V2R_CANLF
ID V2R_CANLF Reviewed; 370 AA.
AC O77808;
DT 11-JUL-2002, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 131.
DE RecName: Full=Vasopressin V2 receptor;
DE Short=V2R;
DE AltName: Full=AVPR V2;
DE AltName: Full=Antidiuretic hormone receptor;
DE AltName: Full=Renal-type arginine vasopressin receptor;
GN Name=AVPR2; Synonyms=V2R;
OS Canis lupus familiaris (Dog) (Canis familiaris).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Carnivora; Caniformia; Canidae; Canis.
OX NCBI_TaxID=9615;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RA Weber B.I.L., Rascher W.;
RL Submitted (SEP-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA].
RA Weber B.I.L., Rascher W.;
RT "Organization of the dog vasopressin receptor gene.";
RL Submitted (APR-1999) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC receptor is mediated by G proteins which activate adenylate cyclase.
CC Involved in renal water reabsorption (By similarity).
CC {ECO:0000250|UniProtKB:P30518}.
CC -!- SUBUNIT: Interacts with ARRDC4 (By similarity). Identified in a complex
CC containing at least ARRDC4, V2R and HGS (By similarity). Interacts with
CC TMEM147 (By similarity). {ECO:0000250|UniProtKB:P30518}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P30518};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:P30518}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
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DR EMBL; Y18136; CAA77063.1; -; mRNA.
DR EMBL; AJ238150; CAB41598.1; -; Genomic_DNA.
DR RefSeq; NP_001003177.1; NM_001003177.1.
DR RefSeq; XP_005641040.1; XM_005640983.2.
DR AlphaFoldDB; O77808; -.
DR SMR; O77808; -.
DR STRING; 9612.ENSCAFP00000028678; -.
DR PaxDb; O77808; -.
DR GeneID; 403804; -.
DR KEGG; cfa:403804; -.
DR CTD; 554; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_15_3_1; -.
DR InParanoid; O77808; -.
DR OMA; RIMMAEL; -.
DR OrthoDB; 890925at2759; -.
DR TreeFam; TF106499; -.
DR Proteomes; UP000002254; Unplaced.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0005000; F:vasopressin receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR InterPro; IPR000161; Vprsn_rcpt_V2.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PRINTS; PR00898; VASOPRSNV2R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Lipoprotein;
KW Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..370
FT /note="Vasopressin V2 receptor"
FT /id="PRO_0000070207"
FT TOPO_DOM 1..37
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..112
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..134
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..292
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..307
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..327
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..370
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..26
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..20
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 340
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 22
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 370 AA; 40200 MW; 8F4E133FAF800B5C CRC64;
MLLASTTSAV PRTLSPPTPA GNGSRELLDT RDPLLVQAEL ALLSTVFVAV ALSNGLVLGA
LARRVRRGRW APMHVFIGHL CLADLAVALF QVLPQLAWDA TDRFRGPDAL CRAVKYLQMV
GMYASSYMIL AMTLDRHRAI CRPMLAYRHG GGARWNRPVL VAWAFSLILS LPQLFIFAQR
DVGNGSGVLD CWAHFAEPWG LRAYVTWIAL MVFVAPALGI AACQVLIFRE IHSSLVPGPA
ERAGGCRGGH RTGSPSEGAR VSAAMAKTVR MTLVIVIVYV LCWAPFFLVQ LWAAWDPQAP
LEGAPFVLLM LLASLNSCTN PWIYAFFSSS VSSELRSLFC WARSRAPPSL GPQEESCATA
SSFLAKDTSS
