VA723_ARATH
ID VA723_ARATH Reviewed; 217 AA.
AC Q8VY69; O49322;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 01-MAR-2002, sequence version 1.
DT 03-AUG-2022, entry version 128.
DE RecName: Full=Vesicle-associated membrane protein 723 {ECO:0000303|PubMed:11115874};
DE Short=AtVAMP723 {ECO:0000303|PubMed:11115874};
GN Name=VAMP723 {ECO:0000303|PubMed:11115874};
GN OrderedLocusNames=At2g33110 {ECO:0000312|Araport:AT2G33110};
GN ORFNames=F25I18.15 {ECO:0000312|EMBL:AEC08786.1};
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=10617197; DOI=10.1038/45471;
RA Lin X., Kaul S., Rounsley S.D., Shea T.P., Benito M.-I., Town C.D.,
RA Fujii C.Y., Mason T.M., Bowman C.L., Barnstead M.E., Feldblyum T.V.,
RA Buell C.R., Ketchum K.A., Lee J.J., Ronning C.M., Koo H.L., Moffat K.S.,
RA Cronin L.A., Shen M., Pai G., Van Aken S., Umayam L., Tallon L.J.,
RA Gill J.E., Adams M.D., Carrera A.J., Creasy T.H., Goodman H.M.,
RA Somerville C.R., Copenhaver G.P., Preuss D., Nierman W.C., White O.,
RA Eisen J.A., Salzberg S.L., Fraser C.M., Venter J.C.;
RT "Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana.";
RL Nature 402:761-768(1999).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
RC STRAIN=cv. Columbia;
RX PubMed=14593172; DOI=10.1126/science.1088305;
RA Yamada K., Lim J., Dale J.M., Chen H., Shinn P., Palm C.J., Southwick A.M.,
RA Wu H.C., Kim C.J., Nguyen M., Pham P.K., Cheuk R.F., Karlin-Newmann G.,
RA Liu S.X., Lam B., Sakano H., Wu T., Yu G., Miranda M., Quach H.L.,
RA Tripp M., Chang C.H., Lee J.M., Toriumi M.J., Chan M.M., Tang C.C.,
RA Onodera C.S., Deng J.M., Akiyama K., Ansari Y., Arakawa T., Banh J.,
RA Banno F., Bowser L., Brooks S.Y., Carninci P., Chao Q., Choy N., Enju A.,
RA Goldsmith A.D., Gurjal M., Hansen N.F., Hayashizaki Y., Johnson-Hopson C.,
RA Hsuan V.W., Iida K., Karnes M., Khan S., Koesema E., Ishida J., Jiang P.X.,
RA Jones T., Kawai J., Kamiya A., Meyers C., Nakajima M., Narusaka M.,
RA Seki M., Sakurai T., Satou M., Tamse R., Vaysberg M., Wallender E.K.,
RA Wong C., Yamamura Y., Yuan S., Shinozaki K., Davis R.W., Theologis A.,
RA Ecker J.R.;
RT "Empirical analysis of transcriptional activity in the Arabidopsis
RT genome.";
RL Science 302:842-846(2003).
RN [4]
RP GENE FAMILY, AND NOMENCLATURE.
RX PubMed=11115874; DOI=10.1104/pp.124.4.1558;
RA Sanderfoot A.A., Assaad F.F., Raikhel N.V.;
RT "The Arabidopsis genome. An abundance of soluble N-ethylmaleimide-sensitive
RT factor adaptor protein receptors.";
RL Plant Physiol. 124:1558-1569(2000).
RN [5]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=15342965; DOI=10.1247/csf.29.49;
RA Uemura T., Ueda T., Ohniwa R.L., Nakano A., Takeyasu K., Sato M.H.;
RT "Systematic analysis of SNARE molecules in Arabidopsis: dissection of the
RT post-Golgi network in plant cells.";
RL Cell Struct. Funct. 29:49-65(2004).
CC -!- FUNCTION: Involved in the targeting and/or fusion of transport vesicles
CC to their target membrane. {ECO:0000305|PubMed:11115874}.
CC -!- SUBCELLULAR LOCATION: Endoplasmic reticulum membrane
CC {ECO:0000269|PubMed:15342965}; Single-pass type IV membrane protein
CC {ECO:0000250|UniProtKB:Q12255}.
CC -!- TISSUE SPECIFICITY: Highly expressed in stems and roots. Detected in
CC flowers and leaves. {ECO:0000269|PubMed:15342965}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAC04922.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC002334; AAC04922.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002685; AEC08786.1; -; Genomic_DNA.
DR EMBL; AY072400; AAL62392.1; -; mRNA.
DR EMBL; BT000209; AAN15528.1; -; mRNA.
DR PIR; E84741; E84741.
DR RefSeq; NP_850201.1; NM_179870.4.
DR AlphaFoldDB; Q8VY69; -.
DR SMR; Q8VY69; -.
DR BioGRID; 3220; 8.
DR IntAct; Q8VY69; 8.
DR STRING; 3702.AT2G33110.1; -.
DR PaxDb; Q8VY69; -.
DR PRIDE; Q8VY69; -.
DR ProteomicsDB; 243254; -.
DR EnsemblPlants; AT2G33110.1; AT2G33110.1; AT2G33110.
DR GeneID; 817873; -.
DR Gramene; AT2G33110.1; AT2G33110.1; AT2G33110.
DR KEGG; ath:AT2G33110; -.
DR Araport; AT2G33110; -.
DR TAIR; locus:2046490; AT2G33110.
DR eggNOG; KOG0859; Eukaryota.
DR HOGENOM; CLU_064620_1_0_1; -.
DR InParanoid; Q8VY69; -.
DR OrthoDB; 1211929at2759; -.
DR PhylomeDB; Q8VY69; -.
DR PRO; PR:Q8VY69; -.
DR Proteomes; UP000006548; Chromosome 2.
DR ExpressionAtlas; Q8VY69; baseline and differential.
DR Genevisible; Q8VY69; AT.
DR GO; GO:0005783; C:endoplasmic reticulum; TAS:TAIR.
DR GO; GO:0005789; C:endoplasmic reticulum membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14824; Longin; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR001388; Synaptobrevin.
DR InterPro; IPR042855; V_SNARE_CC.
DR Pfam; PF13774; Longin; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR PRINTS; PR00219; SYNAPTOBREVN.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS50859; LONGIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 2: Evidence at transcript level;
KW Coiled coil; Endoplasmic reticulum; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..217
FT /note="Vesicle-associated membrane protein 723"
FT /id="PRO_0000206756"
FT TOPO_DOM 1..192
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 193..213
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 214..217
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT DOMAIN 10..114
FT /note="Longin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT DOMAIN 130..186
FT /note="v-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
SQ SEQUENCE 217 AA; 24493 MW; FE270AE7E05A5097 CRC64;
MAQQSLFYSF IARGTVILVE FTDFKGNFTS VAAQYLENLP SSNNKFTYNC DGHTFNDLVE
NGFTYCVVAV DSAGREIPMA FLERVKEDFY KRYGGEKAAT DQANSLNKEF GSNLKEHMQY
CMDHPDEISN LAKAKAQVSE VKSLMMENIE KVLARGVICE MLGSSESQPQ AFYIKRTQMK
RKKWFQNMKI KLIVLAIIIA LILIIILSVC GGFNCGK
