ID   CAH3_CAEEL              Reviewed;         246 AA.
AC   Q27504;
DT   23-MAY-2003, integrated into UniProtKB/Swiss-Prot.
DT   01-NOV-1996, sequence version 1.
DT   03-AUG-2022, entry version 140.
DE   RecName: Full=Putative carbonic anhydrase 3;
DE            EC=4.2.1.1;
DE   AltName: Full=Carbonate dehydratase 3;
GN   Name=cah-3; ORFNames=K05G3.3;
OS   Caenorhabditis elegans.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6239;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Bristol N2;
RX   PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG   The C. elegans sequencing consortium;
RT   "Genome sequence of the nematode C. elegans: a platform for investigating
RT   biology.";
RL   Science 282:2012-2018(1998).
CC   -!- FUNCTION: Reversible hydration of carbon dioxide.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=H(+) + hydrogencarbonate = CO2 + H2O; Xref=Rhea:RHEA:10748,
CC         ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:16526,
CC         ChEBI:CHEBI:17544; EC=4.2.1.1;
CC   -!- COFACTOR:
CC       Name=Zn(2+); Xref=ChEBI:CHEBI:29105;
CC         Evidence={ECO:0000250|UniProtKB:P07451};
CC   -!- SIMILARITY: Belongs to the alpha-carbonic anhydrase family.
CC       {ECO:0000305}.
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DR   EMBL; FO081593; CCD72692.1; -; Genomic_DNA.
DR   PIR; T16575; T16575.
DR   RefSeq; NP_510674.1; NM_078273.6.
DR   AlphaFoldDB; Q27504; -.
DR   SMR; Q27504; -.
DR   BioGRID; 46597; 2.
DR   IntAct; Q27504; 1.
DR   MINT; Q27504; -.
DR   STRING; 6239.K05G3.3; -.
DR   EPD; Q27504; -.
DR   PaxDb; Q27504; -.
DR   PeptideAtlas; Q27504; -.
DR   EnsemblMetazoa; K05G3.3.1; K05G3.3.1; WBGene00000281.
DR   GeneID; 181713; -.
DR   UCSC; K05G3.3; c. elegans.
DR   CTD; 181713; -.
DR   WormBase; K05G3.3; CE04755; WBGene00000281; cah-3.
DR   eggNOG; KOG0382; Eukaryota.
DR   HOGENOM; CLU_039326_2_2_1; -.
DR   InParanoid; Q27504; -.
DR   OMA; YCDDDEC; -.
DR   OrthoDB; 1377476at2759; -.
DR   PhylomeDB; Q27504; -.
DR   PRO; PR:Q27504; -.
DR   Proteomes; UP000001940; Chromosome X.
DR   Bgee; WBGene00000281; Expressed in larva and 6 other tissues.
DR   GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR   GO; GO:0004089; F:carbonate dehydratase activity; IBA:GO_Central.
DR   GO; GO:0016836; F:hydro-lyase activity; IBA:GO_Central.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006730; P:one-carbon metabolic process; IBA:GO_Central.
DR   Gene3D; 3.10.200.10; -; 1.
DR   InterPro; IPR001148; CA_dom.
DR   InterPro; IPR036398; CA_dom_sf.
DR   InterPro; IPR023561; Carbonic_anhydrase_a-class.
DR   InterPro; IPR018338; Carbonic_anhydrase_a-class_CS.
DR   PANTHER; PTHR18952; PTHR18952; 1.
DR   Pfam; PF00194; Carb_anhydrase; 1.
DR   SMART; SM01057; Carb_anhydrase; 1.
DR   SUPFAM; SSF51069; SSF51069; 1.
DR   PROSITE; PS00162; ALPHA_CA_1; 1.
DR   PROSITE; PS51144; ALPHA_CA_2; 1.
PE   3: Inferred from homology;
KW   Lyase; Metal-binding; Reference proteome; Zinc.
FT   CHAIN           1..246
FT                   /note="Putative carbonic anhydrase 3"
FT                   /id="PRO_0000077444"
FT   DOMAIN          3..244
FT                   /note="Alpha-carbonic anhydrase"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU01134"
FT   ACT_SITE        61
FT                   /note="Proton acceptor"
FT                   /evidence="ECO:0000250|UniProtKB:P00918"
FT   BINDING         91
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:P00918"
FT   BINDING         93
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:P00918"
FT   BINDING         116
FT                   /ligand="Zn(2+)"
FT                   /ligand_id="ChEBI:CHEBI:29105"
FT                   /ligand_note="catalytic"
FT                   /evidence="ECO:0000250|UniProtKB:P00918"
FT   BINDING         187..188
FT                   /ligand="substrate"
FT                   /evidence="ECO:0000250|UniProtKB:P00918"
SQ   SEQUENCE   246 AA;  28121 MW;  E5A405E23A17719C CRC64;
     MTGHWSYCDD DECGPNRWPT GQHQSPINID LGEVERKDTH DGIKFVNYDH PIQGDIVNNG
     HSVQMTPELR SEHPEIYGGG LDQVYRLVQY HFHWGENDNE GSEHTLGGLR YPAELHLVHQ
     GVEDPGKLAV VGVFLQLGKE GKALSNEERV LGKLCNPETV TRVENVRLSE KLPANKRSFW
     RYEGSLTTPP CSEIVTWTIF TEPVTVTHDQ LELFRQVQDI EKRPIKKNYR PTQNLNDRKI
     VHIVAN