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V2R_RAT
ID   V2R_RAT                 Reviewed;         371 AA.
AC   Q00788; Q53ZC4;
DT   01-APR-1993, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 2.
DT   03-AUG-2022, entry version 170.
DE   RecName: Full=Vasopressin V2 receptor;
DE            Short=V2R;
DE   AltName: Full=AVPR V2;
DE   AltName: Full=Antidiuretic hormone receptor;
DE   AltName: Full=Renal-type arginine vasopressin receptor;
GN   Name=Avpr2;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, AND SUBCELLULAR LOCATION.
RC   STRAIN=Wistar Kyoto; TISSUE=Kidney;
RX   PubMed=1534150; DOI=10.1038/357336a0;
RA   Lolait S.J., O'Carroll A.-M., McBride O.W., Konig M., Morel A.,
RA   Brownstein M.J.;
RT   "Cloning and characterization of a vasopressin V2 receptor and possible
RT   link to nephrogenic diabetes insipidus.";
RL   Nature 357:336-339(1992).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [GENOMIC DNA], AND SEQUENCE REVISION TO 246-254.
RC   STRAIN=Sprague-Dawley; TISSUE=Kidney;
RX   PubMed=7708485; DOI=10.1007/bf02584033;
RA   Firsov D., Mandon B., Morel A., Merot J., le Maout S., Bellanger A.C.,
RA   de Rouffignac C., Elalouf J.-M., Buhler J.M.;
RT   "Molecular analysis of vasopressin receptors in the rat nephron. Evidence
RT   for alternative splicing of the V2 receptor.";
RL   Pflugers Arch. 429:79-89(1994).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RA   Terry R., Mullins D.;
RT   "Rat vasopressin 2 receptor gene DNA sequence.";
RL   Submitted (JUL-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Receptor for arginine vasopressin. The activity of this
CC       receptor is mediated by G proteins which activate adenylate cyclase
CC       (PubMed:1534150). Involved in renal water reabsorption (By similarity).
CC       {ECO:0000250|UniProtKB:P30518, ECO:0000269|PubMed:1534150}.
CC   -!- SUBUNIT: Interacts with ARRDC4 (By similarity). Identified in a complex
CC       containing at least ARRDC4, V2R and HGS (By similarity). Interacts with
CC       TMEM147 (By similarity). {ECO:0000250|UniProtKB:P30518}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:1534150};
CC       Multi-pass membrane protein {ECO:0000250|UniProtKB:P30518}.
CC   -!- TISSUE SPECIFICITY: Kidney.
CC   -!- SIMILARITY: Belongs to the G-protein coupled receptor 1 family.
CC       Vasopressin/oxytocin receptor subfamily. {ECO:0000255|PROSITE-
CC       ProRule:PRU00521}.
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DR   EMBL; Z11932; CAA77989.1; -; mRNA.
DR   EMBL; Z22758; CAA80439.1; -; Genomic_DNA.
DR   EMBL; AY338195; AAQ01565.1; -; mRNA.
DR   PIR; S44045; S44045.
DR   RefSeq; NP_062009.1; NM_019136.1.
DR   RefSeq; XP_006229611.1; XM_006229549.3.
DR   PDB; 2JX4; NMR; -; A=226-271.
DR   PDBsum; 2JX4; -.
DR   AlphaFoldDB; Q00788; -.
DR   SMR; Q00788; -.
DR   STRING; 10116.ENSRNOP00000053179; -.
DR   BindingDB; Q00788; -.
DR   ChEMBL; CHEMBL3766; -.
DR   DrugCentral; Q00788; -.
DR   GuidetoPHARMACOLOGY; 368; -.
DR   GlyGen; Q00788; 2 sites.
DR   PhosphoSitePlus; Q00788; -.
DR   PaxDb; Q00788; -.
DR   Ensembl; ENSRNOT00000091495; ENSRNOP00000071931; ENSRNOG00000059862.
DR   GeneID; 25108; -.
DR   KEGG; rno:25108; -.
DR   CTD; 554; -.
DR   RGD; 2186; Avpr2.
DR   eggNOG; KOG3656; Eukaryota.
DR   GeneTree; ENSGT01050000244882; -.
DR   InParanoid; Q00788; -.
DR   OMA; RIMMAEL; -.
DR   OrthoDB; 890925at2759; -.
DR   PhylomeDB; Q00788; -.
DR   TreeFam; TF106499; -.
DR   Reactome; R-RNO-388479; Vasopressin-like receptors.
DR   Reactome; R-RNO-432040; Vasopressin regulates renal water homeostasis via Aquaporins.
DR   Reactome; R-RNO-8856825; Cargo recognition for clathrin-mediated endocytosis.
DR   Reactome; R-RNO-8856828; Clathrin-mediated endocytosis.
DR   EvolutionaryTrace; Q00788; -.
DR   PRO; PR:Q00788; -.
DR   Proteomes; UP000002494; Chromosome X.
DR   Bgee; ENSRNOG00000059862; Expressed in kidney and 8 other tissues.
DR   ExpressionAtlas; Q00788; baseline and differential.
DR   Genevisible; Q00788; RN.
DR   GO; GO:0030139; C:endocytic vesicle; ISO:RGD.
DR   GO; GO:0005768; C:endosome; ISO:RGD.
DR   GO; GO:0016021; C:integral component of membrane; TAS:RGD.
DR   GO; GO:0005887; C:integral component of plasma membrane; IBA:GO_Central.
