ID   VA5_VESFL               Reviewed;         204 AA.
AC   P35783;
DT   01-JUN-1994, integrated into UniProtKB/Swiss-Prot.
DT   01-JUN-1994, sequence version 1.
DT   25-MAY-2022, entry version 83.
DE   RecName: Full=Venom allergen 5;
DE   AltName: Full=Allergen Ves f V;
DE   AltName: Full=Antigen 5;
DE            Short=Ag5;
DE   AltName: Full=Cysteine-rich venom protein;
DE            Short=CRVP;
DE   AltName: Allergen=Ves f 5;
OS   Vespula flavopilosa (Downy yellowjacket).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Vespinae; Vespula.
OX   NCBI_TaxID=30211;
RN   [1]
RP   PROTEIN SEQUENCE.
RC   TISSUE=Venom;
RX   PubMed=8227862; DOI=10.1016/0091-6749(93)90014-7;
RA   Hoffman D.R.;
RT   "Allergens in Hymenoptera venom. XXV: the amino acid sequences of antigen 5
RT   molecules and the structural basis of antigenic cross-reactivity.";
RL   J. Allergy Clin. Immunol. 92:707-716(1993).
CC   -!- FUNCTION: May have an ancestral function in the promotion of ovum
CC       fertilization by sperm.
CC   -!- SUBCELLULAR LOCATION: Secreted.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC   -!- SIMILARITY: Belongs to the CRISP family. Venom allergen 5-like
CC       subfamily. {ECO:0000305}.
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DR   PIR; A44583; A44583.
DR   AlphaFoldDB; P35783; -.
DR   SMR; P35783; -.
DR   Allergome; 3512; Ves f 5.0101.
DR   Allergome; 658; Ves f 5.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR002413; V5_allergen-like.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00838; V5ALLERGEN.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   PROSITE; PS01009; CRISP_1; 1.
DR   PROSITE; PS01010; CRISP_2; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Secreted.
FT   CHAIN           1..204
FT                   /note="Venom allergen 5"
FT                   /id="PRO_0000211541"
FT   DOMAIN          45..189
FT                   /note="SCP"
FT   DISULFID        4..17
FT                   /evidence="ECO:0000250"
FT   DISULFID        8..101
FT                   /evidence="ECO:0000250"
FT   DISULFID        26..94
FT                   /evidence="ECO:0000250"
FT   DISULFID        170..187
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   204 AA;  23274 MW;  7667232536AB2FC5 CRC64;
     NNYCKIKCLK GGVHTACKYG SLKPNCGNKV VVSYGLTKQE KQDILKEHND FRQKIARGLE
     TRGNPGPQPP AKNMKNLVWN DELAYVAQVW ANQCQYGHDT CRDIAKYQVG QNVALTGSTA
     AKYDDPVKLV KMWEDEVKDY NPKKKFSGNN FLKTGHYTQM VWANTKEVGC GSIKFIQEKW
     HKHYLVCNYG PSGNFQNEEL YQTK