VA53_DOLMA
ID VA53_DOLMA Reviewed; 215 AA.
AC P10737;
DT 01-JUL-1989, integrated into UniProtKB/Swiss-Prot.
DT 01-JUN-1994, sequence version 3.
DT 25-MAY-2022, entry version 92.
DE RecName: Full=Venom allergen 5.02;
DE AltName: Full=Allergen Dol m V-B;
DE AltName: Full=Antigen 5 form 3;
DE Short=Ag5-3;
DE AltName: Full=Cysteine-rich venom protein;
DE Short=CRVP;
DE AltName: Allergen=Dol m 5.02;
DE Flags: Precursor; Fragment;
OS Dolichovespula maculata (Bald-faced hornet) (Vespula maculata).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC Vespidae; Vespinae; Dolichovespula.
OX NCBI_TaxID=7441;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC TISSUE=Venom, and Venom gland;
RX PubMed=3422469; DOI=10.1073/pnas.85.3.895;
RA Fang K.S.Y., Vitale M., Fehlner P., King T.P.;
RT "cDNA cloning and primary structure of a white-face hornet venom allergen,
RT antigen 5.";
RL Proc. Natl. Acad. Sci. U.S.A. 85:895-899(1988).
RN [2]
RP PARTIAL PROTEIN SEQUENCE, AND DISULFIDE BONDS.
RC TISSUE=Venom;
RX PubMed=2402482;
RA King T.P., Moran D., Wang D.F., Kochoumian L., Chait B.T.;
RT "Structural studies of a hornet venom allergen antigen 5, Dol m V and its
RT sequence similarity with other proteins.";
RL Protein Seq. Data Anal. 3:263-266(1990).
CC -!- SUBCELLULAR LOCATION: Secreted.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC -!- ALLERGEN: Causes an allergic reaction in human.
CC -!- SIMILARITY: Belongs to the CRISP family. Venom allergen 5-like
CC subfamily. {ECO:0000305}.
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DR EMBL; J03602; AAA28302.1; ALT_TERM; mRNA.
DR PIR; B31085; B31085.
DR AlphaFoldDB; P10737; -.
DR SMR; P10737; -.
DR Allergome; 1657; Dol m 5.02.
DR Allergome; 330; Dol m 5.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR Gene3D; 3.40.33.10; -; 1.
DR InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR InterPro; IPR014044; CAP_domain.
DR InterPro; IPR035940; CAP_sf.
DR InterPro; IPR001283; CRISP-related.
DR InterPro; IPR002413; V5_allergen-like.
DR PANTHER; PTHR10334; PTHR10334; 1.
DR Pfam; PF00188; CAP; 1.
DR PRINTS; PR00838; V5ALLERGEN.
DR PRINTS; PR00837; V5TPXLIKE.
DR SMART; SM00198; SCP; 1.
DR SUPFAM; SSF55797; SSF55797; 1.
DR PROSITE; PS01009; CRISP_1; 1.
DR PROSITE; PS01010; CRISP_2; 1.
PE 1: Evidence at protein level;
KW Allergen; Direct protein sequencing; Disulfide bond; Secreted; Signal.
FT SIGNAL <1..10
FT CHAIN 11..215
FT /note="Venom allergen 5.02"
FT /id="PRO_0000006295"
FT DOMAIN 55..200
FT /note="SCP"
FT DISULFID 14..26
FT /evidence="ECO:0000269|PubMed:2402482"
FT DISULFID 18..111
FT /evidence="ECO:0000269|PubMed:2402482"
FT DISULFID 36..104
FT /evidence="ECO:0000269|PubMed:2402482"
FT DISULFID 181..198
FT /evidence="ECO:0000269|PubMed:2402482"
FT NON_TER 1
SQ SEQUENCE 215 AA; 24270 MW; D8FEEBE99CE9A0BA CRC64;
PIINLSFGEA NNYCKIKCSR GIHTLCKFGT SMKPNCGSKL VKVHGVSNDE KNEIVNRHNQ
FRQKVAKGLE TRGNPGPQPP AKNMNVLVWN DELAKIAQTW ANQCSFGHDQ CRNTEKYQVG
QNVAIASTTG NSYATMSKLI EMWENEVKDF NPKKGTMGDN NFSKVGHYTQ MVWGKTKEIG
CGSVKYIENN WHTHYLVCNY GPAGNYMDQP IYERK