ID   VA3_SOLRI               Reviewed;         211 AA.
AC   P35779;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   15-JUL-1999, sequence version 2.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Venom allergen 3;
DE   AltName: Full=Allergen Sol r III;
DE   AltName: Full=Cysteine-rich venom protein;
DE            Short=CRVP;
DE   AltName: Full=Venom allergen III;
DE   AltName: Allergen=Sol r 3;
OS   Solenopsis richteri (Black imported fire ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Myrmicinae; Solenopsis.
OX   NCBI_TaxID=30203;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   PubMed=9389299; DOI=10.1016/s0091-6749(97)70173-8;
RA   Hoffman D.R.;
RT   "Reactions to less common species of fire ants.";
RL   J. Allergy Clin. Immunol. 100:679-683(1997).
RN   [2]
RP   PROTEIN SEQUENCE OF 1-20.
RC   TISSUE=Venom;
RX   PubMed=2355158; DOI=10.1016/0091-6749(90)90042-3;
RA   Hoffman D.R., Smith A.M., Schmidt M., Moffitt J.E., Guralnick M.;
RT   "Allergens in Hymenoptera venom. XXII. Comparison of venoms from two
RT   species of imported fire ants, Solenopsis invicta and richteri.";
RL   J. Allergy Clin. Immunol. 85:988-996(1990).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- ALLERGEN: Causes an allergic reaction in human. The most common cause
CC       of insect venom allergy in the southeastern United States is the
CC       imported fire ant.
CC   -!- SIMILARITY: Belongs to the CRISP family. {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   PIR; B58853; B58853.
DR   PIR; D60727; D60727.
DR   AlphaFoldDB; P35779; -.
DR   SMR; P35779; -.
DR   Allergome; 3487; Sol r 3.0101.
DR   Allergome; 636; Sol r 3.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR002413; V5_allergen-like.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00838; V5ALLERGEN.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   PROSITE; PS01009; CRISP_1; 1.
DR   PROSITE; PS01010; CRISP_2; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Secreted.
FT   CHAIN           1..211
FT                   /note="Venom allergen 3"
FT                   /id="PRO_0000211532"
FT   DOMAIN          47..195
FT                   /note="SCP"
FT   REGION          58..77
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   DISULFID        4..19
FT                   /evidence="ECO:0000250"
FT   DISULFID        9..103
FT                   /evidence="ECO:0000250"
FT   DISULFID        30..96
FT                   /evidence="ECO:0000250"
FT   DISULFID        176..193
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   211 AA;  23869 MW;  99683BBA72844E9B CRC64;
     TNYCNLQSCK RNNAIHTMCQ YTSPTPGPMC LEYSNVGFTD AEKDAIVNKH NELRQRVASG
     KEMRGTNGPQ PPAVKMPNLT WDPELATIAQ RWANQCTFEH DACRNVERFA VGQNIAATSS
     SGKNKSTLSD MILLWYNEVK DFDNRWISSF PSDGNILMHV GHYTQIVWAK TKKIGCGRIM
     FKEDNWNKHY LVCNYGPAGN VLGAQIYEIK K