VAB15_CAEEL
ID VAB15_CAEEL Reviewed; 225 AA.
AC Q09604;
DT 01-NOV-1995, integrated into UniProtKB/Swiss-Prot.
DT 01-NOV-1995, sequence version 1.
DT 03-AUG-2022, entry version 151.
DE RecName: Full=Homeobox protein vab-15;
DE AltName: Full=Variable abnormal morphology protein 15;
GN Name=vab-15; ORFNames=R07B1.1;
OS Caenorhabditis elegans.
OC Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida;
OC Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae;
OC Caenorhabditis.
OX NCBI_TaxID=6239;
RN [1]
RP NUCLEOTIDE SEQUENCE [MRNA], FUNCTION, SUBCELLULAR LOCATION, TISSUE
RP SPECIFICITY, DEVELOPMENTAL STAGE, AND DISRUPTION PHENOTYPE.
RC STRAIN=Bristol N2;
RX PubMed=11333230; DOI=10.1093/genetics/158.1.197;
RA Du H., Chalfie M.;
RT "Genes regulating touch cell development in Caenorhabditis elegans.";
RL Genetics 158:197-207(2001).
RN [2]
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Bristol N2;
RX PubMed=9851916; DOI=10.1126/science.282.5396.2012;
RG The C. elegans sequencing consortium;
RT "Genome sequence of the nematode C. elegans: a platform for investigating
RT biology.";
RL Science 282:2012-2018(1998).
RN [3]
RP FUNCTION, AND DEVELOPMENTAL STAGE.
RX PubMed=28716930; DOI=10.1073/pnas.1704194114;
RA Li Y., Zhao D., Horie T., Chen G., Bao H., Chen S., Liu W., Horie R.,
RA Liang T., Dong B., Feng Q., Tao Q., Liu X.;
RT "Conserved gene regulatory module specifies lateral neural borders across
RT bilaterians.";
RL Proc. Natl. Acad. Sci. U.S.A. 114:6352-6360(2017).
CC -!- FUNCTION: Probable transcription factor needed for the proper
CC production of touch cell precursors (PubMed:11333230). Involved in
CC specification of lateral neuroblasts (PubMed:28716930). Essential for
CC embryonic morphogenesis (PubMed:11333230).
CC {ECO:0000269|PubMed:11333230, ECO:0000269|PubMed:28716930}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000255|PROSITE-ProRule:PRU00108,
CC ECO:0000269|PubMed:11333230}.
CC -!- TISSUE SPECIFICITY: Expressed in the ectodermal cells of embryos and
CC seam cells and ventral cord motor neurons of young larvae.
CC {ECO:0000269|PubMed:11333230}.
CC -!- DEVELOPMENTAL STAGE: Expressed from the twofold embryo stage through to
CC L4 larval stage (PubMed:11333230). Expressed in the embryonic mother
CC cell of Q and V5 neuroblasts, AB.p(lr)apapaa, and abolished in V5
CC neuroblasts after division but maintained in Q cells until they divide
CC (PubMed:28716930). Expressed in P-neuroblasts before hatching,
CC maintained while P nuclei migrate into the ventral midline in early L1-
CC stage larvae, and declines after P-neuroblasts divide
CC (PubMed:28716930). {ECO:0000269|PubMed:11333230,
CC ECO:0000269|PubMed:28716930}.
CC -!- DISRUPTION PHENOTYPE: Worms exhibit the absence of AVM, PVM, and PLM
CC touch cells, defective egg laying, embryonic or larval lethality, cell
CC degeneration, malformation of the posterior body, and uncoordinated
CC movement. {ECO:0000269|PubMed:11333230}.
CC -!- SIMILARITY: Belongs to the Msh homeobox family. {ECO:0000305}.
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DR EMBL; AF286218; AAF88063.1; -; mRNA.
DR EMBL; Z48621; CAA88539.1; -; Genomic_DNA.
DR PIR; T23992; T23992.
DR RefSeq; NP_509648.1; NM_077247.5.
DR AlphaFoldDB; Q09604; -.
DR SMR; Q09604; -.
DR BioGRID; 46112; 2.
DR IntAct; Q09604; 2.
DR STRING; 6239.R07B1.1; -.
DR PaxDb; Q09604; -.
DR EnsemblMetazoa; R07B1.1.1; R07B1.1.1; WBGene00006881.
DR GeneID; 181197; -.
DR KEGG; cel:CELE_R07B1.1; -.
DR UCSC; R07B1.1; c. elegans.
DR CTD; 181197; -.
DR WormBase; R07B1.1; CE01626; WBGene00006881; vab-15.
DR eggNOG; KOG0492; Eukaryota.
DR GeneTree; ENSGT00940000169520; -.
DR HOGENOM; CLU_072675_2_0_1; -.
DR InParanoid; Q09604; -.
DR OMA; DPVMIYF; -.
DR OrthoDB; 1400760at2759; -.
DR PhylomeDB; Q09604; -.
DR PRO; PR:Q09604; -.
DR Proteomes; UP000001940; Chromosome X.
DR Bgee; WBGene00006881; Expressed in embryo and 3 other tissues.
DR GO; GO:0005634; C:nucleus; IDA:UniProtKB.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; TAS:UniProtKB.
DR GO; GO:0000981; F:DNA-binding transcription factor activity, RNA polymerase II-specific; IBA:GO_Central.
DR GO; GO:0000977; F:RNA polymerase II transcription regulatory region sequence-specific DNA binding; IBA:GO_Central.
DR GO; GO:0043565; F:sequence-specific DNA binding; TAS:UniProtKB.
DR GO; GO:0048598; P:embryonic morphogenesis; IMP:UniProtKB.
DR GO; GO:0007626; P:locomotory behavior; IMP:UniProtKB.
DR GO; GO:0007567; P:parturition; IMP:UniProtKB.
DR GO; GO:0006357; P:regulation of transcription by RNA polymerase II; IBA:GO_Central.
DR CDD; cd00086; homeodomain; 1.
DR InterPro; IPR009057; Homeobox-like_sf.
DR InterPro; IPR017970; Homeobox_CS.
DR InterPro; IPR001356; Homeobox_dom.
DR InterPro; IPR020479; Homeobox_metazoa.
DR Pfam; PF00046; Homeodomain; 1.
DR PRINTS; PR00024; HOMEOBOX.
DR SMART; SM00389; HOX; 1.
DR SUPFAM; SSF46689; SSF46689; 1.
DR PROSITE; PS00027; HOMEOBOX_1; 1.
DR PROSITE; PS50071; HOMEOBOX_2; 1.
PE 2: Evidence at transcript level;
KW Developmental protein; DNA-binding; Homeobox; Nucleus; Reference proteome;
KW Transcription; Transcription regulation.
FT CHAIN 1..225
FT /note="Homeobox protein vab-15"
FT /id="PRO_0000049350"
FT DNA_BIND 129..188
FT /note="Homeobox"
FT /evidence="ECO:0000255|PROSITE-ProRule:PRU00108"
FT REGION 1..44
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 225 AA; 25228 MW; E7C920E9E1B9AC93 CRC64;
MVSKDEKPKQ SGLFSVESLL ETPKQKCRED LPKPTPITPK TPMLIPGLHP MTPYFGAQLD
PVMIYFAQTG NRLPIVSSDS SPESCASSPL SMQHSLQWLS SQREDSPTSD DAKIQIGLSK
CMLRKHKNNR KPRTPFSTQQ LISLERKFQS KQYLSIAERA EFSASLQLTE TQVKIWFQNR
RAKSKRLQEA EVEKVKFAQA SAYAAAAVGG APDPSSILAF YQPQW
