ID   VA5_VESMG               Reviewed;         225 AA.
AC   P86870; E8ZX84;
DT   08-MAR-2011, integrated into UniProtKB/Swiss-Prot.
DT   03-OCT-2012, sequence version 2.
DT   25-MAY-2022, entry version 22.
DE   RecName: Full=Venom allergen 5 {ECO:0000250|UniProtKB:P81657};
DE   AltName: Full=Antigen 5;
DE            Short=Ag5 {ECO:0000250|UniProtKB:P81657};
DE   AltName: Full=Cysteine-rich venom protein;
DE            Short=CRVP;
DE   AltName: Allergen=Vesp ma 5;
DE   Flags: Precursor;
OS   Vespa magnifica (Hornet).
OC   Eukaryota; Metazoa; Ecdysozoa; Arthropoda; Hexapoda; Insecta; Pterygota;
OC   Neoptera; Endopterygota; Hymenoptera; Apocrita; Aculeata; Vespoidea;
OC   Vespidae; Vespinae; Vespa.
OX   NCBI_TaxID=202807;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], PROTEIN SEQUENCE OF 24-48; 96-117; 130-152;
RP   172-184 AND 204-220, SUBCELLULAR LOCATION, TISSUE SPECIFICITY, AND
RP   ALLERGEN.
RC   TISSUE=Venom, and Venom gland;
RX   PubMed=22384100; DOI=10.1371/journal.pone.0031920;
RA   An S., Chen L., Wei J.F., Yang X., Ma D., Xu X., Xu X., He S., Lu J.,
RA   Lai R.;
RT   "Purification and characterization of two new allergens from the venom of
RT   Vespa magnifica.";
RL   PLoS ONE 7:E31920-E31920(2012).
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000269|PubMed:22384100}.
CC   -!- TISSUE SPECIFICITY: Expressed by the venom gland.
CC       {ECO:0000269|PubMed:22384100}.
CC   -!- ALLERGEN: Causes an allergic reaction in human.
CC       {ECO:0000269|PubMed:22384100}.
CC   -!- SIMILARITY: Belongs to the CRISP family. Venom allergen 5-like
CC       subfamily. {ECO:0000305}.
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DR   EMBL; FR774918; CBY93636.1; -; mRNA.
DR   AlphaFoldDB; P86870; -.
DR   SMR; P86870; -.
DR   Allergome; 9487; Vesp ma 5.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   Gene3D; 3.40.33.10; -; 1.
DR   InterPro; IPR018244; Allrgn_V5/Tpx1_CS.
DR   InterPro; IPR014044; CAP_domain.
DR   InterPro; IPR035940; CAP_sf.
DR   InterPro; IPR001283; CRISP-related.
DR   InterPro; IPR002413; V5_allergen-like.
DR   PANTHER; PTHR10334; PTHR10334; 1.
DR   Pfam; PF00188; CAP; 1.
DR   PRINTS; PR00838; V5ALLERGEN.
DR   PRINTS; PR00837; V5TPXLIKE.
DR   SMART; SM00198; SCP; 1.
DR   SUPFAM; SSF55797; SSF55797; 1.
DR   PROSITE; PS01009; CRISP_1; 1.
DR   PROSITE; PS01010; CRISP_2; 1.
PE   1: Evidence at protein level;
KW   Allergen; Direct protein sequencing; Disulfide bond; Secreted; Signal.
FT   SIGNAL          1..23
FT                   /evidence="ECO:0000269|PubMed:22384100"
FT   CHAIN           24..225
FT                   /note="Venom allergen 5"
FT                   /id="PRO_5000706181"
FT   DOMAIN          69..210
FT                   /note="SCP"
FT   DISULFID        27..39
FT                   /evidence="ECO:0000250"
FT   DISULFID        31..124
FT                   /evidence="ECO:0000250"
FT   DISULFID        49..117
FT                   /evidence="ECO:0000250"
FT   DISULFID        191..208
FT                   /evidence="ECO:0000250"
SQ   SEQUENCE   225 AA;  25137 MW;  378654AEB49FEE53 CRC64;
     MKISGFVYLI LITTIINLSF SEANNYCKIK CRSGIHTLCK FGISTKPNCG KNVVKGSGLT
     KAEKLEILKQ HNEFRQKVAR GLETRGKPGP QPPAKSMNTL VWNDELAQIA QVWASQCKYG
     HDDCRNTAKH SVGQNIAQQS TTAASFGSVS NMVQMWADEV KNYQYGSTKN KLIEVGHYTQ
     MVWAKTKEIG CGSIKYIENG WHRHYLVCNY GPAGNIGNEP IYEKK