ID   VAB2_ASHGO              Reviewed;         325 AA.
AC   Q75AC2;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   05-JUL-2004, sequence version 1.
DT   25-MAY-2022, entry version 78.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit VAB2;
DE            Short=BLOC-1 subunit VAB2;
GN   Name=VAB2; OrderedLocusNames=ADL005C;
OS   Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)
OS   (Yeast) (Eremothecium gossypii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Eremothecium.
OX   NCBI_TaxID=284811;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=15001715; DOI=10.1126/science.1095781;
RA   Dietrich F.S., Voegeli S., Brachat S., Lerch A., Gates K., Steiner S.,
RA   Mohr C., Poehlmann R., Luedi P., Choi S., Wing R.A., Flavier A.,
RA   Gaffney T.D., Philippsen P.;
RT   "The Ashbya gossypii genome as a tool for mapping the ancient Saccharomyces
RT   cerevisiae genome.";
RL   Science 304:304-307(2004).
RN   [2]
RP   GENOME REANNOTATION.
RC   STRAIN=ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056;
RX   PubMed=23749448; DOI=10.1534/g3.112.002881;
RA   Dietrich F.S., Voegeli S., Kuo S., Philippsen P.;
RT   "Genomes of Ashbya fungi isolated from insects reveal four mating-type
RT   loci, numerous translocations, lack of transposons, and distinct gene
RT   duplications.";
RL   G3 (Bethesda) 3:1225-1239(2013).
CC   -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1) involved in endosomal cargo sorting. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1
CC       and VAB2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250}. Vacuole
CC       {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VAB2 family. {ECO:0000305}.
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DR   EMBL; AE016817; AAS51916.1; -; Genomic_DNA.
DR   RefSeq; NP_984092.1; NM_209445.1.
DR   AlphaFoldDB; Q75AC2; -.
DR   SMR; Q75AC2; -.
DR   STRING; 33169.AAS51916; -.
DR   EnsemblFungi; AAS51916; AAS51916; AGOS_ADL005C.
DR   GeneID; 4620240; -.
DR   KEGG; ago:AGOS_ADL005C; -.
DR   eggNOG; ENOG502S95F; Eukaryota.
DR   HOGENOM; CLU_855219_0_0_1; -.
DR   InParanoid; Q75AC2; -.
DR   OMA; AHESIEP; -.
DR   Proteomes; UP000000591; Chromosome IV.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005773; C:vacuole; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoplasmic vesicle; Reference proteome; Transport;
KW   Vacuole.
FT   CHAIN           1..325
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit VAB2"
FT                   /id="PRO_0000320511"
FT   COILED          70..135
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   325 AA;  36420 MW;  E752032C965C5389 CRC64;
     MSFLFSGELR SPKNASTERF VSVRGSDAYK ELCSLGMLPS SKDLRQDSIF RAVANEVKQV
     KQDVVEINSR VVAEVQVEKE LAEHLNQKLK ASEYKVDHLA KKLVRLRQKH STNTQRQVRK
     LDDCIGDFES NIRELHGTVA EMVDRLGSVD MGLPEKERLI GDHQLNARHY PLLYELFRDK
     FPSKFGAPRG LGIASSLPER AFPKALGESD TGDLSHHDVA TREAPPLEMD SAEEGCFYHP
     QNLAVDHIRN HFMNSRSSDI NERELEISGS AHATKASSAR ENIPERILMP QFQKVASPQT
     APTLENIEVT VPFSSKSAGH ERHSG