V2R_RAT
ID V2R_RAT Reviewed; 371 AA.
AC Q00788; Q53ZC4;
DT 01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT 01-FEB-1994, sequence version 2.
DT 03-AUG-2022, entry version 170.
DE RecName: Full=Vasopressin V2 receptor;
DE Short=V2R;
DE AltName: Full=AVPR V2;
DE AltName: Full=Antidiuretic hormone receptor;
DE AltName: Full=Renal-type arginine vasopressin receptor;
GN Name=Avpr2;
OS Rattus norvegicus (Rat).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC Murinae; Rattus.
OX NCBI_TaxID=10116;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC STRAIN=Wistar Kyoto; TISSUE=Kidney;
RX PubMed=1534150; DOI=10.1038/357336a0;
RA Lolait S.J., O'Carroll A.-M., McBride O.W., Konig M., Morel A.,
RA Brownstein M.J.;
RT "Cloning and characterization of a vasopressin V2 receptor and possible
RT link to nephrogenic diabetes insipidus.";
RL Nature 357:336-339(1992).
RN [2]
RP NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION TO 246-254.
RC STRAIN=Sprague-Dawley; TISSUE=Kidney;
RX PubMed=7708485; DOI=10.1007/bf02584033;
RA Firsov D., Mandon B., Morel A., Merot J., le Maout S., Bellanger A.C.,
RA de Rouffignac C., Elalouf J.-M., Buhler J.M.;
RT "Molecular analysis of vasopressin receptors in the rat nephron. Evidence
RT for alternative splicing of the V2 receptor.";
RL Pflugers Arch. 429:79-89(1994).
RN [3]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC STRAIN=Sprague-Dawley;
RA Terry R., Mullins D.;
RT "Rat vasopressin 2 receptor gene DNA sequence.";
RL Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC receptor is mediated by G proteins which activate adenylate cyclase
CC (PubMed:1534150). Involved in renal water reabsorption (By similarity).
CC {ECO:0000250|UniProtKB:P30518, ECO:0000269|PubMed:1534150}.
CC -!- SUBUNIT: Interacts with ARRDC4 (By similarity). Identified in a complex
CC containing at least ARRDC4, V2R and HGS (By similarity). Interacts with
CC TMEM147 (By similarity). {ECO:0000250|UniProtKB:P30518}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1534150};
CC Multi-pass membrane protein {ECO:0000250|UniProtKB:P30518}.
CC -!- TISSUE SPECIFICITY: Kidney.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC ProRule:PRU00521}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; Z11932; CAA77989.1; -; mRNA.
DR EMBL; Z22758; CAA80439.1; -; Genomic_DNA.
DR EMBL; AY338195; AAQ01565.1; -; mRNA.
DR PIR; S44045; S44045.
DR RefSeq; NP_062009.1; NM_019136.1.
DR RefSeq; XP_006229611.1; XM_006229549.3.
DR PDB; 2JX4; NMR; -; A=226-271.
DR PDBsum; 2JX4; -.
DR AlphaFoldDB; Q00788; -.
DR SMR; Q00788; -.
DR STRING; 10116.ENSRNOP00000053179; -.
DR BindingDB; Q00788; -.
DR ChEMBL; CHEMBL3766; -.
DR DrugCentral; Q00788; -.
DR GuidetoPHARMACOLOGY; 368; -.
DR GlyGen; Q00788; 2 sites.
DR PhosphoSitePlus; Q00788; -.
DR PaxDb; Q00788; -.
DR Ensembl; ENSRNOT00000091495; ENSRNOP00000071931; ENSRNOG00000059862.
DR GeneID; 25108; -.
DR KEGG; rno:25108; -.
DR CTD; 554; -.
DR RGD; 2186; Avpr2.
DR eggNOG; KOG3656; Eukaryota.
DR GeneTree; ENSGT01050000244882; -.
DR InParanoid; Q00788; -.
DR OMA; RIMMAEL; -.
DR OrthoDB; 890925at2759; -.
DR PhylomeDB; Q00788; -.
DR TreeFam; TF106499; -.
DR Reactome; R-RNO-388479; Vasopressin-like receptors.
DR Reactome; R-RNO-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR Reactome; R-RNO-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR Reactome; R-RNO-8856828; Clathrin-mediated endocytosis.
DR EvolutionaryTrace; Q00788; -.
DR PRO; PR:Q00788; -.
DR Proteomes; UP000002494; Chromosome X.
DR Bgee; ENSRNOG00000059862; Expressed in kidney and 8 other tissues.
DR ExpressionAtlas; Q00788; baseline and differential.
DR Genevisible; Q00788; RN.
DR GO; GO:0030139; C:endocytic vesicle; ISO:RGD.
