ID   VAB2_KLULA              Reviewed;         281 AA.
AC   Q6CQV5;
DT   26-FEB-2008, integrated into UniProtKB/Swiss-Prot.
DT   16-AUG-2004, sequence version 1.
DT   25-MAY-2022, entry version 70.
DE   RecName: Full=Biogenesis of lysosome-related organelles complex 1 subunit VAB2;
DE            Short=BLOC-1 subunit VAB2;
GN   Name=VAB2; OrderedLocusNames=KLLA0D13948g;
OS   Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 /
OS   NRRL Y-1140 / WM37) (Yeast) (Candida sphaerica).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Saccharomycetaceae; Kluyveromyces.
OX   NCBI_TaxID=284590;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37;
RX   PubMed=15229592; DOI=10.1038/nature02579;
RA   Dujon B., Sherman D., Fischer G., Durrens P., Casaregola S., Lafontaine I.,
RA   de Montigny J., Marck C., Neuveglise C., Talla E., Goffard N., Frangeul L.,
RA   Aigle M., Anthouard V., Babour A., Barbe V., Barnay S., Blanchin S.,
RA   Beckerich J.-M., Beyne E., Bleykasten C., Boisrame A., Boyer J.,
RA   Cattolico L., Confanioleri F., de Daruvar A., Despons L., Fabre E.,
RA   Fairhead C., Ferry-Dumazet H., Groppi A., Hantraye F., Hennequin C.,
RA   Jauniaux N., Joyet P., Kachouri R., Kerrest A., Koszul R., Lemaire M.,
RA   Lesur I., Ma L., Muller H., Nicaud J.-M., Nikolski M., Oztas S.,
RA   Ozier-Kalogeropoulos O., Pellenz S., Potier S., Richard G.-F.,
RA   Straub M.-L., Suleau A., Swennen D., Tekaia F., Wesolowski-Louvel M.,
RA   Westhof E., Wirth B., Zeniou-Meyer M., Zivanovic Y., Bolotin-Fukuhara M.,
RA   Thierry A., Bouchier C., Caudron B., Scarpelli C., Gaillardin C.,
RA   Weissenbach J., Wincker P., Souciet J.-L.;
RT   "Genome evolution in yeasts.";
RL   Nature 430:35-44(2004).
CC   -!- FUNCTION: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1) involved in endosomal cargo sorting. {ECO:0000250}.
CC   -!- SUBUNIT: Component of the biogenesis of lysosome-related organelles
CC       complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1
CC       and VAB2. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cytoplasmic vesicle {ECO:0000250}. Vacuole
CC       {ECO:0000250}. Cytoplasm {ECO:0000250}.
CC   -!- SIMILARITY: Belongs to the VAB2 family. {ECO:0000305}.
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DR   EMBL; CR382124; CAH00780.1; -; Genomic_DNA.
DR   RefSeq; XP_453684.1; XM_453684.1.
DR   AlphaFoldDB; Q6CQV5; -.
DR   SMR; Q6CQV5; -.
DR   EnsemblFungi; CAH00780; CAH00780; KLLA0_D13948g.
DR   GeneID; 2892968; -.
DR   KEGG; kla:KLLA0_D13948g; -.
DR   HOGENOM; CLU_990667_0_0_1; -.
DR   InParanoid; Q6CQV5; -.
DR   OMA; HICITEP; -.
DR   Proteomes; UP000000598; Chromosome D.
DR   GO; GO:0031410; C:cytoplasmic vesicle; IEA:UniProtKB-KW.
DR   GO; GO:0005773; C:vacuole; IEA:UniProtKB-SubCell.
PE   3: Inferred from homology;
KW   Coiled coil; Cytoplasm; Cytoplasmic vesicle; Reference proteome; Transport;
KW   Vacuole.
FT   CHAIN           1..281
FT                   /note="Biogenesis of lysosome-related organelles complex 1
FT                   subunit VAB2"
FT                   /id="PRO_0000320513"
FT   REGION          170..235
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COILED          67..92
FT                   /evidence="ECO:0000255"
SQ   SEQUENCE   281 AA;  31788 MW;  1421DBE93B0E8A31 CRC64;
     MSFLFYGDSK HLRKRESFHF ATIEKSDYSK QLQSLPLLPS SSSLRQDHIF SNVAKEVNQI
     SDDVAIIYSR LQEEIDTEQS QTKEVNNKIN HSVKKLESSF SKLVKLRSKF TKDSDKQLKQ
     FESKYSDIDK KVRIIRDVNE ELLDYVTRNG SIKVDATQFS KISKLLQERF PESSNTTETE
     ANKDNSGQSQ NEANSESLNS SYSRQSTNGS QNNAKKDYHS TKGNSADSNT TKSYRQSISS
     APLALSSIRS TSRPSIATTL EHICITEPFT RPRGMSKSAD L