VA726_ARATH
ID VA726_ARATH Reviewed; 220 AA.
AC Q9MAS5;
DT 17-JAN-2003, integrated into UniProtKB/Swiss-Prot.
DT 10-MAY-2005, sequence version 2.
DT 03-AUG-2022, entry version 142.
DE RecName: Full=Putative vesicle-associated membrane protein 726;
DE Short=AtVAMP726;
GN Name=VAMP726; OrderedLocusNames=At1g04760; ORFNames=F13M7.25;
OS Arabidopsis thaliana (Mouse-ear cress).
OC Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta;
OC Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae;
OC rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis.
OX NCBI_TaxID=3702;
RN [1]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=cv. Columbia;
RX PubMed=11130712; DOI=10.1038/35048500;
RA Theologis A., Ecker J.R., Palm C.J., Federspiel N.A., Kaul S., White O.,
RA Alonso J., Altafi H., Araujo R., Bowman C.L., Brooks S.Y., Buehler E.,
RA Chan A., Chao Q., Chen H., Cheuk R.F., Chin C.W., Chung M.K., Conn L.,
RA Conway A.B., Conway A.R., Creasy T.H., Dewar K., Dunn P., Etgu P.,
RA Feldblyum T.V., Feng J.-D., Fong B., Fujii C.Y., Gill J.E., Goldsmith A.D.,
RA Haas B., Hansen N.F., Hughes B., Huizar L., Hunter J.L., Jenkins J.,
RA Johnson-Hopson C., Khan S., Khaykin E., Kim C.J., Koo H.L.,
RA Kremenetskaia I., Kurtz D.B., Kwan A., Lam B., Langin-Hooper S., Lee A.,
RA Lee J.M., Lenz C.A., Li J.H., Li Y.-P., Lin X., Liu S.X., Liu Z.A.,
RA Luros J.S., Maiti R., Marziali A., Militscher J., Miranda M., Nguyen M.,
RA Nierman W.C., Osborne B.I., Pai G., Peterson J., Pham P.K., Rizzo M.,
RA Rooney T., Rowley D., Sakano H., Salzberg S.L., Schwartz J.R., Shinn P.,
RA Southwick A.M., Sun H., Tallon L.J., Tambunga G., Toriumi M.J., Town C.D.,
RA Utterback T., Van Aken S., Vaysberg M., Vysotskaia V.S., Walker M., Wu D.,
RA Yu G., Fraser C.M., Venter J.C., Davis R.W.;
RT "Sequence and analysis of chromosome 1 of the plant Arabidopsis thaliana.";
RL Nature 408:816-820(2000).
RN [2]
RP GENOME REANNOTATION.
RC STRAIN=cv. Columbia;
RX PubMed=27862469; DOI=10.1111/tpj.13415;
RA Cheng C.Y., Krishnakumar V., Chan A.P., Thibaud-Nissen F., Schobel S.,
RA Town C.D.;
RT "Araport11: a complete reannotation of the Arabidopsis thaliana reference
RT genome.";
RL Plant J. 89:789-804(2017).
RN [3]
RP TISSUE SPECIFICITY, AND SUBCELLULAR LOCATION.
RX PubMed=15342965; DOI=10.1247/csf.29.49;
RA Uemura T., Ueda T., Ohniwa R.L., Nakano A., Takeyasu K., Sato M.H.;
RT "Systematic analysis of SNARE molecules in Arabidopsis: dissection of the
RT post-Golgi network in plant cells.";
RL Cell Struct. Funct. 29:49-65(2004).
CC -!- FUNCTION: Involved in the targeting and/or fusion of transport vesicles
CC to their target membrane. {ECO:0000250}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000269|PubMed:15342965};
CC Single-pass type IV membrane protein {ECO:0000250|UniProtKB:Q12255}.
CC Early endosome membrane {ECO:0000269|PubMed:15342965}; Single-pass type
CC IV membrane protein {ECO:0000250|UniProtKB:Q12255}.
CC -!- TISSUE SPECIFICITY: Expressed in flowers, leaves, stems and roots.
CC {ECO:0000269|PubMed:15342965}.
CC -!- SIMILARITY: Belongs to the synaptobrevin family. {ECO:0000305}.
CC -!- SEQUENCE CAUTION:
CC Sequence=AAF40460.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};
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DR EMBL; AC004809; AAF40460.1; ALT_SEQ; Genomic_DNA.
DR EMBL; CP002684; AEE27740.1; -; Genomic_DNA.