DR   GO; GO:0048471; C:perinuclear region of cytoplasm; ISO:RGD.
DR   GO; GO:0005886; C:plasma membrane; ISO:RGD.
DR   GO; GO:0004930; F:G protein-coupled receptor activity; IBA:GO_Central.
DR   GO; GO:0042277; F:peptide binding; IBA:GO_Central.
DR   GO; GO:0017046; F:peptide hormone binding; TAS:RGD.
DR   GO; GO:0005000; F:vasopressin receptor activity; ISO:RGD.
DR   GO; GO:0007186; P:G protein-coupled receptor signaling pathway; IBA:GO_Central.
DR   GO; GO:0007249; P:I-kappaB kinase/NF-kappaB signaling; ISO:RGD.
DR   GO; GO:0008285; P:negative regulation of cell population proliferation; ISO:RGD.
DR   GO; GO:0035814; P:negative regulation of renal sodium excretion; IMP:RGD.
DR   GO; GO:0035811; P:negative regulation of urine volume; IMP:RGD.
DR   GO; GO:0045777; P:positive regulation of blood pressure; IDA:RGD.
DR   GO; GO:0008284; P:positive regulation of cell population proliferation; IMP:RGD.
DR   GO; GO:0010628; P:positive regulation of gene expression; IMP:UniProtKB.
DR   GO; GO:0003084; P:positive regulation of systemic arterial blood pressure; IMP:RGD.
DR   GO; GO:0045907; P:positive regulation of vasoconstriction; IBA:GO_Central.
DR   GO; GO:0001992; P:regulation of systemic arterial blood pressure by vasopressin; IBA:GO_Central.
DR   GO; GO:0034097; P:response to cytokine; ISO:RGD.
DR   GO; GO:0021537; P:telencephalon development; IEP:RGD.
DR   InterPro; IPR000276; GPCR_Rhodpsn.
DR   InterPro; IPR017452; GPCR_Rhodpsn_7TM.
DR   InterPro; IPR001817; Vasoprsn_rcpt.
DR   InterPro; IPR000161; Vprsn_rcpt_V2.
DR   Pfam; PF00001; 7tm_1; 1.
DR   PRINTS; PR00237; GPCRRHODOPSN.
DR   PRINTS; PR00896; VASOPRESSINR.
DR   PRINTS; PR00898; VASOPRSNV2R.
DR   PROSITE; PS00237; G_PROTEIN_RECEP_F1_1; 1.
DR   PROSITE; PS50262; G_PROTEIN_RECEP_F1_2; 1.
PE   1: Evidence at protein level;
KW   3D-structure; Cell membrane; G-protein coupled receptor; Glycoprotein;
KW   Lipoprotein; Membrane; Palmitate; Receptor; Reference proteome; Transducer;
KW   Transmembrane; Transmembrane helix.
FT   CHAIN           1..371
FT                   /note="Vasopressin V2 receptor"
FT                   /id="PRO_0000070211"
FT   TOPO_DOM        1..38
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        39..63
FT                   /note="Helical; Name=1"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        64..77
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        78..98
FT                   /note="Helical; Name=2"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        99..113
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        114..135
FT                   /note="Helical; Name=3"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        136..159
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        160..180
FT                   /note="Helical; Name=4"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        181..200
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        201..220
FT                   /note="Helical; Name=5"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        221..271
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        272..293
FT                   /note="Helical; Name=6"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        294..308
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        309..328
FT                   /note="Helical; Name=7"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        329..371
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   REGION          240..260
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          349..371
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   LIPID           341
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   LIPID           342
FT                   /note="S-palmitoyl cysteine"
FT                   /evidence="ECO:0000250"
FT   CARBOHYD        22
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CARBOHYD        185
FT                   /note="N-linked (GlcNAc...) asparagine"
FT                   /evidence="ECO:0000255"
FT   CONFLICT        246..254
FT                   /note="RRRRGRRTG -> TPQRAPDR (in Ref. 1; CAA77989)"
FT                   /evidence="ECO:0000305"
FT   HELIX           226..236
FT                   /evidence="ECO:0007829|PDB:2JX4"
FT   HELIX           238..242
FT                   /evidence="ECO:0007829|PDB:2JX4"
FT   TURN            243..247
FT                   /evidence="ECO:0007829|PDB:2JX4"
FT   TURN            251..253
FT                   /evidence="ECO:0007829|PDB:2JX4"
FT   HELIX           254..273
FT                   /evidence="ECO:0007829|PDB:2JX4"
SQ   SEQUENCE   371 AA;  40749 MW;  480636F298087D3C CRC64;
     MLLVSTVSAV PGLFSPPSSP SNSSQEELLD DRDPLLVRAE LALLSTIFVA VALSNGLVLG
     ALIRRGRRGR WAPMHVFISH LCLADLAVAL FQVLPQLAWD ATDRFHGPDA LCRAVKYLQM
     VGMYASSYMI LAMTLDRHRA ICRPMLAYRH GGGARWNRPV LVAWAFSLLL SLPQLFIFAQ
     RDVGNGSGVF DCWARFAEPW GLRAYVTWIA LMVFVAPALG IAACQVLIFR EIHASLVPGP
     SERAGRRRRG RRTGSPSEGA HVSAAMAKTV RMTLVIVIVY VLCWAPFFLV QLWAAWDPEA
     PLERPPFVLL MLLASLNSCT NPWIYASFSS SVSSELRSLL CCAQRHTTHS LGPQDESCAT
     ASSSLMKDTP S
 
 
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