ID   VA5_MICHY               Reviewed;         232 AA.
AC   A9YME1;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   05-FEB-2008, sequence version 1.
DT   25-MAY-2022, entry version 42.
DE   RecName: Full=Venom allergen 5;
DE   AltName: Full=Antigen 5;
DE   AltName: Full=Cysteine-rich venom protein;
DE            Short=CRVP;
DE   AltName: Full=Venom protein 3;
DE   Flags: Precursor;
OS   Microctonus hyperodae (Parasitoid wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Parasitoida;
OC   Ichneumonoidea; Braconidae; Euphorinae; Microctonus.
OX   NCBI_TaxID=165561;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RX   PubMed=18477245; DOI=10.1111/j.1365-2583.2008.00802.x;
RA   Crawford A.M., Brauning R., Smolenski G., Ferguson C., Barton D.,
RA   Wheeler T.T., McCulloch A.;
RT   "The constituents of Microctonus sp. parasitoid venoms.";
RL   Insect Mol. Biol. 17:313-324(2008).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- ALLERGEN: Causes an allergic reaction in human. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRISP family. Venom allergen 5-like
CC       subfamily. {ECO:0000305}.
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DR   EMBL; EU249354; ABY19390.1; -; mRNA.
DR   AlphaFoldDB; A9YME1; -.
DR   SMR; A9YME1; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR002413; V5_allergen-like.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00838; V5ALLERGEN.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   PROSITE; PS01009; CRISP_1; 1.
DR   PROSITE; PS01010; CRISP_2; 1.
PE   2: Evidence at transcript level;
KW   Allergen; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000255"
FT   CHAIN           24..232
FT                   /note="Venom allergen 5"
FT                   /id="PRO_0000401928"
FT   DOMAIN          71..217
FT                   /note="SCP"
FT   DISULFID        28..43
FT                   /evidence="ECO:0000250"
FT   DISULFID        54..119
FT                   /evidence="ECO:0000250"
FT   DISULFID        198..215
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   232 AA;  25765 MW;  3D1421A71CC0A5B1 CRC64;
     MEQIKYLLIG IIFSSAISSS LQCAYENCAD WANPGQSQKH TMCLYPTTAL GNKCNEGRII
     QLTEADKQYI LQLHNELRAK VASGGESQGS NGPQPAGKIG PLKWDNEIAE IAQRWVNQCT
     FEHDKCRNTK ANSVGQNLYM MGSSEKSENT HDILTASVNS WYSEVKDFDN RSVREYKFEF
     TTGHYSQVVW GDTTHVGCGL VQYKDSGFYT TMVACNYSPA GNLIGGTVYP TL