ID   VA52_POLPI              Reviewed;         206 AA.
AC   D4P2Y4; A0A1B1XXW6; C0HJV9;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-DEC-2018, sequence version 2.
DT   25-MAY-2022, entry version 29.
DE   RecName: Full=Venom allergen 5 2;
DE   AltName: Full=Antigen 5;
DE   AltName: Full=Cysteine-rich venom protein;
DE            Short=CRVP;
DE   AltName: Allergen=Poly p 5 {ECO:0000305};
OS   Polybia paulista (Neotropical social wasp) (Swarm-founding polistine wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Polistinae; Epiponini; Polybia.
OX   NCBI_TaxID=291283;
RN   [1] {ECO:0000312|EMBL:ANW82807.1}
RP   NUCLEOTIDE SEQUENCE [MRNA], AND TISSUE SPECIFICITY.
RC   TISSUE=Venom gland {ECO:0000303|PubMed:28837089};
RX   PubMed=28837089; DOI=10.3390/toxins9090259;
RA   Bazon M.L., Perez-Riverol A., Dos Santos-Pinto J.R.A., Fernandes L.G.R.,
RA   Lasa A.M., Justo-Jacomini D.L., Palma M.S., Zollner R.L.,
RA   Brochetto-Braga M.R.;
RT   "Heterologous Expression, Purification and Immunoreactivity of the Antigen
RT   5 from Polybia paulista Wasp Venom.";
RL   Toxins 9:259-259(2017).
RN   [2]
RP   PROTEIN SEQUENCE, SUBCELLULAR LOCATION, MASS SPECTROMETRY, ALLERGEN, AND
RP   IDENTIFICATION BY MASS SPECTROMETRY.
RC   TISSUE=Venom {ECO:0000303|Ref.2};
RA   Da Amicis K., Watanabe A., Castro F., Palma M., Kalil J., Ferreira F.,
RA   Briza P., Wohlschlager T., Gadermaier G., Santos K.S.;
RL   Submitted (SEP-2015) to UniProtKB.
RN   [3]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 18-158, AND TISSUE SPECIFICITY.
RC   TISSUE=Venom gland {ECO:0000303|Ref.3};
RA   Giratto D.T., Suemasu C.N., Jacomini D.L.J., Brochetto-Braga M.R.;
RT   "Cloning and heterologous expression of the antigen 5 venom Polybia
RT   paulista (Hymenopetra: Vespidae).";
RL   Submitted (JAN-2010) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|Ref.2}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:28837089, ECO:0000269|Ref.3}.
CC   -!- MASS SPECTROMETRY: Mass=23084; Method=MALDI;
CC       Evidence={ECO:0000269|Ref.2};
CC   -!- ALLERGEN: Causes an allergic reaction in human. {ECO:0000269|Ref.2}.
CC   -!- SIMILARITY: Belongs to the CRISP family. Venom allergen 5-like
CC       subfamily. {ECO:0000305}.
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DR   EMBL; KU558986; ANW82807.1; -; mRNA.
DR   EMBL; GU562619; ADD63684.1; -; mRNA.
DR   EMBL; GU573767; ADD64704.1; -; mRNA.
DR   AlphaFoldDB; D4P2Y4; -.
DR   SMR; D4P2Y4; -.
DR   Allergome; 11910; Poly p 5.0101.
DR   Allergome; 8738; Poly p 5.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR002413; V5_allergen-like.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00838; V5ALLERGEN.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   PROSITE; PS01009; CRISP_1; 1.
DR   PROSITE; PS01010; CRISP_2; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Secreted.
FT   CHAIN           1..206
FT                   /note="Venom allergen 5 2"
FT                   /evidence="ECO:0000269|Ref.2"
FT                   /id="PRO_0000401929"
FT   DOMAIN          48..191
FT                   /note="SCP"
FT                   /evidence="ECO:0000255"
FT   DISULFID        4..16
FT                   /evidence="ECO:0000250|UniProtKB:P10736"
FT   DISULFID        8..104
FT                   /evidence="ECO:0000250|UniProtKB:P10736"
FT   DISULFID        28..96
FT                   /evidence="ECO:0000250|UniProtKB:P10736"
FT   DISULFID        172..189
FT                   /evidence="ECO:0000250|UniProtKB:P10736"
SQ   SEQUENCE   206 AA;  23084 MW;  79402C4B4756E415 CRC64;
     NKYCNIKCSK VAHTVCQYGE STKPSSKCNK VSITSVGVTE EEKKLIVDEH NRFRQKVAQG
     LETRGNPGPQ PAASDMNNLV WNDELAYIAQ VWASQCQFFV HDKCRNTAQY QVGQNIAYSA
     STAAYPGIVS LIVLWENEVK DFNYSQGITK ENFSKVGHYT QVVWAKTKEV GCGSIKYIEK
     GMKSHYLVCN YGPAGNYMGQ PIYTKK