DR GO; GO:0005768; C:endosome; ISO:RGD.
DR GO; GO:0016021; C:integral component of membrane; TAS:RGD.
DR GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR GO; GO:0017046; F:peptide hormone binding; TAS:RGD.
DR GO; GO:0005000; F:vasopressin receptor activity; ISO:RGD.
DR GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; ISO:RGD.
DR GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR GO; GO:0035814; P:negative regulation of renal sodium excretion; IMP:RGD.
DR GO; GO:0035811; P:negative regulation of urine volume; IMP:RGD.
DR GO; GO:0045777; P:positive regulation of blood pressure; IDA:RGD.
DR GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:RGD.
DR GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
DR GO; GO:0003084; P:positive regulation of systemic arterial blood pressure; IMP:RGD.
DR GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IBA:GO_Central.
DR GO; GO:0034097; P:response to cytokine; ISO:RGD.
DR GO; GO:0021537; P:telencephalon development; IEP:RGD.
DR InterPro; IPR000276; GPCR_Rhodpsn.
DR InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR InterPro; IPR001817; Vasoprsn_rcpt.
DR InterPro; IPR000161; Vprsn_rcpt_V2.
DR Pfam; PF00001; 7tm_1; 1.
DR PRINTS; PR00237; GPCRRHODOPSN.
DR PRINTS; PR00896; VASOPRESSINR.
DR PRINTS; PR00898; VASOPRSNV2R.
DR PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE 1: Evidence at protein level;
KW 3D-structure; Cell membrane; G-protein coupled receptor; Glycoprotein;
KW Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW Transmembrane; Transmembrane helix.
FT CHAIN 1..371
FT /note="Vasopressin V2 receptor"
FT /id="PRO_0000070211"
FT TOPO_DOM 1..38
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 39..63
FT /note="Helical; Name=1"
FT /evidence="ECO:0000255"
FT TOPO_DOM 64..77
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 78..98
FT /note="Helical; Name=2"
FT /evidence="ECO:0000255"
FT TOPO_DOM 99..113
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 114..135
FT /note="Helical; Name=3"
FT /evidence="ECO:0000255"
FT TOPO_DOM 136..159
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 160..180
FT /note="Helical; Name=4"
FT /evidence="ECO:0000255"
FT TOPO_DOM 181..200
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 201..220
FT /note="Helical; Name=5"
FT /evidence="ECO:0000255"
FT TOPO_DOM 221..271
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 272..293
FT /note="Helical; Name=6"
FT /evidence="ECO:0000255"
FT TOPO_DOM 294..308
FT /note="Extracellular"
FT /evidence="ECO:0000255"
FT TRANSMEM 309..328
FT /note="Helical; Name=7"
FT /evidence="ECO:0000255"
FT TOPO_DOM 329..371
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT REGION 240..260
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 349..371
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT LIPID 341
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT LIPID 342
FT /note="S-palmitoyl cysteine"
FT /evidence="ECO:0000250"
FT CARBOHYD 22
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CARBOHYD 185
FT /note="N-linked (GlcNAc...) asparagine"
FT /evidence="ECO:0000255"
FT CONFLICT 246..254
FT /note="RRRRGRRTG -> TPQRAPDR (in Ref. 1; CAA77989)"
FT /evidence="ECO:0000305"
FT HELIX 226..236
FT /evidence="ECO:0007829|PDB:2JX4"
FT HELIX 238..242
FT /evidence="ECO:0007829|PDB:2JX4"
FT TURN 243..247
FT /evidence="ECO:0007829|PDB:2JX4"
FT TURN 251..253
FT /evidence="ECO:0007829|PDB:2JX4"
FT HELIX 254..273
FT /evidence="ECO:0007829|PDB:2JX4"
SQ SEQUENCE 371 AA; 40749 MW; 480636F298087D3C CRC64;
MLLVSTVSAV PGLFSPPSSP SNSSQEELLD DRDPLLVRAE LALLSTIFVA VALSNGLVLG
ALIRRGRRGR WAPMHVFISH LCLADLAVAL FQVLPQLAWD ATDRFHGPDA LCRAVKYLQM
VGMYASSYMI LAMTLDRHRA ICRPMLAYRH GGGARWNRPV LVAWAFSLLL SLPQLFIFAQ
RDVGNGSGVF DCWARFAEPW GLRAYVTWIA LMVFVAPALG IAACQVLIFR EIHASLVPGP
SERAGRRRRG RRTGSPSEGA HVSAAMAKTV RMTLVIVIVY VLCWAPFFLV QLWAAWDPEA
PLERPPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCAQRHTTHS LGPQDESCAT
ASSSLMKDTP S