ID   VA4_SOLGE               Reviewed;         137 AA.
AC   Q9NH75; Q9NH74;
DT   20-JUN-2001, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2000, sequence version 1.
DT   25-MAY-2022, entry version 61.
DE   RecName: Full=Venom allergen 4;
DE   AltName: Full=Venom allergen IV;
DE   AltName: Allergen=Sol g 4;
DE   Flags: Precursor;
OS   Solenopsis geminata (Tropical fire ant).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Myrmicinae; Solenopsis.
OX   NCBI_TaxID=121131;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Schmidt M., Hoffman D.R.;
RT   "Allergens from tropical fire ant venom.";
RL   Submitted (FEB-2000) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Monomer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- ALLERGEN: Causes an allergic reaction in human. The most common cause
CC       of insect venom allergy in the southeastern United States is the
CC       imported fire ant.
CC   -!- SIMILARITY: Belongs to the ant venom allergen 2/4 family.
CC       {ECO:0000305}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   EMBL; AF230383; AAF65312.1; -; mRNA.
DR   EMBL; AF230384; AAF65313.1; -; mRNA.
DR   AlphaFoldDB; Q9NH75; -.
DR   SMR; Q9NH75; -.
DR   Allergome; 3479; Sol g 4.0101.
DR   Allergome; 3480; Sol g 4.0201.
DR   Allergome; 629; Sol g 4.
DR   PRIDE; Q9NH75; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0005549; F:odorant binding; IEA:InterPro.
DR   Gene3D; 1.10.238.190; -; 1.
DR   InterPro; IPR038211; Ant_venon_allerg_soli_2/4_sf.
DR   InterPro; IPR036728; PBP_GOBP_sf.
DR   SUPFAM; SSF47565; SSF47565; 1.
PE   1: Evidence at protein level;
KW   Allergen; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000250"
FT   CHAIN           20..137
FT                   /note="Venom allergen 4"
FT                   /id="PRO_0000022647"
FT   VARIANT         28
FT                   /note="M -> V (in Sol g 4.02)"
FT   VARIANT         33
FT                   /note="E -> K (in Sol g 4.02)"
FT   VARIANT         123
FT                   /note="L -> R (in Sol g 4.02)"
SQ   SEQUENCE   137 AA;  15667 MW;  F888BF6D11CCA082 CRC64;
     MKTFVLVSCL LVFTQIIYAV DIKELKIMNR ILEKCIRTVP KGENDPINPL KNVNVLYCAF
     SKRGIFTPKG VNTKQYINYC EKTIINPADI KQCKKLISKC IKKVYDRPGP IIERSKNLLS
     CVLKKGVLEL TVYGKKK