ID   VA5_RHYBR               Reviewed;         228 AA.
AC   B2MVK7;
DT   30-NOV-2010, integrated into UniProtKB/Swiss-Prot.
DT   10-JUN-2008, sequence version 1.
DT   25-MAY-2022, entry version 28.
DE   RecName: Full=Venom allergen 5;
DE   AltName: Full=Antigen 5;
DE   AltName: Full=Cysteine-rich venom protein;
DE            Short=CRVP;
DE   Flags: Precursor;
OS   Rhynchium brunneum (Potter wasp).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Eumeninae; Rhynchium.
OX   NCBI_TaxID=522437;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Venom gland;
RA   Xu J., Han Z.;
RT   "Cloning and sequence analysis of two genes for venom allergens from
RT   Rhynchium brunneum Fabricius.";
RL   Submitted (APR-2008) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- ALLERGEN: Causes an allergic reaction in human. {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the CRISP family. Venom allergen 5-like
CC       subfamily. {ECO:0000305}.
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DR   EMBL; EU624136; ACC93935.1; -; mRNA.
DR   AlphaFoldDB; B2MVK7; -.
DR   SMR; B2MVK7; -.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR002413; V5_allergen-like.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00838; V5ALLERGEN.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   PROSITE; PS01009; CRISP_1; 1.
DR   PROSITE; PS01010; CRISP_2; 1.
PE   2: Evidence at transcript level;
KW   Allergen; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..22
FT                   /evidence="ECO:0000255"
FT   CHAIN           23..228
FT                   /note="Venom allergen 5"
FT                   /id="PRO_0000401931"
FT   DOMAIN          69..214
FT                   /note="SCP"
FT   DISULFID        30..124
FT                   /evidence="ECO:0000250"
FT   DISULFID        51..117
FT                   /evidence="ECO:0000250"
FT   DISULFID        195..212
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   228 AA;  25262 MW;  7295BD1C9BFB25E4 CRC64;
     MTKIDLLARV FVIATIIALA TAVDYYKLKC PPKTKHTMCI YGTNSHPSRN CGVVKGSGPT
     DQEKREILKE HNDYGHKVAS GEEKRGVNGG QPAAKNMEDM TWDDELAKVA QTWANQCTIN
     HDKCRSVSRF SVGQNLASKS TTGNDFPPVV ELIQLWENEV SDFDKNNIKS LPASGISKTG
     HYTQMVWAKS NKLGCGSIKH HKDGWNKHFL VCNYGPSGNY LGQSVYEV