VA576_SCODE
ID VA576_SCODE Reviewed; 210 AA.
AC P0DPU1;
DT 10-APR-2019, integrated into UniProtKB/Swiss-Prot.
DT 10-APR-2019, sequence version 1.
DT 25-MAY-2022, entry version 7.
DE RecName: Full=Scoloptoxin SSD976 {ECO:0000303|PubMed:23148443};
DE AltName: Full=Cysteine-rich venom protein {ECO:0000305};
DE Short=CRVP {ECO:0000305};
DE Flags: Precursor;
OS Scolopendra dehaani (Thai centipede) (Scolopendra subspinipes dehaani).
OC Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Myriapoda; Chilopoda;
OC Pleurostigmophora; Scolopendromorpha; Scolopendridae; Scolopendra.
OX NCBI_TaxID=2609776;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-50, SUBCELLULAR
RP LOCATION, MASS SPECTROMETRY, AND FUNCTION.
RC TISSUE=Venom, and Venom gland;
RX PubMed=23148443; DOI=10.1021/pr300881d;
RA Liu Z.C., Zhang R., Zhao F., Chen Z.M., Liu H.W., Wang Y.J., Jiang P.,
RA Zhang Y., Wu Y., Ding J.P., Lee W.H., Zhang Y.;
RT "Venomic and transcriptomic analysis of centipede Scolopendra subspinipes
RT dehaani.";
RL J. Proteome Res. 11:6197-6212(2012).
CC -!- FUNCTION: Voltage-gated calcium channel inhibitor.
CC {ECO:0000269|PubMed:23148443}.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:23148443}.
CC -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC {ECO:0000305|PubMed:23148443}.
CC -!- PTM: Contains 3 disulfide bonds. {ECO:0000305}.
CC -!- MASS SPECTROMETRY: Mass=20643.3; Method=MALDI;
CC Evidence={ECO:0000269|PubMed:23148443};
CC -!- SIMILARITY: Belongs to the CRISP family. Venom allergen 5-like
CC subfamily. {ECO:0000305}.
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DR EMBL; KC144967; -; NOT_ANNOTATED_CDS; mRNA.
DR AlphaFoldDB; P0DPU1; -.
DR SMR; P0DPU1; -.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005246; F:calcium channel regulator activity; IEA:UniProtKB-KW.
DR GO; GO:0090729; F:toxin activity; IEA:UniProtKB-KW.
DR Gene3D; 3.40.33.10; -; 1.
DR InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR InterPro; IPR014044; CAP_domain.
DR InterPro; IPR035940; CAP_sf.
DR InterPro; IPR001283; CRISP-related.
DR InterPro; IPR002413; V5_allergen-like.
DR PANTHER; PTHR10334; PTHR10334; 1.
DR Pfam; PF00188; CAP; 1.
DR PRINTS; PR00838; V5ALLERGEN.
DR PRINTS; PR00837; V5TPXLIKE.
DR SMART; SM00198; SCP; 1.
DR SUPFAM; SSF55797; SSF55797; 1.
DR PROSITE; PS01009; CRISP_1; 1.
DR PROSITE; PS01010; CRISP_2; 1.
PE 1: Evidence at protein level;
KW Calcium channel impairing toxin; Direct protein sequencing; Disulfide bond;
KW Ion channel impairing toxin; Secreted; Signal; Toxin;
KW Voltage-gated calcium channel impairing toxin.
FT SIGNAL 1..23
FT /evidence="ECO:0000269|PubMed:23148443"
FT CHAIN 24..210
FT /note="Scoloptoxin SSD976"
FT /evidence="ECO:0000269|PubMed:23148443"
FT /id="PRO_0000446849"
SQ SEQUENCE 210 AA; 23120 MW; 7E445587F82CCFDA CRC64;
MNILLSSTLF VLLMFQIIGS GMGCDMKVRG LDANMKKMIL DLHNKKRQIV ANGQQSGQPS
AANMKELHWN DEIAANAQRS AETCVFEHTA KSLRKTTKYS YLGENIYKGS YPDPIPRSVN
AWYDEVKDVT PAVVKSFSSG GPMIGHYTQM VWANTEALGC GLVTASDRNS YLFCQYGPGG
NYRSQPIYKQ GPPASDCKNG KSSKYPGLCN