ID   VAB15_CAEBR             Reviewed;         226 AA.
AC   Q623D4; A8WRJ4;
DT   11-SEP-2007, integrated into UniProtKB/Swiss-Prot.
DT   23-NOV-2004, sequence version 1.
DT   03-AUG-2022, entry version 112.
DE   RecName: Full=Homeobox protein vab-15;
DE   AltName: Full=Variable abnormal morphology protein 15;
GN   Name=vab-15 {ECO:0000250|UniProtKB:Q09604}; ORFNames=CBG01903;
OS   Caenorhabditis briggsae.
OC   Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC   Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC   Caenorhabditis.
OX   NCBI_TaxID=6238;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=AF16;
RX   PubMed=14624247; DOI=10.1371/journal.pbio.0000045;
RA   Stein L.D., Bao Z., Blasiar D., Blumenthal T., Brent M.R., Chen N.,
RA   Chinwalla A., Clarke L., Clee C., Coghlan A., Coulson A., D'Eustachio P.,
RA   Fitch D.H.A., Fulton L.A., Fulton R.E., Griffiths-Jones S., Harris T.W.,
RA   Hillier L.W., Kamath R., Kuwabara P.E., Mardis E.R., Marra M.A.,
RA   Miner T.L., Minx P., Mullikin J.C., Plumb R.W., Rogers J., Schein J.E.,
RA   Sohrmann M., Spieth J., Stajich J.E., Wei C., Willey D., Wilson R.K.,
RA   Durbin R.M., Waterston R.H.;
RT   "The genome sequence of Caenorhabditis briggsae: a platform for comparative
RT   genomics.";
RL   PLoS Biol. 1:166-192(2003).
CC   -!- FUNCTION: Probable transcription factor needed for the proper
CC       production of touch cell precursors. Essential for embryonic
CC       morphogenesis (By similarity). {ECO:0000250|UniProtKB:Q09604}.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000250|UniProtKB:Q09604,
CC       ECO:0000255|PROSITE-ProRule:PRU00108}.
CC   -!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000255}.
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DR   EMBL; HE601451; CAP23102.1; -; Genomic_DNA.
DR   RefSeq; XP_002643713.1; XM_002643667.1.
DR   AlphaFoldDB; Q623D4; -.
DR   SMR; Q623D4; -.
DR   STRING; 6238.CBG01903; -.
DR   EnsemblMetazoa; CBG01903.1; CBG01903.1; WBGene00025072.
DR   GeneID; 8585706; -.
DR   KEGG; cbr:CBG_01903; -.
DR   CTD; 8585706; -.
DR   WormBase; CBG01903; CBP06206; WBGene00025072; Cbr-vab-15.
DR   eggNOG; KOG0492; Eukaryota.
DR   HOGENOM; CLU_072675_2_0_1; -.
DR   InParanoid; Q623D4; -.
DR   OMA; DPVMIYF; -.
DR   OrthoDB; 1400760at2759; -.
DR   Proteomes; UP000008549; Chromosome X.
DR   GO; GO:0005634; C:nucleus; ISS:UniProtKB.
DR   GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR   GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR   GO; GO:0048598; P:embryonic morphogenesis; ISS:UniProtKB.
DR   GO; GO:0007626; P:locomotory behavior; ISS:UniProtKB.
DR   GO; GO:0007567; P:parturition; ISS:UniProtKB.
DR   GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR   CDD; cd00086; homeodomain; 1.
DR   InterPro; IPR009057; Homeobox-like_sf.
DR   InterPro; IPR017970; Homeobox_CS.
DR   InterPro; IPR001356; Homeobox_dom.
DR   InterPro; IPR020479; Homeobox_metazoa.
DR   Pfam; PF00046; Homeodomain; 1.
DR   PRINTS; PR00024; HOMEOBOX.
DR   SMART; SM00389; HOX; 1.
DR   SUPFAM; SSF46689; SSF46689; 1.
DR   PROSITE; PS00027; HOMEOBOX_1; 1.
DR   PROSITE; PS50071; HOMEOBOX_2; 1.
PE   3: Inferred from homology;
KW   Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW   Transcription; Transcription regulation.
FT   CHAIN           1..226
FT                   /note="Homeobox protein vab-15"
FT                   /id="PRO_0000302094"
FT   DNA_BIND        135..194
FT                   /note="Homeobox"
FT                   /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT   REGION          1..41
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          79..99
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        15..31
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   226 AA;  25426 MW;  49E7505F0F9B9ADD CRC64;
     MVSKAEKPKQ SGMFSVESLL ETTTPQKSSV KDENLLKPPA PITPKTPLML PGLHHMAPYF
     GAQLDPVMIY FSQTGNRLPV MSSDSSPESS ASSPLSMQHH TLPWLSSQRE DSPTSDDAKI
     QIGLTKCMLR KHKNNRKPRT PFSTQQLISL ERKFQSKQYL SIAERAEFSA SLQLTETQVK
     IWFQNRRAKS KRLQEAEVEK VKFAQVSAYA AAVNDPSLMA FYPGQW