V2R_MOUSE
ID V2R_MOUSE Reviewed; 371 AA.
AC O88721;
DT 10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1998, sequence version 1.
DT 03-AUG-2022, entry version 153.
DE RecName: Full=Vasopressin V2 receptor;
DE Short=V2R;
DE AltName: Full=AVPR V2;
DE AltName: Full=Antidiuretic hormone receptor;
DE AltName: Full=Renal-type arginine vasopressin receptor;
GN Name=Avpr2; Synonyms=V2r;
OS Mus musculus (Mouse).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Mus; Mus.
OX NCBI_TaxID=10090;
RN [1]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=129/SvJ;
RA Guenther G., Eichhorst J., Krause G., Rosenthal W., Oksche A.;
RT "Structure and functional expression of the mouse vasopressin V2 receptor
RT gene.";
RL Submitted (JUN-1998) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE.
RA Platzer M., Brenner V., Reichwald K., Wiehe T., Oksche A., Rosenthal A.;
RT "Comparative sequence analysis of the mouse L1cam locus and the
RT corresponding region of human Xq28.";
RL Submitted (MAR-1999) to the EMBL/GenBank/DDBJ databases.
RN [3]
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=129/SvJ; TISSUE=Kidney;
RA Oksche A., Leder G., Rosenthal W.;
RT "Species differences in vasopressin V2 receptors: mRNA tissue distribution
RT and functional properties of the human and murine receptors.";
RL Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC receptor is mediated by G proteins which activate adenylate cyclase.
CC Involved in renal water reabsorption (By similarity).
CC {ECO:0000250|UniProtKB:P30518}.
CC -!- SUBUNIT: Interacts with ARRDC4 (By similarity). Identified in a complex
CC containing at least ARRDC4, V2R and HGS (By similarity). Interacts with
CC TMEM147 (By similarity). {ECO:0000250|UniProtKB:P30518}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250|UniProtKB:P30518};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:P30518}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
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DR EMBL; AJ006691; CAA07187.1; -; Genomic_DNA.
DR EMBL; AF133093; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AJ310753; CAC34589.1; -; mRNA.
DR CCDS; CCDS30216.1; -.
DR RefSeq; NP_062277.1; NM_019404.2.
DR RefSeq; XP_006527819.1; XM_006527756.3.
DR AlphaFoldDB; O88721; -.
DR SMR; O88721; -.
DR STRING; 10090.ENSMUSP00000033765; -.
DR GlyGen; O88721; 2 sites.
DR PhosphoSitePlus; O88721; -.
DR PaxDb; O88721; -.
DR PRIDE; O88721; -.
DR Antibodypedia; 17443; 310 antibodies from 32 providers.
DR DNASU; 12000; -.
DR Ensembl; ENSMUST00000033765; ENSMUSP00000033765; ENSMUSG00000031390.
DR GeneID; 12000; -.
DR KEGG; mmu:12000; -.
DR UCSC; uc009tmx.1; mouse.
DR CTD; 554; -.
DR MGI; MGI:88123; Avpr2.
DR VEuPathDB; HostDB:ENSMUSG00000031390; -.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244882; -.
DR HOGENOM; CLU_009579_15_3_1; -.
DR InParanoid; O88721; -.
DR OMA; RIMMAEL; -.
DR OrthoDB; 890925at2759; -.
DR PhylomeDB; O88721; -.
DR TreeFam; TF106499; -.
DR Reactome; R-MMU-388479; Vasopressin-like receptors.
DR Reactome; R-MMU-418555; G alpha (s) signalling events.
DR Reactome; R-MMU-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR Reactome; R-MMU-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-MMU-8856828; Clathrin-mediated endocytosis.
DR BioGRID-ORCS; 12000; 2 hits in 73 CRISPR screens.
DR PRO; PR:O88721; -.
DR Proteomes; UP000000589; Chromosome X.
DR RNAct; O88721; protein.
DR Bgee; ENSMUSG00000031390; Expressed in right kidney and 42 other tissues.
DR ExpressionAtlas; O88721; baseline and differential.
DR Genevisible; O88721; MM.
DR GO; GO:0030139; C:endocytic vesicle; ISO:MGI.
DR GO; GO:0005768; C:endosome; ISO:MGI.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:MGI.
DR GO; GO:0005886; C:plasma membrane; ISO:MGI.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0005000; F:vasopressin receptor activity; ISO:MGI.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; IMP:MGI.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0035814; P:negative regulation of renal sodium excretion; ISO:MGI.
DR GO; GO:0035811; P:negative regulation of urine volume; ISO:MGI.
DR GO; GO:0045777; P:positive regulation of blood pressure; ISO:MGI.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; ISO:MGI.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0003084; P:positive regulation of systemic arterial blood pressure; ISO:MGI.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IBA:GO_Central.
DR GO; GO:0034097; P:response to cytokine; IMP:MGI.
DR GO; GO:0021537; P:telencephalon development; IEA:Ensembl.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR InterPro; IPR000161; Vprsn_rcpt_V2.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PRINTS; PR00898; VASOPRSNV2R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Lipoprotein;
KW Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..371
FT /note="Vasopressin V2 receptor"
FT /id="PRO_0000070209"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..135
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..200
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..293
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..308
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..328
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 329..371
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..27
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 240..259
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..25
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 341
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 342
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 22
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 371 AA; 40645 MW; F2E7CBEA1113FD5E CRC64;
MILVSTTSAV PGALSSPSSP SNSSQEELLD DRDPLLVRAE LALLSTIFVA VALSNGLVLG
ALIRRGRRGR WAPMHVFISH LCLADLAVAL FQVLPQLAWD ATDRFHGPDA LCRAVKYLQM
VGMYASSYMI LAMTLDRHRA ICRPMLAYRH GGGARWNRPV LVAWAFSLLL SLPQLFIFAQ
RDVGNGSGVF DCWARFAEPW GLRAYVTWIA LMVFVAPALG IAACQVLIFR EIHASLVPGP
SERAGRRRRG HRTGSPSEGA HVSAAMAKTV RMTLVIVIVY VLCWAPFFLV QLWAAWDPEA
PLERPPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCAQRHTTHS LGPQDESCAT
ASSSLMKDTP S
