VA52_VESCR
ID VA52_VESCR Reviewed; 202 AA.
AC P35782;
DT 01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 1.
DT 25-MAY-2022, entry version 83.
DE RecName: Full=Venom allergen 5.02;
DE AltName: Full=Allergen Vesp c V.02;
DE AltName: Full=Antigen 5-2;
DE Short=Ag5-2;
DE AltName: Full=Cysteine-rich venom protein;
DE Short=CRVP;
DE AltName: Allergen=Vesp c 5.02;
OS Vespa crabro (European hornet).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC Vespidae; Vespinae; Vespa.
OX NCBI_TaxID=7445;
RN [1]
RP PROTEIN SEQUENCE.
RC TISSUE=Venom;
RX PubMed=8227862; DOI=10.1016/0091-6749(93)90014-7;
RA Hoffman D.R.;
RT "Allergens in Hymenoptera venom. XXV: the amino acid sequences of antigen 5
RT molecules and the structural basis of antigenic cross-reactivity.";
RL J. Allergy Clin. Immunol. 92:707-716(1993).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- ALLERGEN: Causes an allergic reaction in human.
CC -!- SIMILARITY: Belongs to the CRISP family. Venom allergen 5-like
CC subfamily. {ECO:0000305}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR PIR; H44583; H44583.
DR AlphaFoldDB; P35782; -.
DR SMR; P35782; -.
DR Allergome; 673; Vesp c 5.
DR Allergome; 766; Vesp c 5.0102.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.33.10; -; 1.
DR InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR InterPro; IPR014044; CAP_domain.
DR InterPro; IPR035940; CAP_sf.
DR InterPro; IPR001283; CRISP-related.
DR InterPro; IPR002413; V5_allergen-like.
DR PANTHER; PTHR10334; PTHR10334; 1.
DR Pfam; PF00188; CAP; 1.
DR PRINTS; PR00838; V5ALLERGEN.
DR PRINTS; PR00837; V5TPXLIKE.
DR SMART; SM00198; SCP; 1.
DR SUPFAM; SSF55797; SSF55797; 1.
DR PROSITE; PS01009; CRISP_1; 1.
DR PROSITE; PS01010; CRISP_2; 1.
PE 1: Evidence at protein level;
KW Allergen; Direct protein sequencing; Disulfide bond; Secreted.
FT CHAIN 1..202
FT /note="Venom allergen 5.02"
FT /id="PRO_0000211540"
FT DOMAIN 46..187
FT /note="SCP"
FT DISULFID 4..16
FT /evidence="ECO:0000250"
FT DISULFID 8..101
FT /evidence="ECO:0000250"
FT DISULFID 26..94
FT /evidence="ECO:0000250"
FT DISULFID 168..185
FT /evidence="ECO:0000250"
SQ SEQUENCE 202 AA; 22781 MW; B710E9198413F547 CRC64;
NNYCKIKCRS GIHTLCKYGT STKPNCGKNV VKASGLTKQE NLEILKQHNE FRQKVARGLE
TRGNPGPQPP AKSMNTLVWN DELAQIAQVW ANQCNYGHDN CRNSAKYSVG QNIAEGSTSA
DNFVNVSNMV KMWEDEVKDY QYGSPKNKLN KVGHYTQMVW AKTKEIGCGS EDYIEDGWHR
HYLVCNYGPA GNVGNEPIYE RK