DR EMBL; CP002684; ANM61115.1; -; Genomic_DNA.
DR PIR; F86180; F86180.
DR RefSeq; NP_001323352.1; NM_001331501.1.
DR RefSeq; NP_171968.1; NM_100354.2.
DR AlphaFoldDB; Q9MAS5; -.
DR SMR; Q9MAS5; -.
DR BioGRID; 24659; 5.
DR IntAct; Q9MAS5; 1.
DR STRING; 3702.AT1G04760.1; -.
DR PaxDb; Q9MAS5; -.
DR PRIDE; Q9MAS5; -.
DR ProteomicsDB; 243256; -.
DR EnsemblPlants; AT1G04760.1; AT1G04760.1; AT1G04760.
DR EnsemblPlants; AT1G04760.2; AT1G04760.2; AT1G04760.
DR GeneID; 839424; -.
DR Gramene; AT1G04760.1; AT1G04760.1; AT1G04760.
DR Gramene; AT1G04760.2; AT1G04760.2; AT1G04760.
DR KEGG; ath:AT1G04760; -.
DR Araport; AT1G04760; -.
DR TAIR; locus:2010627; AT1G04760.
DR eggNOG; KOG0859; Eukaryota.
DR HOGENOM; CLU_064620_1_0_1; -.
DR InParanoid; Q9MAS5; -.
DR OMA; MKYCVDN; -.
DR OrthoDB; 1211929at2759; -.
DR PhylomeDB; Q9MAS5; -.
DR PRO; PR:Q9MAS5; -.
DR Proteomes; UP000006548; Chromosome 1.
DR ExpressionAtlas; Q9MAS5; baseline and differential.
DR Genevisible; Q9MAS5; AT.
DR GO; GO:0031901; C:early endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005768; C:endosome; TAS:TAIR.
DR GO; GO:0016021; C:integral component of membrane; IEA:UniProtKB-KW.
DR GO; GO:0005886; C:plasma membrane; TAS:TAIR.
DR GO; GO:0015031; P:protein transport; IEA:UniProtKB-KW.
DR GO; GO:0016192; P:vesicle-mediated transport; IEA:InterPro.
DR CDD; cd14824; Longin; 1.
DR InterPro; IPR011012; Longin-like_dom_sf.
DR InterPro; IPR010908; Longin_dom.
DR InterPro; IPR001388; Synaptobrevin.
DR InterPro; IPR042855; V_SNARE_CC.
DR Pfam; PF13774; Longin; 1.
DR Pfam; PF00957; Synaptobrevin; 1.
DR PRINTS; PR00219; SYNAPTOBREVN.
DR SMART; SM01270; Longin; 1.
DR SUPFAM; SSF64356; SSF64356; 1.
DR PROSITE; PS50859; LONGIN; 1.
DR PROSITE; PS00417; SYNAPTOBREVIN; 1.
DR PROSITE; PS50892; V_SNARE; 1.
PE 2: Evidence at transcript level;
KW Cell membrane; Coiled coil; Endosome; Membrane; Protein transport;
KW Reference proteome; Transmembrane; Transmembrane helix; Transport.
FT CHAIN 1..220
FT /note="Putative vesicle-associated membrane protein 726"
FT /id="PRO_0000206759"
FT TOPO_DOM 1..196
FT /note="Cytoplasmic"
FT /evidence="ECO:0000255"
FT TRANSMEM 197..217
FT /note="Helical; Anchor for type IV membrane protein"
FT /evidence="ECO:0000255"
FT TOPO_DOM 218..220
FT /note="Vesicular"
FT /evidence="ECO:0000255"
FT DOMAIN 10..114
FT /note="Longin"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00231"
FT DOMAIN 130..190
FT /note="v-SNARE coiled-coil homology"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00290"
SQ SEQUENCE 220 AA; 24873 MW; F8D984AC0F118548 CRC64;
MGQQSLIYSF VARGTVILAE YTEFKGNFTS VAAQCLQKLP SSNNKFTYNC DGHTFNYLAD
NGFTYCVVVI ESAGRQIPMA FLERVKEDFN KRYGGGKAST AKANSLNKEF GSKLKEHMQY
CADHPEEISK LSKVKAQVTE VKGVMMENIE KVLDRGEKIE LLVDKTENLR SQAQDFRTQG
TKMKRKLWFE NMKIKLIVFG IIVALILIII LSVCHGFKCT
