ID   VA5_POLAN               Reviewed;         209 AA.
AC   Q05109;
DT   01-FEB-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1994, sequence version 1.
DT   25-MAY-2022, entry version 87.
DE   RecName: Full=Venom allergen 5;
DE   AltName: Full=Allergen Pol a V;
DE   AltName: Full=Antigen 5;
DE            Short=Ag5;
DE   AltName: Full=Cysteine-rich venom protein;
DE            Short=CRVP;
DE   AltName: Allergen=Pol a 5;
DE   Flags: Precursor; Fragment;
OS   Polistes annularis (Paper wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Polistinae; Polistini; Polistes.
OX   NCBI_TaxID=27505;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], AND PARTIAL PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   PubMed=8454859;
RA   Lu G., Villalba M., Coscia M.R., Hoffman D.R., King T.P.;
RT   "Sequence analysis and antigenic cross-reactivity of a venom allergen,
RT   antigen 5, from hornets, wasps, and yellow jackets.";
RL   J. Immunol. 150:2823-2830(1993).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the CRISP family. Venom allergen 5-like
CC       subfamily. {ECO:0000305}.
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DR   EMBL; M98857; AAA29793.1; -; mRNA.
DR   AlphaFoldDB; Q05109; -.
DR   SMR; Q05109; -.
DR   Allergome; 3432; Pol a 5.0101.
DR   Allergome; 585; Pol a 5.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR002413; V5_allergen-like.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00838; V5ALLERGEN.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   PROSITE; PS01009; CRISP_1; 1.
DR   PROSITE; PS01010; CRISP_2; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Secreted; Signal.
FT   SIGNAL          <1..4
FT                   /evidence="ECO:0000250"
FT   CHAIN           5..209
FT                   /note="Venom allergen 5"
FT                   /id="PRO_0000006296"
FT   DOMAIN          52..194
FT                   /note="SCP"
FT   DISULFID        8..20
FT                   /evidence="ECO:0000250"
FT   DISULFID        12..108
FT                   /evidence="ECO:0000250"
FT   DISULFID        32..100
FT                   /evidence="ECO:0000250"
FT   DISULFID        175..192
FT                   /evidence="ECO:0000250"
FT   NON_TER         1
SQ   SEQUENCE   209 AA;  23293 MW;  39BDA2DB51BF555B CRC64;
     SSQGVDYCKI KCPSGIHTVC QYGESTKPSK NCAGKVIKSV GPTEEEKKLI VSEHNRFRQK
     VAQGLETRGN PGPQPAASDM NDLVWNDELA HIAQVWASQC QFLVHDKCRN TAKYPVGQNI
     AYAGGSNLPD VVSLIKLWEN EVKDFNYNTG ITKQNFAKIG HYTQMVWGKT KEIGCGSLKY
     MENNMQNHYL ICNYGPAGNY LGQLPYTKK