V2R_PIG
ID V2R_PIG Reviewed; 370 AA.
AC P32307;
DT 01-OCT-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-OCT-1993, sequence version 1.
DT 03-AUG-2022, entry version 130.
DE RecName: Full=Vasopressin V2 receptor;
DE Short=V2R;
DE AltName: Full=AVPR V2;
DE AltName: Full=Antidiuretic hormone receptor;
DE AltName: Full=Renal-type arginine vasopressin receptor;
GN Name=AVPR2;
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC TISSUE=Kidney;
RX PubMed=8393786; DOI=10.1111/j.1432-1033.1993.tb18000.x;
RA Gorbulev V., Buechner H., Akhundova A., Fahrenholz F.;
RT "Molecular cloning and functional characterization of V2 [8-lysine]
RT vasopressin and oxytocin receptors from a pig kidney cell line.";
RL Eur. J. Biochem. 215:1-7(1993).
CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC receptor is mediated by G proteins which activate adenylate cyclase
CC (PubMed:8393786). Involved in renal water reabsorption (By similarity).
CC {ECO:0000250|UniProtKB:P30518, ECO:0000269|PubMed:8393786}.
CC -!- SUBUNIT: Interacts with ARRDC4 (By similarity). Identified in a complex
CC containing at least ARRDC4, V2R and HGS (By similarity). Interacts with
CC TMEM147 (By similarity). {ECO:0000250|UniProtKB:P30518}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:8393786};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:P30518}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
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DR EMBL; X71795; CAA50678.1; -; mRNA.
DR PIR; S34042; S34042.
DR RefSeq; NP_999397.1; NM_214232.1.
DR AlphaFoldDB; P32307; -.
DR SMR; P32307; -.
DR STRING; 9823.ENSSSCP00000013598; -.
DR BindingDB; P32307; -.
DR ChEMBL; CHEMBL3944; -.
DR DrugCentral; P32307; -.
DR PaxDb; P32307; -.
DR PRIDE; P32307; -.
DR GeneID; 397462; -.
DR KEGG; ssc:397462; -.
DR CTD; 554; -.
DR eggNOG; KOG3656; Eukaryota.
DR HOGENOM; CLU_009579_15_3_1; -.
DR InParanoid; P32307; -.
DR TreeFam; TF106499; -.
DR PRO; PR:P32307; -.
DR Proteomes; UP000008227; Unplaced.
DR Proteomes; UP000314985; Unplaced.
DR Genevisible; P32307; SS.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0005000; F:vasopressin receptor activity; IBA:GO_Central.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0010628; P:positive regulation of gene expression; ISS:UniProtKB.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IBA:GO_Central.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR InterPro; IPR000161; Vprsn_rcpt_V2.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PRINTS; PR00898; VASOPRSNV2R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; G-protein coupled receptor; Glycoprotein; Lipoprotein;
KW Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..370
FT /note="Vasopressin V2 receptor"
FT /id="PRO_0000070210"
FT TOPO_DOM 1..37
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 38..62
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 63..76
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 77..97
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 98..112
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 113..134
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 135..158
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 159..179
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 180..199
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 200..219
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 220..270
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 271..292
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 293..307
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 308..327
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 328..370
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 347..370
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 352..370
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 340
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 341
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 21
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
SQ SEQUENCE 370 AA; 40537 MW; 18079C128B689F2F CRC64;
MLRATTSAVP RALSWPAAPG NGSEREPLDD RDPLLARVEL ALLSTVFVAV ALSNGLVLGA
LVRRGRRGRW APMHVFIGHL CLADLAVALF QVLPQLAWDA TYRFRGPDAL CRAVKYLQMV
GMYASSYMIL AMTLDRHRAI CRPMLAYRHG GGARWNRPVL VAWAFSLLLS LPQLFIFAQR
DVGDGSGVLD CWASFAEPWG LRAYVTWIAL MVFVAPALGI AACQVLIFRE IHTSLVPGPA
ERAGGHRGGR RAGSPREGAR VSAAMAKTAR MTLVIVAVYV LCWAPFFLVQ LWSVWDPKAP
REGPPFVLLM LLASLNSCTN PWIYASFSSS ISSELRSLLC CPRRRTPPSL RPQEESCATA
SSFSARDTSS
