VA721_ARATH
ID VA721_ARATH Reviewed; 219 AA.
AC Q9ZTW3; O23011; Q9MAS4;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAY-1999, sequence version 1.
DT 03-AUG-2022, entry version 158.
DE RecName: Full=Vesicle-associated membrane protein 721 {ECO:0000303|PubMed:11115874};
DE Short=AtVAMP721 {ECO:0000303|PubMed:11115874};
DE AltName: Full=v-SNARE synaptobrevin 7B {ECO:0000303|Ref.1};
DE Short=AtVAMP7B {ECO:0000303|Ref.1};
GN Name=VAMP721 {ECO:0000303|PubMed:11115874};
GN Synonyms=VAMP7B {ECO:0000303|Ref.1};
GN OrderedLocusNames=At1g04750 {ECO:0000312|Araport:AT1G04750};
GN ORFNames=F13M7.26 {ECO:0000312|EMBL:AAF40468.1}, F13M7_23,
GN T1G11.1 {ECO:0000312|EMBL:AAB80624.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA].
RC TISSUE=Flower, Rosette leaf, Seedling, Silique, and Stem;
RA Nikoloff D.M., Somerville C.R.;
RL Submitted (SEP-1997) to the EMBL/GenBank/DDBJ databases.
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [3]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [4]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [5]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11115874; DOI=10.1104/pp.124.4.1558;
RA Sanderfoot A.A., Assaad F.F., Raikhel N.V.;
RT "The Arabidopsis genome. An abundance of soluble N-ethylmaleimide-sensitive
RT factor adaptor protein receptors.";
RL Plant Physiol. 124:1558-1569(2000).
RN [6]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=15342965; DOI=10.1247/csf.29.49;
RA Uemura T., Ueda T., Ohniwa R.L., Nakano A., Takeyasu K., Sato M.H.;
RT "Systematic analysis of SNARE molecules in Arabidopsis: dissection of the
RT post-Golgi network in plant cells.";
RL Cell Struct. Funct. 29:49-65(2004).
CC -!- FUNCTION: Involved in the targeting and/or fusion of transport vesicles
CC to their target membrane. {ECO:0000305|PubMed:11115874}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15342965};
CC Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q12255}.
CC Early endosome membrane {ECO:0000269|PubMed:15342965}; Single-pass type
CC IV membrane protein {ECO:0000250|UniProtKB:Q12255}.
CC -!- ALTERNATIVE PRODUCTS:
CC Event=Alternative splicing; Named isoforms=1;
CC Comment=A number of isoforms are produced. According to EST
CC sequences.;
CC Name=1;
CC IsoId=Q9ZTW3-1; Sequence=Displayed;
CC -!- TISSUE SPECIFICITY: Expressed in flowers, leaves, stems and roots.
CC {ECO:0000269|PubMed:15342965}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAB80624.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
CC Sequence=AAF40468.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AF025333; AAC98905.1; -; mRNA.
DR EMBL; AC002376; AAB80624.1; ALT_SEQ; Genomic_DNA.
DR EMBL; AC004809; AAF40468.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE27738.1; -; Genomic_DNA.
DR EMBL; AY079164; AAL85003.1; -; mRNA.
DR EMBL; AY133661; AAM91491.1; -; mRNA.
DR PIR; D86180; D86180.
DR PIR; E86180; E86180.
DR RefSeq; NP_171967.1; NM_100353.4. [Q9ZTW3-1]
DR AlphaFoldDB; Q9ZTW3; -.
DR SMR; Q9ZTW3; -.
DR BioGRID; 24654; 18.
DR IntAct; Q9ZTW3; 7.
DR STRING; 3702.AT1G04750.1; -.
DR iPTMnet; Q9ZTW3; -.
DR PaxDb; Q9ZTW3; -.
DR PRIDE; Q9ZTW3; -.
DR ProteomicsDB; 243253; -. [Q9ZTW3-1]
DR EnsemblPlants; AT1G04750.1; AT1G04750.1; AT1G04750. [Q9ZTW3-1]
DR GeneID; 839419; -.
DR Gramene; AT1G04750.1; AT1G04750.1; AT1G04750. [Q9ZTW3-1]
DR KEGG; ath:AT1G04750; -.
DR Araport; AT1G04750; -.
DR TAIR; locus:2010642; AT1G04750.
DR eggNOG; KOG0859; Eukaryota.
DR HOGENOM; CLU_064620_1_0_1; -.
DR InParanoid; Q9ZTW3; -.
DR OMA; FTIACDR; -.
DR PhylomeDB; Q9ZTW3; -.
DR PRO; PR:Q9ZTW3; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9ZTW3; baseline and differential.
DR Genevisible; Q9ZTW3; AT.
DR GO; GO:0009504; C:cell plate; IDA:TAIR.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005768; C:endosome; IDA:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; HDA:TAIR.
DR GO; GO:0009506; C:plasmodesma; HDA:TAIR.
DR GO; GO:0009920; P:cell plate formation involved in plant-type cell wall biogenesis; IGI:TAIR.
DR GO; GO:0072659; P:protein localization to plasma membrane; IGI:TAIR.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0034976; P:response to endoplasmic reticulum stress; IPI:TAIR.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14824; Longin; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR001388; Synaptobrevin.
DR InterPro; IPR042855; V_SNARE_CC.
DR Pfam; PF13774; Longin; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR PRINTS; PR00219; SYNAPTOBREVN.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS50859; LONGIN; 1.
DR PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 2: Evidence at transcript level;
KW Alternative splicing; Cell membrane; Coiled coil; Endosome; Membrane;
KW Protein transport; Reference proteome; Transmembrane; Transmembrane helix;
KW Transport.
FT CHAIN 1..219
FT /note="Vesicle-associated membrane protein 721"
FT /id="PRO_0000206754"
FT TOPO_DOM 1..196
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..219
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT DOMAIN 10..114
FT /note="Longin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT DOMAIN 130..190
FT /note="v-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
SQ SEQUENCE 219 AA; 24765 MW; 7F234F6DB5138082 CRC64;
MAQQSLIYSF VARGTVILVE FTDFKGNFTS IAAQCLQKLP SSNNKFTYNC DGHTFNYLVE
DGFTYCVVAV DSAGRQIPMS FLERVKEDFN KRYGGGKAAT AQANSLNKEF GSKLKEHMQY
CMDHPDEISK LAKVKAQVSE VKGVMMENIE KVLDRGEKIE LLVDKTENLR SQAQDFRTTG
TQMRRKMWLQ NMKIKLIVLA IIIALILIIV LSVCHGFKC
