ID   VA5_POLGA               Reviewed;         206 AA.
AC   P83377;
DT   15-NOV-2002, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Venom allergen 5;
DE   AltName: Full=Antigen 5;
DE            Short=Ag5;
DE   AltName: Full=Cysteine-rich venom protein;
DE            Short=CRVP;
DE   AltName: Allergen=Pol g 5;
OS   Polistes gallicus (Paper wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Polistinae; Polistini; Polistes.
OX   NCBI_TaxID=34730 {ECO:0000305};
RN   [1]
RP   PROTEIN SEQUENCE, AND SUBCELLULAR LOCATION.
RC   TISSUE=Venom;
RX   PubMed=14572904; DOI=10.1016/j.bbagen.2003.07.001;
RA   Pantera B., Hoffman D.R., Carresi L., Cappugi G., Turillazzi S., Manao G.,
RA   Severino M., Spadolini I., Orsomando G., Moneti G., Pazzagli L.;
RT   "Characterization of the major allergens purified from the venom of the
RT   paper wasp Polistes gallicus.";
RL   Biochim. Biophys. Acta 1623:72-81(2003).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:14572904}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the CRISP family. Venom allergen 5-like
CC       subfamily. {ECO:0000305}.
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DR   AlphaFoldDB; P83377; -.
DR   SMR; P83377; -.
DR   Allergome; 3444; Pol g 5.0101.
DR   Allergome; 708; Pol g 5.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR002413; V5_allergen-like.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00838; V5ALLERGEN.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   PROSITE; PS01009; CRISP_1; 1.
DR   PROSITE; PS01010; CRISP_2; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Secreted.
FT   CHAIN           1..206
FT                   /note="Venom allergen 5"
FT                   /id="PRO_0000211537"
FT   DOMAIN          48..191
FT                   /note="SCP"
FT   DISULFID        4..16
FT                   /evidence="ECO:0000250"
FT   DISULFID        8..104
FT                   /evidence="ECO:0000250"
FT   DISULFID        28..96
FT                   /evidence="ECO:0000250"
FT   DISULFID        172..189
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   206 AA;  23153 MW;  FF4FA7D5AD9B5053 CRC64;
     NDYCKIKCSS GVHTVCQYGE STKPSKNCAG KVIKSVGPTE EEKKLIVEEH NRFRQKVAQG
     LETRGNPGPQ PAASNMNNLV WNDEQAKIAQ VWASQCQILV HDKCRNTEKY QVGQNIAYAG
     SSNHFPSVTK LIQLWENEVK DFNYNTGITN KNFGKVGHYT QMVWGNTKEV GCGSLKYVEK
     NMKIHYLICN YGPAGNYLGQ PIYTKK