ID   VA4_SOLIN               Reviewed;         137 AA.
AC   P35777; Q9UB98; Q9UB99;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   20-JUN-2001, sequence version 2.
DT   03-AUG-2022, entry version 82.
DE   RecName: Full=Venom allergen 4;
DE   AltName: Full=Allergen Sol i IV;
DE   AltName: Full=Venom allergen IV;
DE   AltName: Allergen=Sol i 4;
DE   Flags: Precursor;
OS   Solenopsis invicta (Red imported fire ant) (Solenopsis wagneri).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Formicoidea;
OC   Formicidae; Myrmicinae; Solenopsis.
OX   NCBI_TaxID=13686;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Schmidt M., Gridley B., Sakell R.H., Hoffman D.R.;
RL   Submitted (NOV-1998) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 20-137.
RC   TISSUE=Venom;
RX   PubMed=8423273; DOI=10.1016/0091-6749(93)90298-t;
RA   Hoffman D.R.;
RT   "Allergens in Hymenoptera venom XXIV: the amino acid sequences of imported
RT   fire ant venom allergens Sol i II, Sol i III, and Sol i IV.";
RL   J. Allergy Clin. Immunol. 91:71-78(1993).
RN   [3]
RP   PROTEIN SEQUENCE OF 20-50.
RC   TISSUE=Venom;
RX   PubMed=2355158; DOI=10.1016/0091-6749(90)90042-3;
RA   Hoffman D.R., Smith A.M., Schmidt M., Moffitt J.E., Guralnick M.;
RT   "Allergens in Hymenoptera venom. XXII. Comparison of venoms from two
RT   species of imported fire ants, Solenopsis invicta and richteri.";
RL   J. Allergy Clin. Immunol. 85:988-996(1990).
CC   -!- SUBUNIT: Monomer.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- ALLERGEN: Causes an allergic reaction in human. The most common cause
CC       of insect venom allergy in the southeastern United States is the
CC       imported fire ant.
CC   -!- SIMILARITY: Belongs to the ant venom allergen 2/4 family.
CC       {ECO:0000305}.
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DR   EMBL; AF103805; AAC97369.1; -; mRNA.
DR   EMBL; AF103806; AAC97370.1; -; mRNA.
DR   PIR; B44582; C37330.
DR   AlphaFoldDB; P35777; -.
DR   SMR; P35777; -.
DR   Allergome; 3484; Sol i 4.0101.
DR   Allergome; 633; Sol i 4.
DR   EnsemblMetazoa; XM_039454526.1; XP_039310460.1; LOC113002676.
DR   OrthoDB; 1634893at2759; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 1.10.238.190; -; 1.
DR   InterPro; IPR038211; Ant_venon_allerg_soli_2/4_sf.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Secreted; Signal.
FT   SIGNAL          1..19
FT                   /evidence="ECO:0000269|PubMed:2355158,
FT                   ECO:0000269|PubMed:8423273"
FT   CHAIN           20..137
FT                   /note="Venom allergen 4"
FT                   /id="PRO_0000022648"
FT   VARIANT         42
FT                   /note="R -> H"
FT   VARIANT         51
FT                   /note="R -> K (in Sol i 4.02)"
FT   VARIANT         56
FT                   /note="W -> I"
FT   VARIANT         56
FT                   /note="W -> L (in Sol i 4.02)"
FT   VARIANT         84
FT                   /note="A -> I (in Sol i 4.02)"
FT   VARIANT         111
FT                   /note="I -> V"
FT   CONFLICT        136..137
FT                   /note="KK -> N (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   137 AA;  15728 MW;  2F6E50BA26C57E89 CRC64;
     MKTFVLVSCL LVFTQIIYAL DIKEISIMNR ILEKCIRTVP KRENDPINPL RNVNVWYCAF
     TKRGIFTPKG VNTKQYINYC EKTAISPADI KLCKKIASKC VKKVYDRPGP IIERSKNLLS
     CVLKKGLLEL TVYGKKK