ID   VA5_POLEX               Reviewed;         226 AA.
AC   P35759; Q68KJ9;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   25-MAY-2022, entry version 81.
DE   RecName: Full=Venom allergen 5;
DE   AltName: Full=Allergen Pol e V;
DE   AltName: Full=Antigen 5;
DE            Short=Ag5;
DE   AltName: Full=Cysteine-rich venom protein;
DE            Short=CRVP;
DE   AltName: Allergen=Pol e 5;
DE   Flags: Precursor;
OS   Polistes exclamans (Paper wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Polistinae; Polistini; Polistes.
OX   NCBI_TaxID=27506;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Morris P.R., Schmidt M., Hoffman D.R.;
RT   "Nucleotide sequences of paper wasp venom antigen 5.";
RL   Submitted (JUL-2004) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   PROTEIN SEQUENCE OF 22-226.
RC   TISSUE=Venom;
RX   PubMed=8454859;
RA   Lu G., Villalba M., Coscia M.R., Hoffman D.R., King T.P.;
RT   "Sequence analysis and antigenic cross-reactivity of a venom allergen,
RT   antigen 5, from hornets, wasps, and yellow jackets.";
RL   J. Immunol. 150:2823-2830(1993).
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the CRISP family. Venom allergen 5-like
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AY684999; AAT95009.1; -; mRNA.
DR   PIR; A37329; A37329.
DR   AlphaFoldDB; P35759; -.
DR   SMR; P35759; -.
DR   Allergome; 3441; Pol e 5.0101.
DR   Allergome; 591; Pol e 5.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR002413; V5_allergen-like.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00838; V5ALLERGEN.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   PROSITE; PS01009; CRISP_1; 1.
DR   PROSITE; PS01010; CRISP_2; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000269|PubMed:8454859"
FT   CHAIN           22..226
FT                   /note="Venom allergen 5"
FT                   /id="PRO_0000211535"
FT   DOMAIN          69..211
FT                   /note="SCP"
FT   DISULFID        25..37
FT                   /evidence="ECO:0000250"
FT   DISULFID        29..125
FT                   /evidence="ECO:0000250"
FT   DISULFID        49..117
FT                   /evidence="ECO:0000250"
FT   DISULFID        192..209
FT                   /evidence="ECO:0000250"
FT   CONFLICT        28
FT                   /note="R -> K (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        198
FT                   /note="M -> I (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        223
FT                   /note="N -> Y (in Ref. 2; AA sequence)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   226 AA;  25122 MW;  2B64A7586E375039 CRC64;
     MEIGGLVYLV IVVAIIHSSQ GVDYCKIRCP SGIHTVCQYG ESTKPSKNCA GKVIKSVGPT
     EEEKKLIVSE HNRFRQKVAQ GLETRGNPGP QPAASDMNDL VWNDELAHIA QVWASQCQFL
     VHDKCRNTAK YPVGQNIAYA GGSKLPDVVS LIKLWENEVK DFNYNTGITK QNFAKIGHYT
     QMVWGKTKEI GCGSLKYMEN KMQNHYLICN YGPAGNYLGQ LPNTKK