ID   VA5_POLSR               Reviewed;         207 AA.
AC   Q7Z156; P82958;
DT   10-MAY-2004, integrated into UniProtKB/Swiss-Prot.
DT   02-FEB-2004, sequence version 2.
DT   25-MAY-2022, entry version 65.
DE   RecName: Full=Venom allergen 5;
DE   AltName: Full=Allergen Pol s V;
DE   AltName: Full=Antigen 5;
DE            Short=Ag5;
DE   AltName: Full=Cysteine-rich venom protein;
DE            Short=CRVP;
DE   AltName: Allergen=Pol s 5;
OS   Polybia scutellaris rioplatensis (Camoati).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Polistinae; Epiponini; Polybia.
OX   NCBI_TaxID=260979;
RN   [1] {ECO:0000305}
RP   PROTEIN SEQUENCE, SUBUNIT, TISSUE SPECIFICITY, AND ALLERGEN.
RC   TISSUE=Venom {ECO:0000269|PubMed:12413495};
RX   PubMed=12413495; DOI=10.1016/s0003-9861(02)00554-4;
RA   Pirpignani M.L., Rivera E., Hellman U., Biscoglio de Jimenez Bonino M.;
RT   "Structural and immunological aspects of Polybia scutellaris antigen 5.";
RL   Arch. Biochem. Biophys. 407:224-230(2002).
RN   [2] {ECO:0000312|EMBL:AAP57536.1}
RP   NUCLEOTIDE SEQUENCE [MRNA].
RA   Pirpignani M.L., King T.P., Biscoglio M.;
RT   "cDNA cloning of Polybia scutellaris Ag5.";
RL   Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBUNIT: Monomer. {ECO:0000269|PubMed:12413495}.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:12413495}.
CC   -!- ALLERGEN: Causes an allergic reaction in human. In most vespids,
CC       Antigen 5 is a potent allergen. Pol s 5 is a variant with a much lower
CC       allergenicity. It has a reduced IgE response and anaphylactic activity.
CC       {ECO:0000269|PubMed:12413495}.
CC   -!- SIMILARITY: Belongs to the CRISP family. Venom allergen 5-like
CC       subfamily. {ECO:0000305}.
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DR   EMBL; AY299635; AAP57536.1; -; mRNA.
DR   AlphaFoldDB; Q7Z156; -.
DR   SMR; Q7Z156; -.
DR   Allergome; 3494; Poly s 5.0101.
DR   Allergome; 771; Poly s 5.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR002413; V5_allergen-like.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00838; V5ALLERGEN.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   PROSITE; PS01009; CRISP_1; 1.
DR   PROSITE; PS01010; CRISP_2; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Secreted.
FT   CHAIN           1..207
FT                   /note="Venom allergen 5"
FT                   /id="PRO_0000211538"
FT   DOMAIN          48..192
FT                   /note="SCP"
FT   DISULFID        4..16
FT                   /evidence="ECO:0000250|UniProtKB:P10736"
FT   DISULFID        8..105
FT                   /evidence="ECO:0000250|UniProtKB:P10736"
FT   DISULFID        29..97
FT                   /evidence="ECO:0000250|UniProtKB:P10736"
FT   DISULFID        173..190
FT                   /evidence="ECO:0000250|UniProtKB:P10736"
FT   CONFLICT        28
FT                   /note="Missing (in Ref. 2; AAP57536)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        95
FT                   /note="N -> S (in Ref. 2; AAP57536)"
FT                   /evidence="ECO:0000305"
FT   CONFLICT        155
FT                   /note="A -> S (in Ref. 2; AAP57536)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   207 AA;  23209 MW;  35E2D236344DF74C CRC64;
     NKYCNIKCSK VAHTVCQYGE STKPSSKNCN KVSITSVGVT EEEKKLIVDE HNRFRQKVAQ
     GLETRGNPGP QPAASDMNNL VWNDELAYIA QVWANQCQFF VHDKCRNTAQ YQVGQNIAYS
     ASTAAYPGIV SLIVLWENEV KDFNYSQGIT KENFAKVGHY TQVVWAKTKE VGCGSIKYIE
     KGMKSHYLVC NYGPAGNYMG QPIYTKK