin receptors.";
RL FEBS Lett. 362:19-23(1995).
RN [2]
RP PROTEIN SEQUENCE OF 110-126, AGONIST-BINDING SITE, FUNCTION, AND
RP SUBCELLULAR LOCATION.
RC TISSUE=Kidney;
RX PubMed=8257689; DOI=10.1021/bi00212a020;
RA Kojro E., Eich P., Gimpl G., Fahrenholz F.;
RT "Direct identification of an extracellular agonist binding site in the
RT renal V2 vasopressin receptor.";
RL Biochemistry 32:13537-13544(1993).
CC -!- FUNCTION: Receptor for arginine vasopressin (PubMed:7698346,
CC PubMed:8257689). The activity of this receptor is mediated by G
CC proteins which activate adenylate cyclase. Involved in renal water
CC reabsorption (By similarity). {ECO:0000250|UniProtKB:P30518,
CC ECO:0000269|PubMed:7698346, ECO:0000269|PubMed:8257689}.
CC -!- SUBUNIT: Interacts with ARRDC4 (By similarity). Identified in a complex
CC containing at least ARRDC4, V2R and HGS (By similarity). Interacts with
CC TMEM147 (By similarity). {ECO:0000250|UniProtKB:P30518}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:7698346,
CC ECO:0000269|PubMed:8257689}; Multi-pass membrane protein
CC {ECO:0000250|UniProtKB:P30518}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
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DR EMBL; X83741; CAA58709.1; -; mRNA.
DR PIR; S68777; S68777.
DR RefSeq; NP_776671.1; NM_174246.2.
DR AlphaFoldDB; P48044; -.
DR SMR; P48044; -.
DR STRING; 9913.ENSBTAP00000055744; -.
DR BindingDB; P48044; -.
DR ChEMBL; CHEMBL2344; -.
DR DrugCentral; P48044; -.
DR PaxDb; P48044; -.
DR Ensembl; ENSBTAT00000065044; ENSBTAP00000055744; ENSBTAG00000047138.
DR GeneID; 281642; -.
DR KEGG; bta:281642; -.
DR CTD; 554; -.
DR VEuPathDB; HostDB:ENSBTAG00000047138; -.
DR VGNC; VGNC:26360; AVPR2.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244882; -.
DR HOGENOM; CLU_009579_15_3_1; -.
DR InParanoid; P48044; -.
DR OMA; YVFCWAP; -.
DR OrthoDB; 890925at2759; -.
DR TreeFam; TF106499; -.
DR Reactome; R-BTA-388479; Vasopressin-like receptors.
DR Reactome; R-BTA-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR Reactome; R-BTA-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR PRO; PR:P48044; -.
DR Proteomes; UP000009136; Chromosome X.
DR Bgee; ENSBTAG00000047138; Expressed in mammary gland fat and 54 other tissues.
DR ExpressionAtlas; P48044; baseline and differential.
DR GO; GO:0030139; C:endocytic vesicle; IEA:Ensembl.
DR GO; GO:0005768; C:endosome; IEA:Ensembl.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; IEA:Ensembl.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0005000; F:vasopressin receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IEA:Ensembl.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; IEA:Ensembl.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IBA:GO_Central.
DR GO; GO:0034097; P:response to cytokine; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR InterPro; IPR000161; Vprsn_rcpt_V2.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PRINTS; PR00898; VASOPRSNV2R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW Cell membrane; Direct protein sequencing; G-protein coupled receptor;
KW Glycoprotein; Lipoprotein; Membrane; Palmitate; Receptor;
KW Reference proteome; Transducer; Transmembrane; Transmembrane helix.
FT CHAIN 1..370
FT /note="Vasopressin V2 receptor"
FT /id="PRO_0000070206"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..135
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..292
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..307
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..327
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..370
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..23
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 354..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT SITE 102
FT /note="Implicated in agonist binding"
FT SITE 106
FT /note="Implicated in agonist binding"
FT LIPID 340
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 341
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 22
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 370 AA; 40236 MW; 5FDCCC2CD21DD4AE CRC64;
MFMASTTSAV PWHLSQPTPA GNGSEGELLT ARDPLLAQAE LALLSTVFVA VALSNGLVLG
ALVRRGRRGR WAPMHVFIGH LCLADLAVAL FQVLPQLAWD ATDRFRGPDA LCRAVKYLQM
VGMYASSYMI LAMTLDRHRA ICRPMLAHRH GGGTHWNRPV LLAWAFSLLF SLPQLFIFAQ
RDVDGSGVLD CWARFAEPWG LRAYVTWIAL MVFVAPALGI AACQVLIFRE IHASLGPGPV
PRAGGPRRGC RPGSPAEGAR VSAAVAKTVK MTLVIVIVYV LCWAPFFLVQ LWAAWDPEAP
REGPPFVLLM LLASLNSCTN PWIYASFSSS ISSELRSLLC CTWRRAPPSP GPQEESCATA
SSFLAKDTPS
